RT Journal Article SR Electronic(1) A1 Sherwood, Victoria A1 King, Elizabeth A1 Tötemeyer, Sabine A1 Connerton, Ian A1 Mellits, Kenneth H.YR 2012 T1 Interferon treatment suppresses enteric adenovirus infection in a model gastrointestinal cell-culture system JF Journal of General Virology, VO 93 IS 3 SP 618 OP 623 DO https://doi.org/10.1099/vir.0.037556-0 PB Microbiology Society, SN 1465-2099, AB Exposure to interferon results in the rapid transcriptional induction of genes, many of which function to create an antiviral environment in potential host cells. For the majority of adenoviruses, replication is unaffected by the actions of interferon. It has previously been shown, using non-gastrointestinal cells, that the species F human adenoviruses are sensitive to the action of interferon. Here, we have developed an enterocyte-like cell-culture model to re-evaluate this question, and determined the effects of interferon on species F adenovirus during infection of gastrointestinal cells. We show that species F adenovirus type 40 is sensitive to the effects of interferon in gastrointestinal-like cells, which may help to explain its fastidious growth in culture., UL https://www.microbiologyresearch.org/content/journal/jgv/10.1099/vir.0.037556-0