1887

Abstract

The complete nucleotide sequence of an isolate of simian adenovirus 7 (SAdV-7) was determined. The genome organization of this isolate was found to be similar to that of other primate adenoviruses with two principal notable points: severe truncation of the E1A and E1B 19K proteins and an E3 region encoding only the 12.5K homologue. The viral gene products of SAdV-7 are most closely related to simian adenovirus 1 (SAdV-1), and like SAdV-1, are related to the human adenovirus species HAdV-F, such as the enteric adenoviruses HAdV-40 and HAdV-41 and the recently defined HAdV-G (HAdV-52). Two kinds of gene transfer vectors were made: a replication-competent SAdV-7-based vector with no genomic deletion, and a standard replication-incompetent vector deleted for E1. Importantly, the E1-deleted vector could be propagated to high titre by -complementation in human HEK 293 cells.

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2011-08-01
2019-12-08
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References

  1. Abrahamsen K., Kong H. L., Mastrangeli A., Brough D., Lizonova A., Crystal R. G., Falck-Pedersen E.. ( 1997;). Construction of an adenovirus type 7a E1A- vector. . J Virol 71:, 8946–8951.[PubMed]
    [Google Scholar]
  2. Berk A. J.. ( 2005;). Recent lessons in gene expression, cell cycle control, and cell biology from adenovirus. . Oncogene 24:, 7673–7685. [CrossRef].[PubMed]
    [Google Scholar]
  3. Chanda P. K., Natuk R. J., Mason B. B., Bhat B. M., Greenberg L., Dheer S. K., Molnar-Kimber K. L., Mizutani S., Lubeck M. D. et al. ( 1990;). High level expression of the envelope glycoproteins of the human immunodeficiency virus type I in presence of rev gene using helper-independent adenovirus type 7 recombinants. . Virology 175:, 535–547. [CrossRef].[PubMed]
    [Google Scholar]
  4. Davison A. J., Benko M., Harrach B.. ( 2003;). Genetic content and evolution of adenoviruses. . J Gen Virol 84:, 2895–2908. [CrossRef].[PubMed]
    [Google Scholar]
  5. Gao W., Robbins P. D., Gambotto A.. ( 2003;). Human adenovirus type 35: nucleotide sequence and vector development. . Gene Ther 10:, 1941–1949. [CrossRef].[PubMed]
    [Google Scholar]
  6. Holterman L., Vogels R., van der Vlugt R., Sieuwerts M., Grimbergen J., Kaspers J., Geelen E., van der Helm E., Lemckert A. et al. ( 2004;). Novel replication-incompetent vector derived from adenovirus type 11 (Ad11) for vaccination and gene therapy: low seroprevalence and non-cross-reactivity with Ad5. . J Virol 78:, 13207–13215. [CrossRef].[PubMed]
    [Google Scholar]
  7. Hull R. N., Minner J. R., Mascoli C. C.. ( 1958;). New viral agents recovered from tissue cultures of monkey kidney cells. III. Recovery of additional agents both from cultures of monkey tissues and directly from tissues and excreta. . Am J Hyg 68:, 31–44.[PubMed]
    [Google Scholar]
  8. Jones M. S. II, Harrach B., Ganac R. D., Gozum M. M., Dela Cruz W. P., Riedel B., Pan C., Delwart E. L., Schnurr D. P.. ( 2007;). New adenovirus species found in a patient presenting with gastroenteritis. . J Virol 81:, 5978–5984. [CrossRef].[PubMed]
    [Google Scholar]
  9. Kovács G. M., Davison A. J., Zakhartchouk A. N., Harrach B.. ( 2004;). Analysis of the first complete genome sequence of an Old World monkey adenovirus reveals a lineage distinct from the six human adenovirus species. . J Gen Virol 85:, 2799–2807. [CrossRef].[PubMed]
    [Google Scholar]
  10. Kovács G. M., Harrach B., Zakhartchouk A. N., Davison A. J.. ( 2005;). Complete genome sequence of simian adenovirus 1: an Old World monkey adenovirus with two fiber genes. . J Gen Virol 86:, 1681–1686. [CrossRef].[PubMed]
    [Google Scholar]
  11. Pelka P., Ablack J. N., Fonseca G. J., Yousef A. F., Mymryk J. S.. ( 2008;). Intrinsic structural disorder in adenovirus E1A: a viral molecular hub linking multiple diverse processes. . J Virol 82:, 7252–7263. [CrossRef].[PubMed]
    [Google Scholar]
  12. Rapoza N. P.. ( 1967;). A classification of simian adenoviruses based on hemagglutination. . Am J Epidemiol 86:, 736–745.[PubMed]
    [Google Scholar]
  13. Roy S., Gao G., Lu Y., Zhou X., Lock M., Calcedo R., Wilson J. M.. ( 2004;). Characterization of a family of chimpanzee adenoviruses and development of molecular clones for gene transfer vectors. . Hum Gene Ther 15:, 519–530. [CrossRef].[PubMed]
    [Google Scholar]
  14. Roy S., Zhi Y., Kobinger G. P., Figueredo J., Calcedo R., Miller J. R., Feldmann H., Wilson J. M.. ( 2006;). Generation of an adenoviral vaccine vector based on simian adenovirus 21. . J Gen Virol 87:, 2477–2485. [CrossRef].[PubMed]
    [Google Scholar]
  15. Roy S., Vandenberghe L. H., Kryazhimskiy S., Grant R., Calcedo R., Yuan X., Keough M., Sandhu A., Wang Q. et al. ( 2009;). Isolation and characterization of adenoviruses persistently shed from the gastrointestinal tract of non-human primates. . PLoS Pathog 5:, e1000503. [CrossRef].[PubMed]
    [Google Scholar]
  16. Schneider J. F., Fisher F., Goding C. R., Jones N. C.. ( 1987;). Mutational analysis of the adenovirus E1a gene: the role of transcriptional regulation in transformation. . EMBO J 6:, 2053–2060.[PubMed]
    [Google Scholar]
  17. Seshidhar Reddy P., Ganesh S., Limbach M. P., Brann T., Pinkstaff A., Kaloss M., Kaleko M., Connelly S.. ( 2003;). Development of adenovirus serotype 35 as a gene transfer vector. . Virology 311:, 384–393. [CrossRef].[PubMed]
    [Google Scholar]
  18. Sirena D., Ruzsics Z., Schaffner W., Greber U. F., Hemmi S.. ( 2005;). The nucleotide sequence and a first generation gene transfer vector of species B human adenovirus serotype 3. . Virology 343:, 283–298. [CrossRef].[PubMed]
    [Google Scholar]
  19. Stone D., Ni S., Li Z. Y., Gaggar A., DiPaolo N., Feng Q., Sandig V., Lieber A.. ( 2005;). Development and assessment of human adenovirus type 11 as a gene transfer vector. . J Virol 79:, 5090–5104. [CrossRef].[PubMed]
    [Google Scholar]
  20. Vogels R., Zuijdgeest D., van Rijnsoever R., Hartkoorn E., Damen I., de Béthune M. P., Kostense S., Penders G., Helmus N. et al. ( 2003;). Replication-deficient human adenovirus type 35 vectors for gene transfer and vaccination: efficient human cell infection and bypass of preexisting adenovirus immunity. . J Virol 77:, 8263–8271. [CrossRef].[PubMed]
    [Google Scholar]
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