RT Journal Article SR Electronic(1) A1 Martella, Vito A1 Moschidou, Paschalina A1 Lorusso, Eleonora A1 Mari, Viviana A1 Camero, Michele A1 Bellacicco, Annalucia A1 Losurdo, Michele A1 Pinto, Pierfrancesco A1 Desario, Costantina A1 Bányai, Kristian A1 Elia, Gabriella A1 Decaro, Nicola A1 Buonavoglia, CanioYR 2011 T1 Detection and characterization of canine astroviruses JF Journal of General Virology, VO 92 IS 8 SP 1880 OP 1887 DO https://doi.org/10.1099/vir.0.029025-0 PB Microbiology Society, SN 1465-2099, AB Astroviruses (AstVs) have been identified only occasionally in dogs. A canine AstV, strain Bari/08/ITA, was detected from a pup with gastroenteric signs and the virus was isolated in cell culture and characterized molecularly. In the full-length capsid protein, the virus displayed genetic similarities (83.5 % aa identity) to another canine AstV strain, although a high rate of variation occurred in the hypervariable domain, which is related to AstV antigenic specificity. Specific antibodies were detected in the convalescent dog, indicating seroconversion, and in 59 % of a collection of dog serum samples. Using primers specific for canine AstV, designed to detect a conserved region of ORF1b, canine AstVs were detected in 24.5 % of young pups with gastroenteritis, either alone or in mixed infections with other canine pathogens. In contrast, AstVs were detected in only 9.3 % of asymptomatic pups. These findings indicate that canine AstVs are common in dogs and may suggest a possible role as canine enteric pathogens., UL https://www.microbiologyresearch.org/content/journal/jgv/10.1099/vir.0.029025-0