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Volume 91, Issue 5

Genomic and phylogenetic characterization of Merino Walk virus, a novel arenavirus isolated in South Africa Free

Abstract

Merino Walk virus (MWV), a proposed novel tentative species of the family , was isolated from a rodent, , collected at Merino Walk, Eastern Cape, South Africa, in 1985. Full-length genomic sequence confirmed MWV as an arenavirus related distantly to Mobala, Mopeia and Ippy viruses, all members of the Old World arenavirus complex. We propose MWV as a tentative novel species in the Lassa–lymphocytic choriomeningitis virus complex, based on its isolation from a novel rodent species and its genetic and serological characteristics.

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2010-05-01
2023-06-10
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Genomic and phylogenetic characterization of Merino Walk virus, a novel arenavirus isolated in South Africa
J. Gen. Virol. 91, 1315 (2010); https://doi.org/10.1099/vir.0.017798-0
/content/journal/jgv/10.1099/vir.0.017798-0
/content/journal/jgv/10.1099/vir.0.017798-0
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vol. , part 5, pp. 1315–1324

Bayesian analyses of Merino Walk virus (MWV), inferred based on the NP nucleotide sequence.

Motifs in the Z protein of MWV conserved with other arenaviruses. The shortened Z protein of MWV contains neither conserved late domain.

Simplot of L segment (a) and motifs (b) in region III (pre-A, A, B, C, D, E) of MWV conserved with other Old World arenaviruses.

Motifs, variable region and zinc-finger domain in the nucleocapsid protein of MWV conserved with other arenaviruses.

Simplot of the M segment (a) with other Old World arenaviruses and conserved motifs (b) among the signal sequence, G1 and G2 proteins.

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