1887

Abstract

This study investigated the impact of human immunodeficiency virus (HIV) infection on genital human papillomavirus (HPV) in heterosexual couples. More HIV-positive men and women had genital HPV compared with HIV-negative men (77 vs 49 %; <0.001) and women (74 vs 36 %; <0.001). More men and women with partners who were HPV positive had HPV genital infection compared with those with HPV-negative partners (for men, 72 % compared with 40 %; <0.001). Men with HIV-positive female partners were at greater risk of high-risk HPV and low-risk HPV (LR HPV) infection compared with men with HIV-negative female partners. This risk increased with decreasing CD4 count {≥350 ml: odds ratio [OR ], 2.37 [95 % confidence interval (CI), 1.47–3.83]; <350 ml: OR, 3.02 [95 % CI, 1.86–4.9]}. Conversely, the risk of HPV of any type was not found to differ between women with an HIV-positive or HIV-negative male partner. In men, HIV infection and female partner HIV-positive status were both associated with a higher risk of type-specific HPV concordance with their sexual partner, though the associations were not significant for LR HPV. In women, HIV infection and low CD4 count were significantly associated with increased risk of type-specific HPV concordance, but male partner HIV-positive status was not significantly associated with this concordance. In conclusion, male genital HPV prevalence and type-specific sharing were influenced by their own HIV-positive status and that of their female partner. In contrast, female genital HPV prevalence and HPV type-specific sharing were determined by their own HIV-positive status and not by that of their male partner.

Loading

Article metrics loading...

/content/journal/jgv/10.1099/vir.0.020669-0
2010-12-01
2019-11-12
Loading full text...

Full text loading...

/deliver/fulltext/jgv/91/12/3023.html?itemId=/content/journal/jgv/10.1099/vir.0.020669-0&mimeType=html&fmt=ahah

References

  1. Bleeker, M. C. G., Hogewoning, C. J. A., van den Brule, A. J. C., Voorhorst, F. J., van Andel, R. E., Risse, E. K. J., Starink, T. M. & Meijer, C. J. L. M. ( 2002; ). Penile lesions and human papillomavirus in male sexual partners of women with cervical intraepithelial neoplasia. J Am Acad Dermatol 47, 351–357.[CrossRef]
    [Google Scholar]
  2. Bleeker, M. C. G., Hogewoning, C. J. A., Voorhorst, F. J., van den Brule, A. J., Berkhof, J., Hesselink, A. T., Lettink, M., Starink, T. M., Stoof, T. J. & other authors ( 2005; ). HPV-associated flat penile lesions in men of a non-STD hospital population: less frequent and smaller in size than in male sexual partners of women with CIN. Int J Cancer 113, 36–41.[CrossRef]
    [Google Scholar]
  3. Burchell, A. N., Tellier, P. P., Hanley, J., Coutlee, F. & Franco, E. L. ( 2010; ). Influence of partner's infection status on prevalent human papillomavirus among persons with a new sex partner. Sex Transm Dis 37, 34–40.[CrossRef]
    [Google Scholar]
  4. Cuschieri, K. S., Cubie, H. A., Whitley, M. W., Seagar, A. L., Arends, M. J., Moore, C., Gilkisson, G. & McGoogan, E. ( 2004; ). Multiple high risk HPV infections are common in cervical neoplasia and young women in a cervical screening population. J Clin Pathol 57, 68–72.[CrossRef]
    [Google Scholar]
  5. Eckert, L. O., Watts, D. H., Koutsky, L. A., Hawes, S. E., Stevens, C. E., Kuypers, J. & Kiviat, N. B. ( 1999; ). A matched prospective study of human immunodeficiency virus serostatus, human papillomavirus DNA, and cervical lesions detected by cytology and colposcopy. Infect Dis Obstet Gynecol 7, 158–164.[CrossRef]
    [Google Scholar]
  6. Flores, R., Papenfuss, M., Klimecki, W. T. & Giuliano, A. R. ( 2006; ). Cross-sectional analysis of oncogenic HPV viral load and cervical intraepithelial neoplasia. Int J Cancer 118, 1187–1193.[CrossRef]
    [Google Scholar]
  7. Gross, G. & Pfister, H. ( 2004; ). Role of human papillomavirus in penile cancer, penile intraepithelial squamous cell neoplasias and in genital warts. Med Microbiol Immunol (Berl) 193, 35–44.[CrossRef]
    [Google Scholar]
  8. Heard, I., Tassie, J. M., Schmitz, V., Mandelbrot, L., Kazatchkine, M. D. & Orth, G. ( 2000; ). Increased risk of cervical disease among human immunodeficiency virus-infected women with severe immunosuppression and high human papillomavirus load. Obstet Gynecol 96, 403–409.[CrossRef]
    [Google Scholar]
  9. Hernandez, B. Y., Wilkens, L. R., Zhu, X., Thompson, P., McDuffie, K., Shvetsov, Y. B., Kamemoto, L. E., Killeen, J., Ning, L. & Goodman, M. T. ( 2008; ). Transmission of human papillomavirus in heterosexual couples. Emerg Infect Dis 14, 888–894.[CrossRef]
    [Google Scholar]
  10. Jones, H. E., Allan, B. R., De Wijgert, J. H. H. M., Altini, L., Taylor, S. M., de Kock, A., Coetzee, N. & Williamson, A. L. ( 2007; ). Agreement between self- and clinician-collected specimen results for detection and typing of high-risk human papillomavirus in specimens from women in Gugulethu, South Africa. J Clin Microbiol 45, 1679–1683.[CrossRef]
    [Google Scholar]
  11. Jung, W.-W., Chun, T., Sul, D., Hwang, K. W., Kang, H. S., Lee, D. J. & Han, I. K. ( 2004; ). Strategies against human papillomavirus infection and cervical cancer. J Microbiol 42, 255–266.
    [Google Scholar]
  12. Kjaer, S. K., Svare, E. I., Worm, A. M., Walboomers, J. M. M., Meijer, C. J. L. M. & van den Brule, A. J. C. ( 2000; ). Human papillomavirus infection in Danish female sex workers: decreasing prevalence with age despite continuously high sexual activity. Sex Transm Dis 27, 438–445.[CrossRef]
    [Google Scholar]
  13. Kjaer, S. K., Chackerian, B., van den Brule, A. J. C. & other authors ( 2001; ). High-risk human papillomavirus is sexually transmitted: evidence from a follow-up study of virgins starting sexual activity (intercourse). Cancer Epidemiol Biomarkers Prev 10, 101–106.
    [Google Scholar]
  14. Lefevre, J., Hankins, C., Money, D., Rachlis, A., Pourreaux, K. & Coutlee, F. ( 2004; ). Human papillomavirus type 16 viral load is higher in human immunodeficiency virus-seropositive women with high-grade squamous intraepithelial lesions than in those with normal cytology smears. J Clin Microbiol 42, 2212–2215.[CrossRef]
    [Google Scholar]
  15. Levi, J. E., Kleter, B., Quint, W. G. V., Fink, M. C., Canto, C. L., Matsubara, R., Linhares, I., Segurado, A., Vanderborght, B. & other authors ( 2002; ). High prevalence of human papillomavirus (HPV) infections and high frequency of multiple HPV genotypes in human immunodeficiency virus-infected women in Brazil. J Clin Microbiol 40, 3341–3345.[CrossRef]
    [Google Scholar]
  16. Lomalisa, P., Smith, T. & Guidozzi, F. ( 2000; ). Human immunodeficiency virus infection and invasive cervical cancer in South Africa. Gynecol Oncol 77, 460–463.[CrossRef]
    [Google Scholar]
  17. Mbulawa, Z. Z. A., Coetzee, D., Marais, D. J., Kamupira, M., Zwane, E., Allan, B., Constant, D., Moodley, J. R., Hoffman, M. & Williamson, A. L. ( 2009; ). Genital human papillomavirus prevalence and human papillomavirus concordance in heterosexual couples are positively associated with human immunodeficiency virus coinfection. J Infect Dis 199, 1514–1524.[CrossRef]
    [Google Scholar]
  18. Munoz, N., Bosch, F. X., de Sanjose, S., Herrero, R., Castellsague, X., Shah, K. V., Snijders, P. J. F. & Meijer, C. J. L. M. ( 2003; ). Epidemiologic classification of human papillomavirus types associated with cervical cancer. N Engl J Med 348, 518–527.[CrossRef]
    [Google Scholar]
  19. Palefsky, J. M. ( 2007; ). HPV infection in men. Dis Markers 23, 261–272.[CrossRef]
    [Google Scholar]
  20. Palefsky, J. M., Minkoff, H., Kalish, L. A., Levine, A., Sacks, H. S., Garcia, P., Young, M., Melnick, S., Miotti, P. & Burk, R. ( 1999; ). Cervicovaginal human papillomavirus infection in human immunodeficiency virus-1 (HIV)-positive and high-risk HIV-negative women. J Natl Cancer Inst 91, 226–236.[CrossRef]
    [Google Scholar]
  21. Riva, E., Serraino, D., Pierangeli, A., Bambacioni, F., Zaniratti, S., Minosse, C., Selleri, M., Bucci, M., Scagnolari, C. & other authors ( 2007; ). Markers of human papillomavirus infection and their correlation with cervical dysplasia in human immunodeficiency virus-positive women. Clin Microbiol Infect 13, 94–97.[CrossRef]
    [Google Scholar]
  22. Schiffman, M. & Castle, P. E. ( 2005; ). The promise of global cervical-cancer prevention. N Engl J Med 353, 2101–2104.[CrossRef]
    [Google Scholar]
  23. Strickler, H. D., Burk, R. D., Fazzari, M., Anastos, K., Minkoff, H., Massad, L. S., Hall, C., Bacon, M., Levine, A. M. & other authors ( 2005; ). Natural history and possible reactivation of human papillomavirus in human immunodeficiency virus-positive women. J Natl Cancer Inst 97, 577–586.[CrossRef]
    [Google Scholar]
  24. Svare, E. I., Kjaer, S. K., Worm, A. M., Osterlind, A., Meijer, C. J. L. M. & van den Brule, A. J. C. ( 2002; ). Risk factors for genital HPV DNA in men resemble those found in women: a study of male attendees at a Danish STD clinic. Sex Transm Infect 78, 215–218.[CrossRef]
    [Google Scholar]
  25. Winer, R. L., Feng, Q. H., Hughes, J. P., O'Reilly, S., Kiviat, N. B. & Koutsky, L. A. ( 2008; ). Risk of female human papillomavirus acquisition associated with first male sex partner. J Infect Dis 197, 279–282.[CrossRef]
    [Google Scholar]
http://instance.metastore.ingenta.com/content/journal/jgv/10.1099/vir.0.020669-0
Loading
/content/journal/jgv/10.1099/vir.0.020669-0
Loading

Data & Media loading...

Most Cited This Month

This is a required field
Please enter a valid email address
Approval was a Success
Invalid data
An Error Occurred
Approval was partially successful, following selected items could not be processed due to error