1887

Abstract

Serological screening of sera from orang-utans demonstrated a high percentage of sera that cross-reacted with antigens of the polyomavirus (PyV) simian virus 40. Analysis of archival DNA samples from 71 Bornean and eight Sumatran orang-utans with a broad-spectrum PCR assay resulted in the detection of PyV infections in 11 animals from both species. Sequence analysis of the amplicons revealed considerable differences between the PyVs from Bornean and Sumatran orang-utans. The genome from two PyVs, one from each species, was therefore amplified and sequenced. Both viral genomes revealed a characteristic PyV architecture, but lacked an obvious agnogene. Neighbour-joining analysis positioned the viruses in a large cluster together with viruses from bats, bovines, rodents and several primate PyVs from chimpanzees, African green monkeys, squirrel monkeys and the human Merkel cell PyV.

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2010-03-01
2019-11-18
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Supplements

vol. , part 3, pp. 653–658

Alignment of PyV VP1 nucleotide sequences obtained from Bornean and Sumatran orang-utans.

Comparison of full-length VP1 genes obtained from Bornean and Sumatran orang-utans.

Alignment of full-length VP1 proteins obtained from Bornean and Sumatran orang-utans.

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