@article{mbs:/content/journal/jgv/10.1099/vir.0.014555-0, author = "Lewsey, Mathew G. and Carr, John P.", title = "Effects of DICER-like proteins 2, 3 and 4 on cucumber mosaic virus and tobacco mosaic virus infections in salicylic acid-treated plants", journal= "Journal of General Virology", year = "2009", volume = "90", number = "12", pages = "3010-3014", doi = "https://doi.org/10.1099/vir.0.014555-0", url = "https://www.microbiologyresearch.org/content/journal/jgv/10.1099/vir.0.014555-0", publisher = "Microbiology Society", issn = "1465-2099", type = "Journal Article", abstract = "Salicylic acid (SA)-mediated resistance and RNA silencing are both important plant antiviral defence mechanisms. To investigate overlap between these resistance phenomena, we examined the ability of mutant Arabidopsis thaliana plants lacking DICER-like (DCL) endoribonucleases 2, 3 and 4 to exhibit SA-induced defence. We found that in dcl2/3/4 triple mutant plants, treatment with exogenous SA stimulated resistance to two positive-sense RNA viruses: cucumber mosaic virus and tobacco mosaic virus. We conclude that DCLs 2, 3 and 4, which are the predominant DCL endoribonucleases involved in silencing of positive-sense RNA viruses, are not required for effective SA-induced resistance to these viruses. However, the findings do not exclude RNA silencing from making a contribution to SA-mediated resistance in wild-type plants.", }