1887

Abstract

New insights into the early viral evolution and cellular immune response during acute hepatitis C virus (HCV) infection are being gained following a global outbreak in human immunodeficiency virus-1 (HIV)-positive men who have sex with men. Cross-sectional and longitudinal sequence analysis at both the population and individual level have facilitated tracking of the HCV epidemic across the world and enabled the development of tests of viral diversity in individual patients in order to predict spontaneous clearance of HCV and response to treatment. Immunological studies in HIV-positive cohorts have highlighted the role of the CD4 T-cell response in the control of early HCV infection and will increase the opportunity for the identification of protective epitopes that could be used in future vaccine development.

  • This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
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2011-10-01
2021-10-24
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References

  1. Aberle J. H., Formann E., Steindl-Munda P., Weseslindtner L., Gurguta C., Perstinger G., Grilnberger E., Laferl H., Dienes H. P., Popowkraupp T. 2006; Prospective study of viral clearance and CD4+ T-cell response in acute hepatitis C primary infection and reinfection. J Clin Virol 36:24–31 [View Article][PubMed]
    [Google Scholar]
  2. Arnold D. M., Julian J. A., Walker I. R. Association of Hemophilia Clinic Directors of Canada 2006; Mortality rates and causes of death among all HIV-positive individuals with hemophilia in Canada over 21 years of follow-up. Blood 108:460–464 [View Article][PubMed]
    [Google Scholar]
  3. Bader T., Fazili J., Madhoun M., Aston C., Hughes D., Rizvi S., Seres K., Hasan M. 2008; Fluvastatin inhibits hepatitis C replication in humans. Am J Gastroenterol 103:1383–1389 [View Article][PubMed]
    [Google Scholar]
  4. Bernini F., Ebranati E., De Maddalena C., Shkjezi R., Milazzo L., Lo Presti A., Ciccozzi M., Galli M., Zehender G. 2011; Within-host dynamics of the hepatitis C virus quasispecies population in HIV-1/HCV coinfected patients. PLoS ONE 6:e16551 [View Article][PubMed]
    [Google Scholar]
  5. Bica I., McGovern B., Dhar R., Stone D., McGowan K., Scheib R., Snydman D. R. 2001; Increasing mortality due to end-stage liver disease in patients with human immunodeficiency virus infection. Clin Infect Dis 32:492–497 [View Article][PubMed]
    [Google Scholar]
  6. Blackard J. T., Hiasa Y., Smeaton L., Jamieson D. J., Rodriguez I., Mayer K. H., Chung R. T. 2007; Compartmentalization of hepatitis C virus (HCV) during HCV/HIV coinfection. J Infect Dis 195:1765–1773 [CrossRef]
    [Google Scholar]
  7. Bottieau E., Apers L., Van Esbroeck M., Vandenbruaene M., Florence E. 2010; Hepatitis C virus infection in HIV-infected men who have sex with men: sustained rising incidence in Antwerp, Belgium, 2001–2009. Euro Surveill 15:19673[PubMed]
    [Google Scholar]
  8. Campo D. S., Dimitrova Z., Mitchell R. J., Lara J., Khudyakov Y. 2008; Coordinated evolution of the hepatitis C virus. Proc Natl Acad Sci U S A 105:9685–9690 [View Article][PubMed]
    [Google Scholar]
  9. Capa L., Soriano V., García-Samaniego J., Nuñez M., Romero M., Cascajero A., Muñoz F., González-Lahoz J., Benito J. M. 2007; Influence of HCV genotype and co-infection with human immunodeficiency virus on CD4+ and CD8+ T-cell responses to hepatitis C virus. J Med Virol 79:503–510 [View Article][PubMed]
    [Google Scholar]
  10. Cheent K., Khakoo S. I. 2011; Natural killer cells and hepatitis C: action and reaction. Gut 60:268–278 [View Article][PubMed]
    [Google Scholar]
  11. Cooper S., Erickson A. L., Adams E. J., Kansopon J., Weiner A. J., Chien D. Y., Houghton M., Parham P., Walker C. M. 1999; Analysis of a successful immune response against hepatitis C virus. Immunity 10:439–449 [View Article][PubMed]
    [Google Scholar]
  12. Cox A. L., Mosbruger T., Lauer G. M., Pardoll D., Thomas D. L., Ray S. C. 2005; Comprehensive analyses of CD8+ T cell responses during longitudinal study of acute human hepatitis C. Hepatology 42:104–112 [View Article][PubMed]
    [Google Scholar]
  13. Dahari H., Major M., Zhang X., Mihalik K., Rice C. M., Perelson A. S., Feinstone S. M., Neumann A. U. 2005; Mathematical modeling of primary hepatitis C infection: noncytolytic clearance and early blockage of virion production. Gastroenterology 128:1056–1066 [View Article][PubMed]
    [Google Scholar]
  14. Danta M., Brown D., Bhagani S., Pybus O. G., Sabin C. A., Nelson M., Fisher M., Johnson A. M., Dusheiko G. M. HIV and Acute HCV (HAAC) group 2007; Recent epidemic of acute hepatitis C virus in HIV-positive men who have sex with men linked to high-risk sexual behaviours. AIDS 21:983–991 [View Article][PubMed]
    [Google Scholar]
  15. Danta M., Semmo N., Fabris P., Brown D., Pybus O. G., Sabin C. A., Bhagani S., Emery V. C., Dusheiko G. M., Klenerman P. 2008; Impact of HIV on host-virus interactions during early hepatitis C virus infection. J Infect Dis 197:1558–1566 [View Article][PubMed]
    [Google Scholar]
  16. de Bruijne J., Schinkel J., Prins M., Koekkoek S. M., Aronson S. J., van Ballegooijen M. W., Reesink H. W., Molenkamp R., van de Laar T. J. 2009; Emergence of hepatitis C virus genotype 4: phylogenetic analysis reveals three distinct epidemiological profiles. J Clin Microbiol 47:3832–3838 [View Article][PubMed]
    [Google Scholar]
  17. Dominguez S., Ghosn J., Valantin M. A., Schruniger A., Simon A., Bonnard P., Caumes E., Pialoux G., Benhamou Y. et al. other authors 2006; Efficacy of early treatment of acute hepatitis C infection with pegylated interferon and ribavirin in HIV-infected patients. AIDS 20:1157–1161 [View Article][PubMed]
    [Google Scholar]
  18. Enomoto N., Maekawa S. 2010; HCV genetic elements determining the early response to peginterferon and ribavirin therapy. Intervirology 53:66–69 [View Article][PubMed]
    [Google Scholar]
  19. Enomoto N., Sakuma I., Asahina Y., Kurosaki M., Murakami T., Yamamoto C., Izumi N., Marumo F., Sato C. 1995; Comparison of full-length sequences of interferon-sensitive and resistant hepatitis C virus 1b. Sensitivity to interferon is conferred by amino acid substitutions in the NS5A region. J Clin Invest 96:224–230 [View Article][PubMed]
    [Google Scholar]
  20. Enomoto N., Sakuma I., Asahina Y., Kurosaki M., Murakami T., Yamamoto C., Ogura Y., Izumi N., Marumo F., Sato C. 1996; Mutations in the nonstructural protein 5A gene and response to interferon in patients with chronic hepatitis C virus 1b infection. N Engl J Med 334:77–82 [View Article][PubMed]
    [Google Scholar]
  21. Fanning L. J., Levis J., Kenny-Walsh E., Whelton M., O’Sullivan K., Shanahan F. 2001; HLA class II genes determine the natural variance of hepatitis C viral load. Hepatology 33:224–230 [View Article][PubMed]
    [Google Scholar]
  22. Farci P., Shimoda A., Coiana A., Diaz G., Peddis G., Melpolder J. C., Strazzera A., Chien D. Y., Munoz S. J. et al. other authors 2000; The outcome of acute hepatitis C predicted by the evolution of the viral quasispecies. Science 288:339–344 [View Article][PubMed]
    [Google Scholar]
  23. Felmlee D. J., Sheridan D. A., Bridge S. H., Nielsen S. U., Milne R. W., Packard C. J., Caslake M. J., McLauchlan J., Toms G. L. et al. other authors 2010; Intravascular transfer contributes to postprandial increase in numbers of very-low-density hepatitis C virus particles. Gastroenterology 139:1774–1783.e6 [View Article][PubMed]
    [Google Scholar]
  24. Fernandez J., Taylor D., Morhardt D. R., Mihalik K., Puig M., Rice C. M., Feinstone S. M., Major M. E. 2004; Long-term persistence of infection in chimpanzees inoculated with an infectious hepatitis C virus clone is associated with a decrease in the viral amino acid substitution rate and low levels of heterogeneity. J Virol 78:9782–9789 [View Article][PubMed]
    [Google Scholar]
  25. Fierer D. S., Uriel A. J., Carriero D. C., Klepper A., Dieterich D. T., Mullen M. P., Thung S. N., Fiel M. I., Branch A. D. 2008; Liver fibrosis during an outbreak of acute hepatitis C virus infection in HIV-infected men: a prospective cohort study. J Infect Dis 198:683–686 [View Article][PubMed]
    [Google Scholar]
  26. Forton D. M., Karayiannis P., Mahmud N., Taylor-Robinson S. D., Thomas H. C. 2004; Identification of unique hepatitis C virus quasispecies in the central nervous system and comparative analysis of internal translational efficiency of brain, liver, and serum variants. J Virol 78:5170–5183 [View Article][PubMed]
    [Google Scholar]
  27. Fox J., Nastouli E., Thomson E., Muir D., McClure M., Weber J., Fidler S. 2008; Increasing incidence of acute hepatitis C in individuals diagnosed with primary HIV in the United Kingdom. AIDS 22:666–668 [View Article][PubMed]
    [Google Scholar]
  28. Gaud U., Langer B., Petropoulou T., Thomas H. C., Karayiannis P. 2003; Changes in hypervariable region 1 of the envelope 2 glycoprotein of hepatitis C virus in children and adults with humoral immune defects. J Med Virol 69:350–356 [View Article][PubMed]
    [Google Scholar]
  29. Gerlach J. T., Ulsenheimer A., Grüner N. H., Jung M. C., Schraut W., Schirren C. A., Heeg M., Scholz S., Witter K. et al. other authors 2005; Minimal T-cell-stimulatory sequences and spectrum of HLA restriction of immunodominant CD4+ T-cell epitopes within hepatitis C virus NS3 and NS4 proteins. J Virol 79:12425–12433 [View Article][PubMed]
    [Google Scholar]
  30. Ghosn J., Pierre-François S., Thibault V., Duvivier C., Tubiana R., Simon A., Valantin M. A., Dominguez S., Caumes E., Katlama C. 2004; Acute hepatitis C in HIV-infected men who have sex with men. HIV Med 5:303–306 [View Article][PubMed]
    [Google Scholar]
  31. Gilleece Y. C., Browne R. E., Asboe D., Atkins M., Mandalia S., Bower M., Gazzard B. G., Nelson M. R. 2005; Transmission of hepatitis C virus among HIV-positive homosexual men and response to a 24-week course of pegylated interferon and ribavirin. J Acquir Immune Defic Syndr 40:41–46 [View Article][PubMed]
    [Google Scholar]
  32. Grakoui A., Shoukry N. H., Woollard D. J., Han J. H., Hanson H. L., Ghrayeb J., Murthy K. K., Rice C. M., Walker C. M. 2003; HCV persistence and immune evasion in the absence of memory T cell help. Science 302:659–662 [View Article][PubMed]
    [Google Scholar]
  33. Gray R. R., Parker J., Lemey P., Salemi M., Katzourakis A., Pybus O. G. 2011; The mode and tempo of hepatitis C virus evolution within and among hosts. BMC Evol Biol 11:131 [View Article][PubMed]
    [Google Scholar]
  34. Harcourt G., Hellier S., Bunce M., Satsangi J., Collier J., Chapman R., Phillips R., Klenerman P. 2001; Effect of HLA class II genotype on T helper lymphocyte responses and viral control in hepatitis C virus infection. J Viral Hepat 8:174–179 [View Article][PubMed]
    [Google Scholar]
  35. Jaeckel E., Cornberg M., Wedemeyer H., Santantonio T., Mayer J., Zankel M., Pastore G., Dietrich M., Trautwein C. et al. other authors 2001; Treatment of acute hepatitis C with interferon alfa-2b. N Engl J Med 345:1452–1457 [View Article][PubMed]
    [Google Scholar]
  36. Jo J., Lohmann V., Bartenschlager R., Thimme R. 2011; Experimental models to study the immunobiology of hepatitis C virus. J Gen Virol 92:477–493 [View Article][PubMed]
    [Google Scholar]
  37. Kalinina O., Norder H., Mukomolov S., Magnius L. O. 2002; A natural intergenotypic recombinant of hepatitis C virus identified in St. Petersburg. J Virol 76:4034–4043 [View Article][PubMed]
    [Google Scholar]
  38. Kim A. Y., Lauer G. M., Ouchi K., Addo M. M., Lucas M., Schulze Zur Wiesch J., Timm J., Boczanowski M., Duncan J. E. et al. other authors 2005; The magnitude and breadth of hepatitis C virus-specific CD8+ T cells depend on absolute CD4+ T-cell count in individuals coinfected with HIV-1. Blood 105:1170–1178 [View Article][PubMed]
    [Google Scholar]
  39. Klenerman P., Lechner F., Kantzanou M., Ciurea A., Hengartner H., Zinkernagel R. 2000; Viral escape and the failure of cellular immune responses. Science 289:2003 [View Article][PubMed]
    [Google Scholar]
  40. Kuntzen T., Timm J., Berical A., Lewis-Ximenez L. L., Jones A., Nolan B., Schulze zur Wiesch J., Li B., Schneidewind A. et al. other authors 2007; Viral sequence evolution in acute hepatitis C virus infection. J Virol 81:11658–11668 [View Article][PubMed]
    [Google Scholar]
  41. Lauer G. M., Ouchi K., Chung R. T., Nguyen T. N., Day C. L., Purkis D. R., Reiser M., Kim A. Y., Lucas M. et al. other authors 2002; Comprehensive analysis of CD8+-T-cell responses against hepatitis C virus reveals multiple unpredicted specificities. J Virol 76:6104–6113 [View Article][PubMed]
    [Google Scholar]
  42. Lechner F., Gruener N. H., Urbani S., Uggeri J., Santantonio T., Kammer A. R., Cerny A., Phillips R., Ferrari C. et al. other authors 2000; CD8+ T lymphocyte responses are induced during acute hepatitis C virus infection but are not sustained. Eur J Immunol 30:2479–2487 [View Article][PubMed]
    [Google Scholar]
  43. Loomba R., Rivera M. M., McBurney R., Park Y., Haynes-Williams V., Rehermann B., Alter H. J., Herrine S. K., Liang T. J. et al. other authors 2011; The natural history of acute hepatitis C: clinical presentation, laboratory findings and treatment outcomes. Aliment Pharmacol Ther 33:559–565 [View Article][PubMed]
    [Google Scholar]
  44. López-Labrador F. X., Dove L., Hui C. K., Phung Y., Kim M., Berenguer M., Wright T. L. 2007; Trends for genetic variation of hepatitis C Virus quasispecies in Human Immunodeficiency virus-1 coinfected patients. Virus Res 130:285–291 [View Article][PubMed]
    [Google Scholar]
  45. Luetkemeyer A., Hare C. B., Stansell J., Tien P. C., Charlesbois E., Lum P., Havlir D., Peters M. 2006; Clinical presentation and course of acute hepatitis C infection in HIV-infected patients. J Acquir Immune Defic Syndr 41:31–36 [View Article][PubMed]
    [Google Scholar]
  46. MacQuillan G. C., Niu X., Speers D., English S., Garas G., Harnett G. B., Reed W. D., Allan J. E., Jeffrey G. P. 2004; Does sequencing the PKRBD of hepatitis C virus NS5A predict therapeutic response to combination therapy in an Australian population?. J Gastroenterol Hepatol 19:551–557 [View Article][PubMed]
    [Google Scholar]
  47. Maggi F., Fornai C., Vatteroni M. L., Giorgi M., Morrica A., Pistello M., Cammarota G., Marchi S., Ciccorossi P. et al. other authors 1997; Differences in hepatitis C virus quasispecies composition between liver, peripheral blood mononuclear cells and plasma. J Gen Virol 78:1521–1525[PubMed]
    [Google Scholar]
  48. Matthews G. V., Hellard M., Haber P., Yeung B., Marks P., Baker D., McCaughan G., Sasadeusz J., White P. et al. other authors 2009; Characteristics and treatment outcomes among HIV-infected individuals in the Australian Trial in Acute Hepatitis C. Clin Infect Dis 48:650–658 [View Article][PubMed]
    [Google Scholar]
  49. McKiernan S. M., Hagan R., Curry M., McDonald G. S., Kelly A., Nolan N., Walsh A., Hegarty J., Lawlor E., Kelleher D. 2004; Distinct MHC class I and II alleles are associated with hepatitis C viral clearance, originating from a single source. Hepatology 40:108–114 [View Article][PubMed]
    [Google Scholar]
  50. Moreau I., Levis J., Crosbie O., Kenny-Walsh E., Fanning L. J. 2008; Correlation between pre-treatment quasispecies complexity and treatment outcome in chronic HCV genotype 3a. Virol J 5:78 [View Article][PubMed]
    [Google Scholar]
  51. Nakagawa M., Sakamoto N., Ueyama M., Mogushi K., Nagaie S., Itsui Y., Azuma S., Kakinuma S., Tanaka H. et al. other authors 2010; Mutations in the interferon sensitivity determining region and virological response to combination therapy with pegylated-interferon alpha 2b plus ribavirin in patients with chronic hepatitis C-1b infection. J Gastroenterol 45:656–665 [View Article][PubMed]
    [Google Scholar]
  52. Natarajan V., Kottilil S., Hazen A., Adelsberger J., Murphy A. A., Polis M. A., Kovacs J. A. 2010; HCV in peripheral blood mononuclear cells are predominantly carried on the surface of cells in HIV/HCV co-infected individuals. J Med Virol 82:2032–2037 [View Article][PubMed]
    [Google Scholar]
  53. Nattermann J., Vogel M., Nischalke H. D., Danta M., Mauss S., Stellbrink H. J., Baumgarten A., Mayr C., Bruno R. et al. other authors 2011; Genetic variation in IL28B and treatment-induced clearance of hepatitis C virus in HIV-positive patients with acute and chronic hepatitis C. J Infect Dis 203:595–601 [View Article][PubMed]
    [Google Scholar]
  54. Neukam K., Nattermann J., Rallón N., Rivero A., Caruz A., Macías J., Vogel M., Benito J., Camacho A. et al. other authors 2011; Different distributions of hepatitis C virus genotypes among HIV-infected patients with acute and chronic hepatitis C according to interleukin-28B genotype. HIV Medno [View Article][PubMed]
    [Google Scholar]
  55. Neumann A. U., Lam N. P., Dahari H., Gretch D. R., Wiley T. E., Layden T. J., Perelson A. S. 1998; Hepatitis C viral dynamics in vivo and the antiviral efficacy of interferon-alpha therapy. Science 282:103–107 [View Article][PubMed]
    [Google Scholar]
  56. Neumann-Haefelin C., Spangenberg H. C., Blum H. E., Thimme R. 2007; Host and viral factors contributing to CD8+ T cell failure in hepatitis C virus infection. World J Gastroenterol 13:4839–4847[PubMed]
    [Google Scholar]
  57. Nguyen O. K., Dore G. J., Kaldor J. M., Hellard M. E. ATAHC Protocol Steering Committee 2007; Recruitment and follow-up of injecting drug users in the setting of early hepatitis C treatment: insights from the ATAHC study. Int J Drug Policy 18:447–451 [View Article][PubMed]
    [Google Scholar]
  58. Page K., Hahn J. A., Evans J., Shiboski S., Lum P., Delwart E., Tobler L., Andrews W., Avanesyan L. et al. other authors 2009; Acute hepatitis C virus infection in young adult injection drug users: a prospective study of incident infection, resolution, and reinfection. J Infect Dis 200:1216–1226 [View Article][PubMed]
    [Google Scholar]
  59. Pascu M., Martus P., Höhne M., Wiedenmann B., Hopf U., Schreier E., Berg T. 2004; Sustained virological response in hepatitis C virus type 1b infected patients is predicted by the number of mutations within the NS5A-ISDR: a meta-analysis focused on geographical differences. Gut 53:1345–1351 [View Article][PubMed]
    [Google Scholar]
  60. Peters L., Weis N. M., Lindhardt B. O. 2006; [Sexual transmission of hepatitis C among HIV-positive men]. Ugeskr Laeger 168:3630–3631 (in Danish) [PubMed]
    [Google Scholar]
  61. Pfafferott K., Gaudieri S., Ulsenheimer A., James I., Heeg M., Nolan D., John M., Rauch A., Mallal S. et al. other authors 2011; Constrained pattern of viral evolution in acute and early HCV infection limits viral plasticity. PLoS ONE 6:e16797 [View Article][PubMed]
    [Google Scholar]
  62. Pham S. T., Bull R. A., Bennett J. M., Rawlinson W. D., Dore G. J., Lloyd A. R., White P. A. 2010; Frequent multiple hepatitis C virus infections among injection drug users in a prison setting. Hepatology 52:1564–1572 [View Article][PubMed]
    [Google Scholar]
  63. Rauch A., Martin M., Weber R., Hirschel B., Tarr P. E., Bucher H. C., Vernazza P., Bernasconi E., Zinkernagel A. S. et al. other authors 2005; Unsafe sex and increased incidence of hepatitis C virus infection among HIV-infected men who have sex with men: the Swiss HIV Cohort Study. Clin Infect Dis 41:395–402 [View Article][PubMed]
    [Google Scholar]
  64. Roque Afonso A. M., Jiang J., Penin F., Tareau C., Samuel D., Petit M. A., Bismuth H., Dussaix E., Féray C. 1999; Nonrandom distribution of hepatitis C virus quasispecies in plasma and peripheral blood mononuclear cell subsets. J Virol 73:9213–9221[PubMed]
    [Google Scholar]
  65. Ruys T. A., den Hollander J. G., Beld M. G., van der Ende M. E., van der Meer J. T. 2004; [Sexual transmission of hepatitis C in homosexual men]. Ned Tijdschr Geneeskd 148:2309–2312 (in Dutch) [PubMed]
    [Google Scholar]
  66. Ruys T. A., Nanlohy N. M., van den Berg C. H., Hassink E., Beld M., van de Laar T., Bruisten S., Wit F., Krol A. et al. other authors 2008; HCV-specific T-cell responses in injecting drug users: evidence for previous exposure to HCV and a role for CD4+ T cells focussing on nonstructural proteins in viral clearance. J Viral Hepat 15:409–420 [View Article][PubMed]
    [Google Scholar]
  67. Santantonio T., Medda E., Ferrari C., Fabris P., Cariti G., Massari M., Babudieri S., Toti M., Francavilla R. et al. other authors 2006; Risk factors and outcome among a large patient cohort with community-acquired acute hepatitis C in Italy. Clin Infect Dis 43:1154–1159 [View Article][PubMed]
    [Google Scholar]
  68. Sarobe P., Lasarte J. J., García N., Civeira M. P., Borrás-Cuesta F., Prieto J. 2006; Characterization of T-cell responses against immunodominant epitopes from hepatitis C virus E2 and NS4a proteins. J Viral Hepat 13:47–55 [View Article][PubMed]
    [Google Scholar]
  69. Schmidt A. J., Rockstroh J. K., Vogel M., An der Heiden M., Baillot A., Krznaric I., Radun D. 2011; Trouble with bleeding: risk factors for acute hepatitis C among HIV-positive gay men from Germany–a case-control study. PLoS ONE 6:e17781 [View Article][PubMed]
    [Google Scholar]
  70. Schnuriger A., Dominguez S., Guiguet M., Harfouch S., Samri A., Ouazene Z., Slama L., Simon A., Valantin M. A. et al. other authors 2009; Acute hepatitis C in HIV-infected patients: rare spontaneous clearance correlates with weak memory CD4 T-cell responses to hepatitis C virus. AIDS 23:2079–2089 [View Article][PubMed]
    [Google Scholar]
  71. Sentandreu V., Jiménez-Hernández N., Torres-Puente M., Bracho M. A., Valero A., Gosalbes M. J., Ortega E., Moya A., González-Candelas F. 2008; Evidence of recombination in intrapatient populations of hepatitis C virus. PLoS ONE 3:e3239 [View Article][PubMed]
    [Google Scholar]
  72. Serpaggi J., Chaix M. L., Batisse D., Dupont C., Vallet-Pichard A., Fontaine H., Viard J. P., Piketty C., Rouveix E. et al. other authors 2006; Sexually transmitted acute infection with a clustered genotype 4 hepatitis C virus in HIV-1-infected men and inefficacy of early antiviral therapy. AIDS 20:233–240 [View Article][PubMed]
    [Google Scholar]
  73. Sheridan I., Pybus O. G., Holmes E. C., Klenerman P. 2004; High-resolution phylogenetic analysis of hepatitis C virus adaptation and its relationship to disease progression. J Virol 78:3447–3454 [View Article][PubMed]
    [Google Scholar]
  74. Shirai M., Arichi T., Chen M., Masaki T., Nishioka M., Ikeda K., Takahashi H., Enomoto N., Saito T. et al. other authors 1999; T cell recognition of hypervariable region-1 from hepatitis C virus envelope protein with multiple class II MHC molecules in mice and humans: preferential help for induction of antibodies to the hypervariable region. J Immunol 162:568–576[PubMed]
    [Google Scholar]
  75. Shire N. J., Horn P. S., Rouster S. D., Stanford S., Eyster M. E., Sherman K. E. Multicenter Hemophilia Cohort HCV Study Group 2006; HCV kinetics, quasispecies, and clearance in treated HCV-infected and HCV/HIV-1-coinfected patients with hemophilia. Hepatology 44:1146–1157 [View Article][PubMed]
    [Google Scholar]
  76. Shores N. J., Maida I., Soriano V., Núnez M. 2008; Sexual transmission is associated with spontaneous HCV clearance in HIV-infected patients. J Hepatol 49:323–328 [View Article][PubMed]
    [Google Scholar]
  77. Shoukry N. H., Cawthon A. G., Walker C. M. 2004; Cell-mediated immunity and the outcome of hepatitis C virus infection. Annu Rev Microbiol 58:391–424 [CrossRef]
    [Google Scholar]
  78. Smith J. A., Aberle J. H., Fleming V. M., Ferenci P., Thomson E. C., Karayiannis P., McLean A. R., Holzmann H., Klenerman P. 2010; Dynamic coinfection with multiple viral subtypes in acute hepatitis C. J Infect Dis 202:1770–1779 [View Article][PubMed]
    [Google Scholar]
  79. Stolte I. G., Dukers N. H., Geskus R. B., Coutinho R. A., de Wit J. B. 2004; Homosexual men change to risky sex when perceiving less threat of HIV/AIDS since availability of highly active antiretroviral therapy: a longitudinal study. AIDS 18:303–309 [View Article][PubMed]
    [Google Scholar]
  80. Tanaka Y., Nishida N., Sugiyama M., Kurosaki M., Matsuura K., Sakamoto N., Nakagawa M., Korenaga M., Hino K. et al. other authors 2009; Genome-wide association of IL28B with response to pegylated interferon-alpha and ribavirin therapy for chronic hepatitis C. Nat Genet 41:1105–1109 [View Article][PubMed]
    [Google Scholar]
  81. Thomas D. L., Thio C. L., Martin M. P., Qi Y., Ge D., O’Huigin C., Kidd J., Kidd K., Khakoo S. I. et al. other authors 2009; Genetic variation in IL28B and spontaneous clearance of hepatitis C virus. Nature 461:798–801 [View Article][PubMed]
    [Google Scholar]
  82. Thomson E. C., Fleming V. M., Main J., Klenerman P., Weber J., Eliahoo J., Smith J., McClure M. O., Karayiannis P. 2011; Predicting spontaneous clearance of acute hepatitis C virus in a large cohort of HIV-1-infected men. Gut 60:837–845[PubMed] [CrossRef]
    [Google Scholar]
  83. Thursz M., Yallop R., Goldin R., Trepo C., Thomas H. C. The HENCORE Group 1999; Influence of MHC class II genotype on outcome of infection with hepatitis C virus. Lancet 354:2119–2124 [View Article][PubMed]
    [Google Scholar]
  84. Torriani F. J., Rodriguez-Torres M., Rockstroh J. K., Lissen E., Gonzalez-García J., Lazzarin A., Carosi G., Sasadeusz J., Katlama C. et al. other authors 2004; Peginterferon Alfa-2a plus ribavirin for chronic hepatitis C virus infection in HIV-infected patients. N Engl J Med 351:438–450 [View Article][PubMed]
    [Google Scholar]
  85. Tuplin A., Evans D. J., Simmonds P. 2004; Detailed mapping of RNA secondary structures in core and NS5B-encoding region sequences of hepatitis C virus by RNase cleavage and novel bioinformatic prediction methods. J Gen Virol 85:3037–3047 [View Article][PubMed]
    [Google Scholar]
  86. Ueda E., Enomoto N., Sakamoto N., Hamano K., Sato C., Izumi N., Watanabe M. 2004; Changes of HCV quasispecies during combination therapy with interferon and ribavirin. Hepatol Res 29:89–96 [View Article][PubMed]
    [Google Scholar]
  87. Urbani S., Amadei B., Tola D., Massari M., Schivazappa S., Missale G., Ferrari C. 2006; PD-1 expression in acute hepatitis C virus (HCV) infection is associated with HCV-specific CD8 exhaustion. J Virol 80:11398–11403 [View Article][PubMed]
    [Google Scholar]
  88. Urbanus A. T., van de Laar T. J., Stolte I. G., Schinkel J., Heijman T., Coutinho R. A., Prins M. 2009; Hepatitis C virus infections among HIV-infected men who have sex with men: an expanding epidemic. AIDS 23:F1–F7 [View Article][PubMed]
    [Google Scholar]
  89. van de Laar T., Pybus O., Bruisten S., Brown D., Nelson M., Bhagani S., Vogel M., Baumgarten A., Chaix M. L. et al. other authors 2009a; Evidence of a large, international network of HCV transmission in HIV-positive men who have sex with men. Gastroenterology 136:1609–1617 [CrossRef]
    [Google Scholar]
  90. van de Laar T. J., Molenkamp R., van den Berg C., Schinkel J., Beld M. G., Prins M., Coutinho R. A., Bruisten S. M. 2009b; Frequent HCV reinfection and superinfection in a cohort of injecting drug users in Amsterdam. J Hepatol 51:667–674 [View Article][PubMed]
    [Google Scholar]
  91. van den Berg C. H., Ruys T. A., Nanlohy N. M., Geerlings S. E., van der Meer J. T., Mulder J. W., Lange J. A., van Baarle D. 2009; Comprehensive longitudinal analysis of hepatitis C virus (HCV)-specific T cell responses during acute HCV infection in the presence of existing HIV-1 infection. J Viral Hepat 16:239–248 [View Article][PubMed]
    [Google Scholar]
  92. Vogel M., Bieniek B., Jessen H., Schewe C. K., Hoffmann C., Baumgarten A., Kroidl A., Bogner J. R., Spengler U., Rockstroh J. K. 2005; Treatment of acute hepatitis C infection in HIV-infected patients: a retrospective analysis of eleven cases. J Viral Hepat 12:207–211 [View Article][PubMed]
    [Google Scholar]
  93. Vogel M., Boesecke C., Rockstroh J. K. 2011; Acute hepatitis C infection in HIV-positive patients. Curr Opin Infect Dis 24:1–6 [View Article][PubMed]
    [Google Scholar]
  94. Weiner A. J., Brauer M. J., Rosenblatt J., Richman K. H., Tung J., Crawford K., Bonino F., Saracco G., Choo Q. L., Houghton M. 1991; Variable and hypervariable domains are found in the regions of HCV corresponding to the flavivirus envelope and NS1 proteins and the pestivirus envelope glycoproteins. Virology 180:842–848 [View Article][PubMed]
    [Google Scholar]
  95. Zajac A. J., Blattman J. N., Murali-Krishna K., Sourdive D. J., Suresh M., Altman J. D., Ahmed R. 1998; Viral immune evasion due to persistence of activated T cells without effector function. J Exp Med 188:2205–2213 [View Article][PubMed]
    [Google Scholar]
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