RT Journal Article SR Electronic(1) A1 Shinya, Kyoko A1 Makino, Akiko A1 Hatta, Masato A1 Watanabe, Shinji A1 Kim, Jin Hyun A1 Kawaoka, YoshihiroYR 2010 T1 A mutation in H5 haemagglutinin that conferred human receptor recognition is not maintained stably during duck passage JF Journal of General Virology, VO 91 IS 6 SP 1461 OP 1463 DO https://doi.org/10.1099/vir.0.018572-0 PB Microbiology Society, SN 1465-2099, AB A/Hong Kong/213/97 (HK213; H5N1), isolated from a human, binds to both avian- and human-type receptors, due to a haemagglutinin (HA) mutation probably acquired during adaptation to humans. Duck passage of this virus conferred lethality in ducks. Sequence analyses of the duck-passaged virus revealed that its HA gene reverted back to one recognizing only avian-type receptors, and consequently it bound human tissue to a lesser extent. This finding suggests that viruses with human-type receptor specificity are unlikely to be maintained in waterfowl, unlike those with the human-type PB2 mutation, such as H5N1 viruses of the Qinghai Lake lineage., UL https://www.microbiologyresearch.org/content/journal/jgv/10.1099/vir.0.018572-0