The Israeli acute paralysis virus (IAPV) is a significant marker of honeybee colony collapse disorder (CCD). In the present work, we provide the first evidence that is IAPV replication-competent and capable of vectoring IAPV in honeybees. The honeybees became infected with IAPV after exposure to mites that carried the virus. The copy number of IAPV in bees was positively correlated with the density of mites and time period of exposure to mites. Further, we showed that the mite–virus association could possibly reduce host immunity and therefore promote elevated levels of virus replication. This study defines an active role of mites in IAPV transmission and sheds light on the epidemiology of IAPV infection in honeybees.


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vol. , part 1, pp. 151 - 155

Amplification plot of qPCR assay for IAPV

The validation of qRT-PCR for relative quantification [Single PDF file](354 KB)

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