1887

Abstract

All domestic cats carry an infectious endogenous retrovirus termed RD-114 virus. Recently, we and others found that several live-attenuated vaccines for dogs were contaminated with infectious RD-114 virus. In this study, we confirmed that the RD-114 virus efficiently infected and proliferated well in canine primary kidney cells, as well as three tested canine cell lines. Further, we identified canine ASCT1 and ASCT2, sodium-dependent neutral amino acid transporters, as RD-114 virus receptors. Canine ASCT2 also acts as a functional receptor for simian retrovirus 2, a pathogenic retrovirus that induces immunodeficiency in rhesus macaques. Identification of the canine receptor for RD-114 virus will help in evaluating the risk from vaccines contaminated by the virus.

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2012-03-01
2021-10-17
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References

  1. Arriza J. L., Kavanaugh M. P., Fairman W. A., Wu Y. N., Murdoch G. H., North R. A., Amara S. G. 1993; Cloning and expression of a human neutral amino acid transporter with structural similarity to the glutamate transporter gene family. J Biol Chem 268:15329–15332[PubMed]
    [Google Scholar]
  2. Baumann J. G., Günzburg W. H., Salmons B. 1998; CrFK feline kidney cells produce an RD114-like endogenous virus that can package murine leukemia virus-based vectors. J Virol 72:7685–7687[PubMed]
    [Google Scholar]
  3. Blaise S., Mangeney M., Heidmann T. 2001; The envelope of Mason–Pfizer monkey virus has immunosuppressive properties. J Gen Virol 82:1597–1600[PubMed]
    [Google Scholar]
  4. Cianciolo G. J., Copeland T. D., Oroszlan S., Snyderman R. 1985; Inhibition of lymphocyte proliferation by a synthetic peptide homologous to retroviral envelope proteins. Science 230:453–455 [View Article][PubMed]
    [Google Scholar]
  5. Cosset F. L., Takeuchi Y., Battini J. L., Weiss R. A., Collins M. K. 1995; High-titer packaging cells producing recombinant retroviruses resistant to human serum. J Virol 69:7430–7436[PubMed]
    [Google Scholar]
  6. Fischinger P. J., Peebles P. T., Nomura S., Haapala D. K. 1973; Isolation of RD-114-like oncornavirus from a cat cell line. J Virol 11:978–985[PubMed]
    [Google Scholar]
  7. Green B. J., Lee C. S., Rasko J. E. J. 2004; Biodistribution of the RD114/mammalian type D retrovirus receptor, RDR. J Gene Med 6:249–259 [View Article][PubMed]
    [Google Scholar]
  8. Marin M., Tailor C. S., Nouri A., Kabat D. 2000; Sodium-dependent neutral amino acid transporter type 1 is an auxiliary receptor for baboon endogenous retrovirus. J Virol 74:8085–8093 [View Article][PubMed]
    [Google Scholar]
  9. Marin M., Lavillette D., Kelly S. M., Kabat D. 2003; N-Linked glycosylation and sequence changes in a critical negative control region of the ASCT1 and ASCT2 neutral amino acid transporters determine their retroviral receptor functions. J Virol 77:2936–2945 [View Article][PubMed]
    [Google Scholar]
  10. Marx P. A., Maul D. H., Osborn K. G., Lerche N. W., Moody P., Lowenstine L. J., Henrickson R. V., Arthur L. O., Gilden R. V. other authors 1984; Simian AIDS: isolation of a type D retrovirus and transmission of the disease. Science 223:1083–1086 [View Article][PubMed]
    [Google Scholar]
  11. Marx P. A., Bryant M. L., Osborn K. G., Maul D. H., Lerche N. W., Lowenstine L. J., Kluge J. D., Zaiss C. P., Henrickson R. V. other authors 1985; Isolation of a new serotype of simian acquired immune deficiency syndrome type D retrovirus from Celebes black macaques (Macaca nigra) with immune deficiency and retroperitoneal fibromatosis. J Virol 56:571–578[PubMed]
    [Google Scholar]
  12. Miyazawa T., Yoshikawa R., Golder M., Okada M., Stewart H., Palmarini M. 2010; Isolation of an infectious endogenous retrovirus in a proportion of live attenuated vaccines for pets. J Virol 84:3690–3694 [View Article][PubMed]
    [Google Scholar]
  13. Montiel N. A. 2010; An updated review of simian betaretrovirus (SRV) in macaque hosts. J Med Primatol 39:303–314 [View Article][PubMed]
    [Google Scholar]
  14. Narushima R., Usui T., Ogawa T., Shimazaki T. 2010; Detection of infectious RD114 virus in feline live multivalent vaccines and provisional safety evaluation in cats. J Jpn Vet Med Assoc 63:630–633 (in Japanese with English summary)
    [Google Scholar]
  15. Narushima R., Horiuchi N., Usui T., Ogawa T., Takahashi T., Shimazaki T. 2011a; Experimental infection of dogs with a feline endogenous retrovirus RD-114. Acta Vet Scand 53:3 [View Article][PubMed]
    [Google Scholar]
  16. Narushima R., Shimazaki T., Takahashi T. 2011b; Development of a real-time reverse-transcription-PCR method for detection of RD114 virus in canine vaccines. Biologicals 39:89–93 [View Article][PubMed]
    [Google Scholar]
  17. Okabe H., Gilden R. V., Hatanaka M. 1973; RD 114 virus-specific sequences in feline cellular RNA: detection and characterization. J Virol 12:984–994[PubMed]
    [Google Scholar]
  18. Okada M., Yoshikawa R., Shojima T., Baba K., Miyazawa T. 2011; Susceptibility and production of a feline endogenous retrovirus (RD-114 virus) in various feline cell lines. Virus Res 155:268–273 [View Article][PubMed]
    [Google Scholar]
  19. Rasko J. E., Battini J. L., Gottschalk R. J., Mazo I., Miller A. D. 1999; The RD114/simian type D retrovirus receptor is a neutral amino acid transporter. Proc Natl Acad Sci U S A 96:2129–2134 [View Article][PubMed]
    [Google Scholar]
  20. Roth M. G., Srinivas R. V., Compans R. W. 1983; Basolateral maturation of retroviruses in polarized epithelial cells. J Virol 45:1065–1073[PubMed]
    [Google Scholar]
  21. Sakaguchi S., Baba K., Ishikawa M., Yoshikawa R., Shojima T., Miyazawa T. 2008a; Focus assay on RD114 virus in QN10S cells. J Vet Med Sci 70:1383–1386 [View Article][PubMed]
    [Google Scholar]
  22. Sakaguchi S., Okada M., Shojima T., Baba K., Miyazawa T. 2008b; Establishment of a LacZ marker rescue assay to detect infectious RD114 virus. J Vet Med Sci 70:785–790 [View Article][PubMed]
    [Google Scholar]
  23. Stratton M. R., Darling J., Pilkington G. J., Lantos P. L., Reeves B. R., Cooper C. S. 1989; Characterization of the human cell line TE671. Carcinogenesis 10:899–905[PubMed] [CrossRef]
    [Google Scholar]
  24. Tailor C. S., Nouri A., Zhao Y., Takeuchi Y., Kabat D. 1999; A sodium-dependent neutral-amino-acid transporter mediates infections of feline and baboon endogenous retroviruses and simian type D retroviruses. J Virol 73:4470–4474[PubMed]
    [Google Scholar]
  25. Takeuchi Y., Simpson G., Vile R. G., Weiss R. A., Collins M. K. 1992; Retroviral pseudotypes produced by rescue of a Moloney murine leukemia virus vector by C-type, but not D-type, retroviruses. Virology 186:792–794 [View Article][PubMed]
    [Google Scholar]
  26. Takeuchi Y., Cosset F.-L. C., Lachmann P. J., Okada H., Weiss R. A., Collins M. K. L. 1994; Type C retrovirus inactivation by human complement is determined by both the viral genome and the producer cell. J Virol 68:8001–8007[PubMed]
    [Google Scholar]
  27. Takeuchi Y., Porter C. D., Strahan K. M., Preece A. F., Gustafsson K., Cosset F.-L., Weiss R. A., Collins M. K. L. 1996; Sensitization of cells and retroviruses to human serum by (α1-3) galactosyltransferase. Nature 379:85–88 [View Article][PubMed]
    [Google Scholar]
  28. Ting-De Ravin S. S., Kennedy D. R., Naumann N., Kennedy J. S., Choi U., Hartnett B. J., Linton G. F., Whiting-Theobald N. L., Moore P. F. other authors 2006; Correction of canine X-linked severe combined immunodeficiency by in vivo retroviral gene therapy. Blood 107:3091–3097 [View Article][PubMed]
    [Google Scholar]
  29. Utsunomiya-Tate N., Endou H., Kanai Y. 1996; Cloning and functional characterization of a system ASC-like Na+-dependent neutral amino acid transporter. J Biol Chem 271:14883–14890 [View Article][PubMed]
    [Google Scholar]
  30. Yoshikawa R., Sato E., Igarashi T., Miyazawa T. 2010; Characterization of RD-114 virus isolated from a commercial canine vaccine manufactured using CRFK cells. J Clin Microbiol 48:3366–3369 [View Article][PubMed]
    [Google Scholar]
  31. Yoshikawa R., Sato E., Miyazawa T. 2011a; Contamination of infectious RD-114 virus in vaccines produced using non-feline cell lines. Biologicals 39:33–37 [View Article][PubMed]
    [Google Scholar]
  32. Yoshikawa R., Sato E., Miyazawa T. 2011b; Presence of infectious RD-114 virus in a proportion of canine parvovirus isolates. J Vet Med Sci in press http://dx.doi.org/10.1292/jvms.11-0219 [View Article][PubMed]
    [Google Scholar]
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