1887

Abstract

Influenza A and B viruses are major human respiratory pathogens that contribute to the burden of seasonal influenza. They are both members of the family but do not interact genetically and are classified in different genera. Defective interfering (DI) influenza viruses have a major deletion of one or more of their eight genome segments, which renders them both non-infectious and able to interfere in cell culture with the production of infectious progeny by a genetically compatible, homologous virus. It has been shown previously that intranasal administration of a cloned DI influenza A virus, 244/PR8, protects mice from various homologous influenza A virus subtypes and that it also protects mice from respiratory disease caused by a heterologous virus belonging to the family . The mechanisms of action differ, with homologous and heterologous protection being mediated by probable genome competition and type I interferon (IFN), respectively. In the current study, it was shown that 244/PR8 also protects against disease caused by a heterologous influenza B virus (B/Lee/40). Protection from B/Lee/40 challenge was partially eliminated in mice that did not express a functional type I IFN receptor, suggesting that innate immunity, and type I IFN in particular, are important in mediating protection against this virus. It was concluded that 244/PR8 has the ability to protect against heterologous IFN-sensitive respiratory viruses, in addition to homologous influenza A viruses, and that it acts by fundamentally different mechanisms.

Loading

Article metrics loading...

/content/journal/jgv/10.1099/vir.0.034132-0
2011-09-01
2019-10-17
Loading full text...

Full text loading...

/deliver/fulltext/jgv/92/9/2122.html?itemId=/content/journal/jgv/10.1099/vir.0.034132-0&mimeType=html&fmt=ahah

References

  1. Barrett A. D. T. , Dimmock N. J. . ( 1984; ). Modulation of Semliki Forest virus-induced infection of mice by defective-interfering virus. . J Infect Dis 150:, 98–104. [CrossRef].[PubMed]
    [Google Scholar]
  2. Barrett A. D. T. , Dimmock N. J. . ( 1986; ). Defective interfering viruses and infections of animals. . Curr Top Microbiol Immunol 128:, 55–84.[PubMed]
    [Google Scholar]
  3. Barrett A. D. T. , Guest A. R. , Mackenzie A. , Dimmock N. J. . ( 1984; ). Protection of mice infected with a lethal dose of Semliki Forest virus by defective interfering virus: modulation of virus multiplication. . J Gen Virol 65:, 1909–1920. [CrossRef].[PubMed]
    [Google Scholar]
  4. Baum A. , Sachidanandam R. , García-Sastre A. . ( 2010; ). Preference of RIG-I for short viral RNA molecules in infected cells revealed by next-generation sequencing. . Proc Natl Acad Sci U S A 107:, 16303–16308. [CrossRef].[PubMed]
    [Google Scholar]
  5. Dimmock N. J. . ( 1991; ). The biological significance of defective interfering viruses. . Rev Med Virol 1:, 165–176. [CrossRef]
    [Google Scholar]
  6. Dimmock N. J. . ( 1996; ). Antiviral activity of defective interfering influenza virus in vivo . . In Viral and Other Infections of the Respiratory Tract, pp. 421–445. Edited by Myint S. , Taylor-Robinson D. . . London:: Chapman & Hall;.
    [Google Scholar]
  7. Dimmock N. J. , Marriott A. C. . ( 2006; ). In vivo antiviral activity: defective interfering virus protects better against virulent Influenza A virus than avirulent virus. . J Gen Virol 87:, 1259–1265. [CrossRef].[PubMed]
    [Google Scholar]
  8. Dimmock N. J. , Beck S. , McLain L. . ( 1986; ). Protection of mice from lethal influenza: evidence that defective interfering virus modulates the immune response and not virus multiplication. . J Gen Virol 67:, 839–850. [CrossRef].[PubMed]
    [Google Scholar]
  9. Dimmock N. J. , Rainsford E. W. , Scott P. D. , Marriott A. C. . ( 2008; ). Influenza virus protecting RNA: an effective prophylactic and therapeutic antiviral. . J Virol 82:, 8570–8578. [CrossRef].[PubMed]
    [Google Scholar]
  10. Duhaut S. D. , Dimmock N. J. . ( 1998; ). Heterologous protection of mice from a lethal human H1N1 influenza A virus infection by H3N8 equine defective interfering virus: comparison of defective RNA sequences isolated from the DI inoculum and mouse lung. . Virology 248:, 241–253. [CrossRef].[PubMed]
    [Google Scholar]
  11. Duhaut S. , Dimmock N. J. . ( 2000; ). Approximately 150 nucleotides from the 5′ end of an influenza A segment 1 defective virion RNA are needed for genome stability during passage of defective virus in infected cells. . Virology 275:, 278–285. [CrossRef].[PubMed]
    [Google Scholar]
  12. Duhaut S. D. , Dimmock N. J. . ( 2002; ). Defective segment 1 RNAs that interfere with production of infectious influenza A virus require at least 150 nucleotides of 5′ sequence: evidence from a plasmid-driven system. . J Gen Virol 83:, 403–411.[PubMed]
    [Google Scholar]
  13. Duhaut S. D. , Dimmock N. J. . ( 2003; ). Defective influenza A virus generated entirely from plasmids: its RNA is expressed in infected mouse lung and modulates disease. . J Virol Methods 108:, 75–82. [CrossRef].[PubMed]
    [Google Scholar]
  14. Easton A. J. , Scott P. D. , Edworthy N. L. , Meng B. , Marriott A. C. , Dimmock N. J. . ( 2011; ). A novel broad-spectrum treatment for respiratory virus infections: influenza-based defective interfering virus provides protection against pneumovirus infection in vivo . . Vaccine 29:, 2777–2784. [CrossRef].[PubMed]
    [Google Scholar]
  15. Frey T. K. , Jones E. V. , Cardamone J. J. Jr , Youngner J. S. . ( 1979; ). Induction of interferon in L cells by defective-interfering (DI) particles of vesicular stomatitis virus: lack of correlation with content of [±] snapback RNA. . Virology 99:, 95–102.[CrossRef]
    [Google Scholar]
  16. Gidlund M. , Örn A. , Wigzell H. , Senik A. , Gresser I. . ( 1978; ). Enhanced NK cell activity in mice injected with interferon and interferon inducers. . Nature 273:, 759–761. [CrossRef].[PubMed]
    [Google Scholar]
  17. Holland J. J. . ( 1990a; ). Defective viral genomes. . In Virology, , 2nd edn., pp. 151–165. Edited by Fields B. N. , Knipe D. M. . . New York:: Raven Press;.
    [Google Scholar]
  18. Holland J. J. . ( 1990b; ). Generation and replication of defective viral genomes. . In Virology, , 2nd edn., pp. 77–99. Edited by Fields B. N. , Knipe D. M. . . New York:: Raven Press;.
    [Google Scholar]
  19. Horimoto T. , Takada A. , Iwatsuki-Horimoto K. , Hatta M. , Goto H. , Kawaoka Y. . ( 2003; ). Generation of influenza A viruses with chimeric (type A/B) hemagglutinins. . J Virol 77:, 8031–8038. [CrossRef].[PubMed]
    [Google Scholar]
  20. Huang A. S. , Baltimore D. . ( 1970; ). Defective viral particles and viral disease processes. . Nature 226:, 325–327. [CrossRef].[PubMed]
    [Google Scholar]
  21. Jackson D. , Cadman A. , Zurcher T. , Barclay W. S. . ( 2002; ). A reverse genetics approach for recovery of recombinant influenza B viruses entirely from cDNA. . J Virol 76:, 11744–11747. [CrossRef].[PubMed]
    [Google Scholar]
  22. Jewell N. A. , Cline T. , Mertz S. E. , Smirnov S. V. , Flaño E. , Schindler C. , Grieves J. L. , Durbin R. K. , Kotenko S. V. , Durbin J. E. . ( 2010; ). Lambda interferon is the predominant interferon induced by influenza A virus infection in vivo . . J Virol 84:, 11515–11522. [CrossRef].[PubMed]
    [Google Scholar]
  23. Kaverin N. V. , Varich N. L. , Sklyanskaya E. I. , Amvrosieva T. V. , Petrik J. , Vovk T. C. . ( 1983; ). Studies on heterotypic interference between influenza A and B viruses: a differential inhibition of the synthesis of viral proteins and RNAs. . J Gen Virol 64:, 2139–2146. [CrossRef].[PubMed]
    [Google Scholar]
  24. Marcus P. I. , Gaccione C. . ( 1989; ). Interferon induction by viruses. XIX. Vesicular stomatitis virus–New Jersey: high multiplicity passages generate interferon-inducing, defective-interfering particles. . Virology 171:, 630–633. [CrossRef].[PubMed]
    [Google Scholar]
  25. Marcus P. I. , Sekellick M. J. . ( 1977; ). Defective interfering particles with covalently linked [±]RNA induce interferon. . Nature 266:, 815–819. [CrossRef].[PubMed]
    [Google Scholar]
  26. Mikheeva A. V. , Ghendon Y. Z. . ( 1982; ). Intrinsic interference between influenza A and B viruses. . Arch Virol 73:, 287–294. [CrossRef].[PubMed]
    [Google Scholar]
  27. Mordstein M. , Kochs G. , Dumoutier L. , Renauld J. C. , Paludan S. R. , Klucher K. , Staeheli P. . ( 2008; ). Interferon-λ contributes to innate immunity of mice against influenza A virus but not against hepatotropic viruses. . PLoS Pathog 4:, e1000151. [CrossRef].[PubMed]
    [Google Scholar]
  28. Mordstein M. , Neugebauer E. , Ditt V. , Jessen B. , Rieger T. , Falcone V. , Sorgeloos F. , Ehl S. , Mayer D. et al. ( 2010; ). Lambda interferon renders epithelial cells of the respiratory and gastrointestinal tracts resistant to viral infections. . J Virol 84:, 5670–5677. [CrossRef].[PubMed]
    [Google Scholar]
  29. Morgan D. J. , Dimmock N. J. . ( 1992; ). Defective interfering influenza virus inhibits immunopathological effects of infectious virus in the mouse. . J Virol 66:, 1188–1192.[PubMed]
    [Google Scholar]
  30. Nayak D. P. . ( 1980; ). Defective interfering influenza viruses. . Annu Rev Microbiol 34:, 619–644. [CrossRef].[PubMed]
    [Google Scholar]
  31. Nayak D. P. , Chambers T. M. , Akkina R. K. . ( 1985; ). Defective-interfering (DI) RNAs of influenza viruses: origin, structure, expression, and interference. . Curr Top Microbiol Immunol 114:, 103–151.[PubMed]
    [Google Scholar]
  32. Nayak D. P. , Chambers T. M. , Akkina R. M. . ( 1989; ). Structure of defective-interfering RNAs of influenza virus and their role in interference. . In The Influenza Viruses, pp. 269–317. Edited by Krug R. M. . . New York:: Plenum Press;.
    [Google Scholar]
  33. Noble S. , Dimmock N. J. . ( 1994; ). Defective interfering type A equine influenza virus (H3N8) protects mice from morbidity and mortality caused by homologous and heterologous subtypes of influenza A virus. . J Gen Virol 75:, 3485–3491. [CrossRef].[PubMed]
    [Google Scholar]
  34. Noble S. , McLain L. , Dimmock N. J. . ( 2004; ). Interfering vaccine: a novel antiviral that converts a potentially virulent infection into one that is subclinical and immunizing. . Vaccine 22:, 3018–3025. [CrossRef].[PubMed]
    [Google Scholar]
  35. Perrault J. . ( 1981; ). Origin and replication of defective interfering particles. . Curr Top Microbiol Immunol 93:, 151–207.[PubMed]
    [Google Scholar]
  36. Roux L. , Simon A. E. , Holland J. J. . ( 1991; ). Effects of defective interfering viruses on virus replication and pathogenesis in vitro and in vivo . . Adv Virus Res 40:, 181–211. [CrossRef].[PubMed]
    [Google Scholar]
  37. Sekellick M. J. , Marcus P. I. . ( 1982; ). Interferon induction by viruses. VIII. Vesicular stomatitis virus: [±]DI-011 particles induce interferon in the absence of standard virions. . Virology 117:, 280–285. [CrossRef].[PubMed]
    [Google Scholar]
  38. Strahle L. , Garcin D. , Kolakofsky D. . ( 2006; ). Sendai virus defective-interfering genomes and the activation of interferon-β. . Virology 351:, 101–111. [CrossRef].[PubMed]
    [Google Scholar]
  39. Tobita K. , Tanaka T. , Goto H. , Feng S.-Y. . ( 1983; ). Temperature-sensitive influenza A virus clones originated by a cross between A/Aichi/2/68 (H3N2) and B/Yamagata/1/73. . Arch Virol 75:, 17–27. [CrossRef].[PubMed]
    [Google Scholar]
  40. Wunderlich K. , Juozapaitis M. , Mänz B. , Mayer D. , Götz V. , Zöhner A. , Wolff T. , Schwemmle M. , Martin A. . ( 2010; ). Limited compatibility of polymerase subunit interactions in influenza A and B viruses. . J Biol Chem 285:, 16704–16712. [CrossRef].[PubMed]
    [Google Scholar]
http://instance.metastore.ingenta.com/content/journal/jgv/10.1099/vir.0.034132-0
Loading
/content/journal/jgv/10.1099/vir.0.034132-0
Loading

Data & Media loading...

Most Cited This Month

This is a required field
Please enter a valid email address
Approval was a Success
Invalid data
An Error Occurred
Approval was partially successful, following selected items could not be processed due to error