1887

Abstract

To investigate the evolutionary dynamics of rabies virus (RABV) in China, we collected and sequenced 55 isolates sampled from 14 Chinese provinces over the last 40 years and performed a coalescent-based analysis of the G gene. This revealed that the RABV currently circulating in China is composed of three main groups. Bayesian coalescent analysis estimated the date of the most recent common ancestor for the current RABV Chinese strains to be 1412 (with a 95 % confidence interval of 1006–1736). The estimated mean substitution rate for the G gene sequences (3.961×10 substitutions per site per year) was in accordance with previous reports for RABV.

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2010-03-01
2019-11-21
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References

  1. Badrane, H., Bahloul, C., Perrin, P. & Tordo, N. ( 2001; ). Evidence of two Lyssavirus phylogroups with distinct pathogenicity and immunogenicity. J Virol 75, 3268–3276.[CrossRef]
    [Google Scholar]
  2. Bai, X. H., Gu, L., Cynthia, K., Warner, C. K. & Makonnen, F. ( 1994; ). Sequencing and analysis of nucleotides of the glycoprotein of Chinese street strain (CGX89–1) of rabies virus. Zhonghua Min Guo Wei Sheng Wu Ji Mian Yi Xue Za Zhi 14, 10–15 (in Chinese).
    [Google Scholar]
  3. Bourhy, H., Reynes, J. M., Dunham, E. J., Dacheux, L., Larrous, F., Huong, V. T., Xu, G., Yan, J., Miranda, M. E. & Holmes, E. C. ( 2008; ). The origin and phylogeography of dog rabies virus. J Gen Virol 89, 2673–2681.[CrossRef]
    [Google Scholar]
  4. Davis, P. L., Holmes, E. C., Larrous, F., Van Poel, W., Tjornehoj, K., Alonso, W. J. & Bourhy, H. ( 2005; ). Phylogeography, population dynamics, and molecular evolution of European bat lyssaviruses. J Virol 79, 10487–10497.[CrossRef]
    [Google Scholar]
  5. Davis, P. L., Bourhy, H. & Holmes, E. C. ( 2006; ). The evolutionary history and dynamics of bat rabies virus. Infect Genet Evol 6, 464–473.[CrossRef]
    [Google Scholar]
  6. Drummond, A. J., Nicholls, G. K., Rodrigo, A. G. & Solomon, W. ( 2002; ). Estimating mutation parameters, population history and genealogy simultaneously from temporally spaced sequence data. Genetics 161, 1307–1320.
    [Google Scholar]
  7. Drummond, A., Pybus, O. G. & Rambaut, A. ( 2003; ). Inference of viral evolutionary rates from molecular sequences. Adv Parasitol 54, 331–358.
    [Google Scholar]
  8. Drummond, A. J., Ho, S. Y. W., Phillips, M. J. & Rambaut, A. ( 2006; ). Relaxed phylogenetics and dating with confidence. PLoS Biol 4, e88 [CrossRef]
    [Google Scholar]
  9. Fèvre, E. M., Bronsvoort, B. M., Hamilton, K. A. & Cleaveland, S. ( 2006; ). Animal movements and the spread of infectious diseases. Trends Microbiol 14, 125–131.[CrossRef]
    [Google Scholar]
  10. Hampson, K., Dushoff, J., Bingham, J., Bruckner, G., Ali, Y. H. & Dobson, A. ( 2007; ). Synchronous cycles of domestic dog rabies in sub-Saharan Africa and the impact of control efforts. Proc Natl Acad Sci U S A 104, 7717–7722.[CrossRef]
    [Google Scholar]
  11. Holmes, E. C., Woelk, C. H., Kassis, R. & Bourhy, H. ( 2002; ). Genetic constraints and the adaptive evolution of rabies virus in nature. Virology 292, 247–257.[CrossRef]
    [Google Scholar]
  12. Hughes, G. J., Páez, A., Boshell, J. & Rupprecht, C. E. ( 2004; ). A phylogenetic reconstruction of the epidemiological history of canine rabies virus variants in Colombia. Infect Genet Evol 4, 45–51.[CrossRef]
    [Google Scholar]
  13. Hughes, G. J., Orciari, L. A. & Rupprecht, C. E. ( 2005; ). Evolutionary timescale of rabies virus adaptation to North American bats inferred from the substitution rate of the nucleoprotein gene. J Gen Virol 86, 1467–1474.[CrossRef]
    [Google Scholar]
  14. Ito, N., Kakemizu, M., Ito, K. A., Yamamoto, A., Yoshida, Y., Sugiyama, M. & Minamoto, N. ( 2001; ). A comparison of complete genome sequences of the attenuated RC-HL strain of rabies virus used for production of animal vaccine in Japan, and the parental Nishigahara strain. Microbiol Immunol 45, 51–58.[CrossRef]
    [Google Scholar]
  15. Jenkins, S. R. & Winkler, W. G. ( 1987; ). Descriptive epidemiology from an epizootic of raccoon rabies in the Middle Atlantic States, 1982–1983. Am J Epidemiol 126, 429–437.
    [Google Scholar]
  16. Liu, Q., Xiong, Y., Luo, T. R., Wei, Y. C., Nan, S. J., Liu, F., Pan, Y., Feng, L., Zhu, W. & other authors ( 2007; ). Molecular epidemiology of rabies in Guangxi Province, south of China. J Clin Virol 39, 295–303.[CrossRef]
    [Google Scholar]
  17. Ming, P. G., Du, J. L., Tang, Q., Yan, J. X., Nadin-Davis, S. A., Li, H., Tao, X. Y., Huang, Y., Hu, R. L. & Liang, G. D. ( 2009; ). Molecular characterization of the complete genome of a street rabies virus isolated in China. Virus Res 143, 6–14.[CrossRef]
    [Google Scholar]
  18. Meng, S. L., Yan, J. X., Xu, G. L., Nadin-Davis, S. A., Ming, P. G., Liu, S. Y., Ming, H. T., Zhu, F. C., Zhou, D. J. & other authors ( 2007; ). A molecular epidemiological study targeting the glycoprotein gene of rabies virus isolates from China. Virus Res 124, 125–138.[CrossRef]
    [Google Scholar]
  19. Posada, D. & Crandall, K. A. ( 1998; ). modeltest: testing the model of DNA substitution. Bioinformatics 14, 817–818.[CrossRef]
    [Google Scholar]
  20. Suchard, M. A., Weiss, R. E. & Sinsheimer, J. S. ( 2001; ). Bayesian selection of continuous-time Markov chain evolutionary models. Mol Biol Evol 18, 1001–1013.[CrossRef]
    [Google Scholar]
  21. Talbi, C., Holmes, E. C., de Benedictis, P., Faye, O., Nakoune, E., Gamatie, D., Diarra, A., Elmamy, B. O., Sow, A., Adjogoua, E. V., Sangare, O., Dundon, W. G., Capua, I., Sall, A. A. & Bourhy, H. ( 2009; ). Evolutionary history and dynamics of dog rabies virus in western and central Africa. J Gen Virol 90, 783–791.[CrossRef]
    [Google Scholar]
  22. Tang, Q. & Li, H. ( 2005; ). Epidemic situation and related factors analysis of rabies in China. Zhonghua Liu Xing Bing Xue Za Zhi 26, 223–224 (in Chinese).
    [Google Scholar]
  23. Tang, Q., Orciari, L. A., Rupprechti, C. E. & Zhao, X. ( 2000; ). Sequencing and positional analysis of the glycoprotein gene of four Chinese rabies viruses. Zhongguo Bingduxue 15, 22–33 (in Chinese).
    [Google Scholar]
  24. Wang, X. J. & Huang, J. T. ( 2001; ). Epidemiology. In Rabies and Rabies Vaccines, 1st edn, pp. 127–144. Edited by Y. X. Yu. Beijing, China: Chinese Medicine Technology Press.
  25. WHO ( 2005; ). Expert Consultation on Rabies, First Report. WHO Technical Report Series, No 931. Geneva: World Health Organization.
  26. Windiyaningsih, C., Wilde, H., Meslin, F. X., Suroso, T. & Widarso, H. S. ( 2004; ). The rabies epidemic on Flores Islands, Indonesia (1998–2003). J Med Assoc Thai 87, 1389–1393.
    [Google Scholar]
  27. Zhang, Y. Z., Xiong, C. L., Xiao, D. L., Jiang, R. J., Wang, Z. X., Zhang, L. Z. & Fu, Z. F. ( 2005; ). Human rabies in China. Emerg Infect Dis 11, 1983–1984.[CrossRef]
    [Google Scholar]
  28. Zhang, Y. Z., Xiong, C. L., Zou, Y., Wang, D. M., Jiang, R. J., Xiao, Q. Y., Hao, Z. Y., Zhang, L. Z., Yu, Y. X. & Fu, Z. F. ( 2006; ). Molecular characterization of rabies virus isolates in China during 2004. Virus Res 121, 179–188.[CrossRef]
    [Google Scholar]
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