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Journal of General Virology header logo Journal of General Virology

Volume 92, Issue 2

The GB viruses: a review and proposed classification of GBV-A, GBV-C (HGV), and GBV-D in genus within the family Open Access

Abstract

In 1967, it was reported that experimental inoculation of serum from a surgeon (G.B.) with acute hepatitis into tamarins resulted in hepatitis. In 1995, two new members of the family , named GBV-A and GBV-B, were identified in tamarins that developed hepatitis following inoculation with the 11th GB passage. Neither virus infects humans, and a number of GBV-A variants were identified in wild New World monkeys that were captured. Subsequently, a related human virus was identified [named GBV-C or hepatitis G virus (HGV)], and recently a more distantly related virus (named GBV-D) was discovered in bats. Only GBV-B, a second species within the genus (type species hepatitis C virus), has been shown to cause hepatitis; it causes acute hepatitis in experimentally infected tamarins. The other GB viruses have however not been assigned to a genus within the family . Based on phylogenetic relationships, genome organization and pathogenic features of the GB viruses, we propose to classify GBV-A-like viruses, GBV-C and GBV-D as members of a fourth genus in the family , named (pe, persistent; g, GB or G). We also propose renaming ‘GB’ viruses within the tentative genus to reflect their host origin.

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2011-02-01
2025-04-21
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The GB viruses: a review and proposed classification of GBV-A, GBV-C (HGV), and GBV-D in genus Pegivirus within the family Flaviviridae
J. Gen. Virol. 92, 233 (2011); https://doi.org/10.1099/vir.0.027490-0
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vol. , part 2, pp. 233 - 246

Alignment of the amino acid sequence of conserved regions of helicase

Alignment of the amino acid sequence of conserved regions of RdRp [Single PDF file](132 KB)

 

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