@article{mbs:/content/journal/jgv/10.1099/vir.0.020032-0, author = "Li, Yan and Ge, Xingyi and Hon, Chung-Chau and Zhang, Huajun and Zhou, Peng and Zhang, Yunzhi and Wu, Yi and Wang, Lin-Fa and Shi, Zhengli", title = "Prevalence and genetic diversity of adeno-associated viruses in bats from China", journal= "Journal of General Virology", year = "2010", volume = "91", number = "10", pages = "2601-2609", doi = "https://doi.org/10.1099/vir.0.020032-0", url = "https://www.microbiologyresearch.org/content/journal/jgv/10.1099/vir.0.020032-0", publisher = "Microbiology Society", issn = "1465-2099", type = "Journal Article", abstract = "Bats are increasingly being recognized as important natural reservoirs of different viruses. Adeno-associated viruses (AAVs) are widely distributed in primates and their distribution in bats is unknown. In this study, a total of 370 faecal swab samples from 19 bat species were collected from various provinces of China and examined for the presence of AAVs. The mean prevalence rate was 22.4 % (83 positives out of 370 samples), ranging from 10 to 38.9 % among different bat species. The genome sequence spanning the entire rep–cap ORFs was determined from one chosen AAV-positive sample (designated BtAAV-YNM). Phylogenetic analysis of the entire rep–cap ORF coding sequences suggested that BtAAV-YNM is relatively distant to known primate AAVs, but phylogenetically closer to porcine AAV strain Po3. Further analysis of the partial cap ORF sequences of bat AAV samples (n=49) revealed a remarkably large genetic diversity, with an average pairwise nucleotide identity of only 84.3 %. Co-presence of multiple distinctive genotypes of bat AAV within an individual sample was also observed. These results demonstrated that diverse AAVs might be widely distributed in bat populations.", }