%0 Journal Article %A Kuri, Thomas %A Eriksson, Klara K. %A Putics, Akos %A Züst, Roland %A Snijder, Eric J. %A Davidson, Andrew D. %A Siddell, Stuart G. %A Thiel, Volker %A Ziebuhr, John %A Weber, Friedemann %T The ADP-ribose-1″-monophosphatase domains of severe acute respiratory syndrome coronavirus and human coronavirus 229E mediate resistance to antiviral interferon responses %D 2011 %J Journal of General Virology, %V 92 %N 8 %P 1899-1905 %@ 1465-2099 %R https://doi.org/10.1099/vir.0.031856-0 %I Microbiology Society, %X Several plus-strand RNA viruses encode proteins containing macrodomains. These domains possess ADP-ribose-1″-phosphatase (ADRP) activity and/or bind poly(ADP-ribose), poly(A) or poly(G). The relevance of these activities in the viral life cycle has not yet been resolved. Here, we report that genetically engineered mutants of severe acute respiratory syndrome coronavirus (SARS-CoV) and human coronavirus 229E (HCoV-229E) expressing ADRP-deficient macrodomains displayed an increased sensitivity to the antiviral effect of alpha interferon compared with their wild-type counterparts. The data suggest that macrodomain-associated ADRP activities may have a role in viral escape from the innate immune responses of the host. %U https://www.microbiologyresearch.org/content/journal/jgv/10.1099/vir.0.031856-0