1887

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Volume 93, Issue 3

Canine ASCT1 and ASCT2 are functional receptors for RD-114 virus in dogs Free

Abstract

All domestic cats carry an infectious endogenous retrovirus termed RD-114 virus. Recently, we and others found that several live-attenuated vaccines for dogs were contaminated with infectious RD-114 virus. In this study, we confirmed that the RD-114 virus efficiently infected and proliferated well in canine primary kidney cells, as well as three tested canine cell lines. Further, we identified canine ASCT1 and ASCT2, sodium-dependent neutral amino acid transporters, as RD-114 virus receptors. Canine ASCT2 also acts as a functional receptor for simian retrovirus 2, a pathogenic retrovirus that induces immunodeficiency in rhesus macaques. Identification of the canine receptor for RD-114 virus will help in evaluating the risk from vaccines contaminated by the virus.

  • Received:
  • Accepted:
  • Published Online:
© 2012 SGM
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2012-03-01
2024-04-25
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Canine ASCT1 and ASCT2 are functional receptors for RD-114 virus in dogs
J. Gen. Virol. 93, 603 (2012); https://doi.org/10.1099/vir.0.036228-0
/content/journal/jgv/10.1099/vir.0.036228-0
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