1887

Abstract

To identify critical phenotypes that affect avian influenza virus transmission in chickens, we compared the transmissibility of three H5N1 highly pathogenic viruses of different pathogenicity in chickens by monitoring the exact time of death using wireless thermo-sensors. This study showed that, despite quick deaths, the most virulent H5N1 A/chicken/Yamaguchi/7/2004 transmitted quickly in chickens via contact and airborne routes. Intermediate virulent H5N1 A/chicken/Miyazaki/K11/2007 spread moderately and less virulent H5N1 A/duck/Yokohama/aq10/2003, causing severe clinical signs and a long period to death, spread slowly among the animals. The transmissibility was correlated with virus titres of oropharyngeal and cloacal swabs, and the time for swab virus titres to reach 50 % chicken infective dose affected the transmission speed. These results demonstrate that peak virus titres excreted and the time required for virus titres to reach a minimal chicken infectious dose may be the critical phenotypes influencing the transmissibility of highly pathogenicity avian influenza viruses in chickens.

Loading

Article metrics loading...

/content/journal/jgv/10.1099/vir.0.023267-0
2010-09-01
2019-11-12
Loading full text...

Full text loading...

/deliver/fulltext/jgv/91/9/2302.html?itemId=/content/journal/jgv/10.1099/vir.0.023267-0&mimeType=html&fmt=ahah

References

  1. Alexander, D. J. ( 2007a; ). An overview of the epidemiology of avian influenza. Vaccine 25, 5637–5644.[CrossRef]
    [Google Scholar]
  2. Alexander, D. J. ( 2007b; ). Summary of avian influenza activity in Europe, Asia, Africa, and Australasia, 2002–2006. Avian Dis 51, 161–166.[CrossRef]
    [Google Scholar]
  3. Alexander, D. J., Parsons, G. & Manvell, R. J. ( 1986; ). Experimental assessment of the pathogenicity of eight avian influenza A viruses of H5 subtype for chickens, turkeys, ducks and quail. Avian Pathol 15, 647–662.[CrossRef]
    [Google Scholar]
  4. Forman, A. J., Parsonson, I. M. & Doughty, W. J. ( 1986; ). The pathogenicity of an avian influenza virus isolated in Victoria. Aust Vet J 63, 294–296.[CrossRef]
    [Google Scholar]
  5. Lowen, A. C., Mubareka, S., Tumpey, T. M., Garcia-Sastre, A. & Palese, P. ( 2006; ). The guinea pig as a transmission model for human influenza viruses. Proc Natl Acad Sci U S A 103, 9988–9992.[CrossRef]
    [Google Scholar]
  6. Lowen, A. C., Mubareka, S., Steel, J. & Palese, P. ( 2007; ). Influenza virus transmission is dependent on relative humidity and temperature. PLoS Pathog 3, 1470–1476.
    [Google Scholar]
  7. Lowen, A. C., Steel, J., Mubareka, S. & Palese, P. ( 2008; ). High temperature (30 °C) blocks aerosol but not contact transmission of influenza virus. J Virol 82, 5650–5652.[CrossRef]
    [Google Scholar]
  8. Maines, T. R., Chen, L. M., Matsuoka, Y., Chen, H., Rowe, T., Ortin, J., Falcon, A., Nguyen, T. H., Mai, L. Q. & other authors ( 2006; ). Lack of transmission of H5N1 avian-human reassortant influenza viruses in a ferret model. Proc Natl Acad Sci U S A 103, 12121–12126.[CrossRef]
    [Google Scholar]
  9. Mase, M., Eto, M., Tanimura, N., Imai, K., Tsukamoto, K., Horimoto, T., Kawaoka, Y. & Yamaguchi, S. ( 2005a; ). Isolation of a genotypically unique H5N1 influenza virus from duck meat imported into Japan from China. Virology 339, 101–109.[CrossRef]
    [Google Scholar]
  10. Mase, M., Tsukamoto, K., Imada, T., Imai, K., Tanimura, N., Nakamura, K., Yamamoto, Y., Hitomi, T., Kira, T. & other authors ( 2005b; ). Characterization of H5N1 influenza A viruses isolated during the 2003–2004 influenza outbreaks in Japan. Virology 332, 167–176.[CrossRef]
    [Google Scholar]
  11. Okamatsu, M., Saito, T., Yamamoto, Y., Mase, M., Tsuduku, S., Nakamura, K., Tsukamoto, K. & Yamaguchi, S. ( 2007; ). Low pathogenicity H5N2 avian influenza outbreak in Japan during the 2005–2006. Vet Microbiol 124, 35–46.[CrossRef]
    [Google Scholar]
  12. Reed, L. & Muench, H. ( 1938; ). A simple method of estimating fifty percent endpoints. Am J Hyg 27, 493–497.
    [Google Scholar]
  13. Senne, D. A. ( 2007; ). Avian influenza in North and South America, 2002–2005. Avian Dis 51, 167–173.[CrossRef]
    [Google Scholar]
  14. Suzuki, K., Okada, H., Itoh, T., Tada, T., Mase, M., Nakamura, K., Kubo, M. & Tsukamoto, K. ( 2009; ). Association of increased pathogenicity of Asian H5N1 highly pathogenic avian influenza viruses in chickens with highly efficient viral replication accompanied by early destruction of innate immune responses. J Virol 83, 7475–7486.[CrossRef]
    [Google Scholar]
  15. Swayne, D. E. ( 1997; ). Pathobiology of H5N2 Mexican avian influenza virus infections of chickens. Vet Pathol 34, 557–567.[CrossRef]
    [Google Scholar]
  16. Swayne, D. E. ( 2007; ). Understanding the complex pathobiology of high pathogenicity avian influenza viruses in birds. Avian Dis 51, 242–249.[CrossRef]
    [Google Scholar]
  17. Swayne, D. E. & Halvorso, D. A. ( 2003; ). Influenza. In Diseases of Poultry, 11th edn, pp. 135–160. Edited by Y. M. Saif, J. H. Barnes, J. R. Glisson, A. M. Fadly, L. R. McGougald & D. E. Swayne. Ames, Iowa: Iowa State Press.
  18. Swayne, D. E. & Slemons, R. D. ( 2008; ). Using mean infectious dose of high- and low-pathogenicity avian influenza viruses originating from wild duck and poultry as one measure of infectivity and adaptation to poultry. Avian Dis 52, 455–460.[CrossRef]
    [Google Scholar]
  19. Tsukamoto, K., Imada, T., Tanimura, N., Okamatsu, M., Mase, M., Mizuhara, T., Swayne, D. & Yamaguchi, S. ( 2007; ). Impact of different husbandry conditions on contact and airborne transmission of H5N1 highly pathogenic avian influenza virus to chickens. Avian Dis 51, 129–132.[CrossRef]
    [Google Scholar]
  20. van der Goot, J. A., Koch, G., de Jong, M. C. & van Boven, M. ( 2003; ). Transmission dynamics of low- and high-pathogenicity A/Chicken/Pennsylvania/83 avian influenza viruses. Avian Dis 47, 939–941.[CrossRef]
    [Google Scholar]
  21. Westbury, H. A., Turner, A. J. & Amon, L. ( 1981; ). Transmissibility of two avian influenza A viruses (H7N6) between chickens. Avian Pathol 10, 481–487.[CrossRef]
    [Google Scholar]
http://instance.metastore.ingenta.com/content/journal/jgv/10.1099/vir.0.023267-0
Loading
/content/journal/jgv/10.1099/vir.0.023267-0
Loading

Data & Media loading...

Most Cited This Month

This is a required field
Please enter a valid email address
Approval was a Success
Invalid data
An Error Occurred
Approval was partially successful, following selected items could not be processed due to error