1887

Abstract

To investigate the prevalence and evolution of the H5 subtype highly pathogenic avian influenza (HPAI) viruses circulating in poultry in China during 2007–2009, five molecular epidemiological surveys were carried out. A total of 21 591 swab samples were collected, and from them 55 H5 HPAI viruses were isolated. None of the 55 viruses carried any known mutations, which can render the virus binding to human SAa2,6Gal receptors. The surveys indicated that live-bird markets, backyard flocks and slaughtering sites were at greater risk of being infected with the viruses during winter, and Clades 2.3.2, 2.3.4 and 7 of the viruses co-circulated in poultry in China during 2007–2009. Viruses within Clades 2.3.2 and 7 have become genetically distinguishable from the viruses isolated before 2007 and antigenically distinguishable from the vaccine strains used in China. Viruses within Clade 2.3.2 have been circulating widely in China and caused a new wave of cross-continental spreading from Asia to Europe.

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2010-10-01
2019-10-22
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References

  1. Alexander, D. J. & Brown, I. H. ( 2009; ). History of highly pathogenic avian influenza. Rev Sci Tech 28, 19–38.
    [Google Scholar]
  2. Auewarakul, P., Suptawiwat, O., Kongchanagul, A., Sangma, C., Suzuki, Y., Ungchusak, K., Louisirirotchanakul, S., Lerdsamran, H., Pooruk, P. & other authors ( 2007; ). An avian influenza H5N1 virus that binds to a human-type receptor. J Virol 81, 9950–9955.[CrossRef]
    [Google Scholar]
  3. Boltz, D. A., Douangngeun, B., Phommachanh, P., Sinthasak, S., Mondry, R., Obert, C., Seiler, P., Keating, R., Suzuki, Y. & other authors ( 2010; ). Emergence of H5N1 avian influenza viruses with reduced sensitivity to neuraminidase inhibitors and novel reassortants in Lao People's Democratic Republic. J Gen Virol 91, 949–959.[CrossRef]
    [Google Scholar]
  4. Chen, H. ( 2009; ). H5N1 avian influenza in China. Sci China C Life Sci 52, 419–427.[CrossRef]
    [Google Scholar]
  5. Chen, J. M., Chen, J. W., Dai, J. J. & Sun, Y. X. ( 2007; ). A survey of human cases of H5N1 avian influenza reported by the WHO before June 2006 for infection control. Am J Infect Control 35, 351–353.[CrossRef]
    [Google Scholar]
  6. Chen, J., Fang, F., Yang, Z., Liu, X., Zhang, H., Zhang, Z., Zhang, X. & Chen, Z. ( 2009; ). Characterization of highly pathogenic H5N1 avian influenza viruses isolated from poultry markets in central China. Virus Res 146, 19–28.[CrossRef]
    [Google Scholar]
  7. Chen, J. M., Sun, Y. X., Chen, J. W., Liu, S., Yu, J. M., Shen, C. J., Sun, X. D. & Peng, D. ( 2009; ). Panorama phylogenetic diversity and distribution of type A influenza viruses based on their six internal gene sequences. Virol J 6, 137.[CrossRef]
    [Google Scholar]
  8. Domenech, J., Dauphin, G., Rushton, J., McGrane, J., Lubroth, J., Tripodi, A., Gilbert, J. & Sims, L. D. ( 2009; ). Experiences with vaccination in countries endemically infected with highly pathogenic avian influenza: the Food and Agriculture Organization perspective. Rev Sci Tech 28, 293–305.
    [Google Scholar]
  9. Duvvuri, V. R., Duvvuri, B., Cuff, W. R., Wu, G. E. & Wu, J. ( 2009; ). Role of positive selection pressure on the evolution of H5N1 hemagglutinin. Genomics Proteomics Bioinformatics 7, 47–56.[CrossRef]
    [Google Scholar]
  10. Guan, Y., Smith, G. J., Webby, R. & Webster, R. G. ( 2009; ). Molecular epidemiology of H5N1 avian influenza. Rev Sci Tech 28, 39–47.
    [Google Scholar]
  11. Ji, K., Jiang, W. M., Liu, S., Chen, J. M., Chen, J., Hou, G. Y., Li, J. P. & Huang, B. X. ( 2010; ). Characterization of the hemagglutinin gene of subtype H9 avian influenza viruses isolated in 2007–2009 in China. J Virol Methods 163, 186–189.[CrossRef]
    [Google Scholar]
  12. Kaverin, N. V., Rudneva, I. A., Govorkova, E. A., Timofeeva, T. A., Shilov, A. A., Kochergin-Nikitsky, K. S., Krylov, P. S. & Webster, R. G. ( 2007; ). Epitope mapping of the hemagglutinin molecule of a highly pathogenic H5N1 influenza virus by using monoclonal antibodies. J Virol 81, 12911–12917.[CrossRef]
    [Google Scholar]
  13. Kim, H. R., Park, C. K., Lee, Y. J., Woo, G. H., Lee, K. K., Oem, J. K., Kim, S. H., Jean, Y. H., Bae, Y. C. & other authors ( 2010; ). An outbreak of highly pathogenic H5N1 avian influenza in Korea, 2008. Vet Microbiol 141, 362–366.[CrossRef]
    [Google Scholar]
  14. Kou, Z., Li, Y., Yin, Z., Guo, S., Wang, M., Gao, X., Li, P., Tang, L., Jiang, P. & other authors ( 2009; ). The survey of H5N1 flu virus in wild birds in 14 Provinces of China from 2004 to 2007. PLoS ONE 4, e6926.[CrossRef]
    [Google Scholar]
  15. Lee, C. W., Senne, D. A. & Suarez, D. L. ( 2004; ). Effect of vaccine use in the evolution of Mexican lineage H5N2 avian influenza virus. J Virol 78, 8372–8381.[CrossRef]
    [Google Scholar]
  16. Liu, J., Xiao, H., Lei, F., Zhu, Q., Qin, K., Zhang, X. W., Zhang, X. L., Zhao, D., Wang, G. & other authors ( 2005; ). Highly pathogenic H5N1 influenza virus infection in migratory birds. Science 309, 1206.[CrossRef]
    [Google Scholar]
  17. Liu, S., Ji, K., Chen, J., Tai, D., Jiang, W., Hou, G., Chen, J., Li, J. & Huang, B. ( 2009; ). Panorama phylogenetic diversity and distribution of Type A influenza virus. PLoS ONE 4, e5022.[CrossRef]
    [Google Scholar]
  18. Ma, H. C., Chen, J. M., Chen, J. W., Sun, Y. X., Li, J. M. & Wang, Z. L. ( 2007; ). The panorama of the diversity of H5 subtype influenza viruses. Virus Genes 34, 283–287.[CrossRef]
    [Google Scholar]
  19. Neumann, G., Chen, H., Gao, G. F., Shu, Y. & Kawaoka, Y. ( 2010; ). H5N1 influenza viruses: outbreaks and biological properties. Cell Res 20, 51–61.[CrossRef]
    [Google Scholar]
  20. Nguyen, T., Davis, C. T., Stembridge, W., Shu, B., Balish, A., Inui, K., Do, H. T., Ngo, H. T., Wan, X. F. & other authors ( 2009; ). Characterization of a highly pathogenic avian influenza H5N1 virus sublineage in poultry seized at ports of entry into Vietnam. Virology 387, 250–256.[CrossRef]
    [Google Scholar]
  21. Senne, D. A., Panigrahy, B., Kawaoka, Y., Pearson, J. E., Süss, J., Lipkind, M., Kida, H. & Webster, R. G. ( 1996; ). Survey of the hemagglutinin (HA) cleavage site sequence of H5 and H7 avian influenza viruses: amino acid sequence at the HA cleavage site as a marker of pathogenicity potential. Avian Dis 40, 425–437.[CrossRef]
    [Google Scholar]
  22. Smith, G. J., Fan, X. H., Wang, J., Li, K. S., Qin, K., Zhang, J. X., Vijaykrishna, D., Cheung, C. L., Huang, K. & other authors ( 2006; ). Emergence and predominance of an H5N1 influenza variant in China. Proc Natl Acad Sci U S A 103, 16936–16941.[CrossRef]
    [Google Scholar]
  23. Smith, G. J., Vijaykrishna, D., Ellis, T. M., Dyrting, K. C., Leung, Y. H., Bahl, J., Wong, C. W., Kai, H., Chow, M. K. & other authors ( 2009; ). Characterization of avian influenza viruses A (H5N1) from wild birds, Hong Kong, 2004–2008. Emerg Infect Dis 15, 402–407.[CrossRef]
    [Google Scholar]
  24. Stevens, J., Blixt, O., Tumpey, T. M., Taubenberger, J. K., Paulson, J. C. & Wilson, I. A. ( 2006; ). Structure and receptor specificity of the hemagglutinin from an H5N1 influenza virus. Science 312, 404–410.[CrossRef]
    [Google Scholar]
  25. Uchida, Y., Mase, M., Yoneda, K., Kimura, A., Obara, T., Kumagai, S., Saito, T., Yamamoto, Y., Nakamura, K. & other authors ( 2008; ). Highly pathogenic avian influenza virus (H5N1) isolated from whooper swans, Japan. Emerg Infect Dis 14, 1427–1429.[CrossRef]
    [Google Scholar]
  26. WHO/OIE/FAO H5N1 Evolution Working Group ( 2008; ). Toward a unified nomenclature system for highly pathogenic avian influenza virus (H5N1). Emerg Infect Dis 14, e1.
    [Google Scholar]
  27. Wu, W. L., Chen, Y., Wang, P., Song, W., Lau, S. Y., Rayner, J. M., Smith, G. J., Webster, R. G., Peiris, J. S. & other authors ( 2008; ). Antigenic profile of avian H5N1 viruses in Asia from 2002 to 2007. J Virol 82, 1798–1807.[CrossRef]
    [Google Scholar]
  28. Xu, X., Subbarao, K., Cox, N. J. & Guo, Y. ( 1999; ). Genetic characterization of the pathogenic influenza A/Goose/Guangdong/1/96(H5N1) virus: similarity of its hemagglutinin gene to those of H5N1 viruses from the 1997 outbreaks in Hong Kong. Virology 261, 15–19.[CrossRef]
    [Google Scholar]
  29. Xu, C., Dong, L., Xin, L., Lan, Y., Chen, Y., Yang, L. & Shu, Y. ( 2009; ). Human avian influenza A (H5N1) virus infection in China. Sci China C Life Sci 52, 407–411.[CrossRef]
    [Google Scholar]
  30. Yamada, S., Suzuki, Y., Suzuki, T., Le, M. Q., Nidom, C. A., Sakai-Tagawa, Y., Muramoto, Y., Ito, M., Kiso, M. & other authors ( 2006; ). Haemagglutinin mutations responsible for the binding of H5N1 influenza A viruses to human-type receptors. Nature 444, 378–382.[CrossRef]
    [Google Scholar]
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