1887

Abstract

Solar UV radiation is the main risk factor for cutaneous squamous cell carcinoma (SCC), but infections with skin human papillomavirus (HPV) types have also been linked to the development of SCC. Little is known about the natural history of these infections and whether the seroprevalence of skin HPV types is affected by ambient or individual levels of sun exposure. This study investigated this by analysing sera for antibodies to 26 skin HPV types from five phylogenetic genera obtained from 807 healthy individuals from the Netherlands, Italy and Australia, countries with strong differences in sunlight intensity. Overall HPV seroprevalence was similar across the three countries (50–57 % for -HPV types, 40–48 % for -HPV types), and the most frequent -HPV and -HPV types were the same in all countries. The highest seroprevalences for 24 of the 26 skin HPV types were observed in Italy (14 types) and Australia (ten types). Seroprevalence among men was generally higher than among women, and the male sex was significantly associated with both -HPV [odds ratio (OR) 2.81, 95 % confidence interval (CI) 1.64–4.82] and -HPV (OR 2.42, 95 % CI 1.40–4.18) antibodies in Australia. The only measure of sun sensitivity or UV exposure significantly associated with skin HPV seroprevalence was found for weekend sun exposure in Australia and -HPV antibodies. It was concluded that type spectra and HPV seroprevalence are similar in countries with different sunlight intensity, and that levels of UV exposure do not play a strong role in the development of skin HPV antibodies in this study population.

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2009-08-01
2019-11-12
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References

  1. Akgul, B., Cooke, J. C. & Storey, A. ( 2006; ). HPV-associated skin disease. J Pathol 208, 165–175.[CrossRef]
    [Google Scholar]
  2. Andersson, K., Waterboer, T., Kirnbauer, R., Slupetzky, K., Iftner, T., de Villiers, E. M., Forslund, O., Pawlita, M. & Dillner, J. ( 2008; ). Seroreactivity to cutaneous human papillomaviruses among patients with nonmelanoma skin cancer or benign skin lesions. Cancer Epidemiol Biomarkers Prev 17, 189–195.[CrossRef]
    [Google Scholar]
  3. Antonsson, A., Karanfilovska, S., Lindqvist, P. G. & Hansson, B. G. ( 2003; ). General acquisition of human papillomavirus infections of skin occurs in early infancy. J Clin Microbiol 41, 2509–2514.[CrossRef]
    [Google Scholar]
  4. Berkhout, R. J., Bouwes Bavinck, J. N. & ter Schegget, J. ( 2000; ). Persistence of human papillomavirus DNA in benign and (pre)malignant skin lesions from renal transplant recipients. J Clin Microbiol 38, 2087–2096.
    [Google Scholar]
  5. Bouwes Bavinck, J. N., Euvrard, S., Naldi, L., Nindl, I., Proby, C. M., Neale, R., Abeni, D., Tessari, G. P., Feltkamp, M. C. & other authors ( 2007; ). Keratotic skin lesions and other risk factors are associated with skin cancer in organ-transplant recipients: a case–control study in The Netherlands, United Kingdom, Germany, France, and Italy. J Invest Dermatol 127, 1647–1656.
    [Google Scholar]
  6. Casabonne, D., Michael, K. M., Waterboer, T., Pawlita, M., Forslund, O., Burk, R. D., Travis, R. C., Key, T. J. & Newton, R. ( 2007; ). A prospective pilot study of antibodies against human papillomaviruses and cutaneous squamous cell carcinoma nested in the Oxford component of the European Prospective Investigation into Cancer and Nutrition. Int J Cancer 121, 1862–1868.[CrossRef]
    [Google Scholar]
  7. De Hertog, S. A., Wensveen, C. A., Bastiaens, M. T., Kielich, C. J., Berkhout, M. J., Westendorp, R. G., Vermeer, B. J. & Bouwes Bavinck, J. N. ( 2001; ). Relation between smoking and skin cancer. J Clin Oncol 19, 231–238.
    [Google Scholar]
  8. de Jong-Tieben, L. M., Berkhout, R. J., Smits, H. L., Bouwes Bavinck, J. N., Vermeer, B. J., van der Woude, F. J. & ter Schegget, J. ( 1995; ). High frequency of detection of epidermodysplasia verruciformis-associated human papillomavirus DNA in biopsies from malignant and premalignant skin lesions from renal transplant recipients. J Invest Dermatol 105, 367–371.[CrossRef]
    [Google Scholar]
  9. de Koning, M. N., Struijk, L., Bavinck, J. N., Kleter, B., ter Schegget, J., Quint, W. G. & Feltkamp, M. C. ( 2007; ). Betapapillomaviruses frequently persist in the skin of healthy individuals. J Gen Virol 88, 1489–1495.[CrossRef]
    [Google Scholar]
  10. Dell'Oste, V., Azzimonti, B., De Andrea, M., Mondini, M., Zavattaro, E., Leigheb, G., Weissenborn, S. J., Pfister, H., Michael, K. M. & other authors ( 2008; ). High β-HPV DNA loads and strong seroreactivity are present in epidermodysplasia verruciformis. J Invest Dermatol 129, 1026–1034.
    [Google Scholar]
  11. de Villiers, E. M., Fauquet, C., Broker, T. R., Bernard, H. U. & zur Hausen, H. ( 2004; ). Classification of papillomaviruses. Virology 324, 17–27.[CrossRef]
    [Google Scholar]
  12. Dillner, J. ( 1999; ). The serological response to papillomaviruses. Semin Cancer Biol 9, 423–430.[CrossRef]
    [Google Scholar]
  13. Favre, M., Orth, G., Majewski, S., Baloul, S., Pura, A. & Jablonska, S. ( 1998; ). Psoriasis: a possible reservoir for human papillomavirus type 5, the virus associated with skin carcinomas of epidermodysplasia verruciformis. J Invest Dermatol 110, 311–317.[CrossRef]
    [Google Scholar]
  14. Feltkamp, M. C., Broer, R., di Summa, F. M., Struijk, L., van der Meijden, E., Verlaan, B. P., Westendorp, R. G., ter Schegget, J., Spaan, W. J. & Bouwes Bavinck, J. N. ( 2003; ). Seroreactivity to epidermodysplasia verruciformis-related human papillomavirus types is associated with nonmelanoma skin cancer. Cancer Res 63, 2695–2700.
    [Google Scholar]
  15. Forslund, O. ( 2007; ). Genetic diversity of cutaneous human papillomaviruses. J Gen Virol 88, 2662–2669.[CrossRef]
    [Google Scholar]
  16. Forslund, O., Iftner, T., Andersson, K., Lindelof, B., Hradil, E., Nordin, P., Stenquist, B., Kirnbauer, R., Dillner, J. & de Villiers, E. M. ( 2007; ). Cutaneous human papillomaviruses found in sun-exposed skin: Beta-papillomavirus species 2 predominates in squamous cell carcinoma. J Infect Dis 196, 876–883.[CrossRef]
    [Google Scholar]
  17. Harwood, C. A., Surentheran, T., McGregor, J. M., Spink, P. J., Leigh, I. M., Breuer, J. & Proby, C. M. ( 2000; ). Human papillomavirus infection and non-melanoma skin cancer in immunosuppressed and immunocompetent individuals. J Med Virol 61, 289–297.[CrossRef]
    [Google Scholar]
  18. Herrero, R., Castellsague, X., Pawlita, M., Lissowska, J., Kee, F., Balaram, P., Rajkumar, T., Sridhar, H., Rose, B. & other authors ( 2003; ). Human papillomavirus and oral cancer: the International Agency for Research on Cancer multicenter study. J Natl Cancer Inst 95, 1772–1783.[CrossRef]
    [Google Scholar]
  19. Jablonska, S., Majewski, S., Obalek, S. & Orth, G. ( 1997; ). Cutaneous warts. Clin Dermatol 15, 309–319.[CrossRef]
    [Google Scholar]
  20. Karagas, M. R., Nelson, H. H., Sehr, P., Waterboer, T., Stukel, T. A., Andrew, A., Green, A. C., Bavinck, J. N., Perry, A. & other authors ( 2006; ). Human papillomavirus infection and incidence of squamous cell and basal cell carcinomas of the skin. J Natl Cancer Inst 98, 389–395.[CrossRef]
    [Google Scholar]
  21. Karagas, M. R., Zens, M. S., Nelson, H. H., Mabuchi, K., Perry, A. E., Stukel, T. A., Mott, L. A., Andrew, A. S., Applebaum, K. M. & Linet, M. ( 2007; ). Measures of cumulative exposure from a standardized sun exposure history questionnaire: a comparison with histologic assessment of solar skin damage. Am J Epidemiol 165, 719–726.[CrossRef]
    [Google Scholar]
  22. Kjaerheim, K., Røe, O. D., Waterboer, T., Sehr, P., Rizk, R., Dai, H. Y., Sandeck, H., Larsson, E., Andersen, A. & other authors ( 2007; ). Absence of SV40 antibodies or DNA fragments in prediagnostic mesothelioma serum samples. Int J Cancer 120, 2459–2465.[CrossRef]
    [Google Scholar]
  23. Michael, K. M., Waterboer, T., Sehr, P., Rother, A., Reidel, U., Boeing, H., Bravo, I. G., Schlehofer, J., Gartner, B. C. & Pawlita, M. ( 2008; ). Seroprevalence of 34 human papillomavirus types in the German general population. PLoS Pathog 4, e1000091 [CrossRef]
    [Google Scholar]
  24. Oberyszyn, T. M. ( 2008; ). Non-melanoma skin cancer: importance of gender, immunosuppressive status and vitamin D. Cancer Lett 261, 127–136.[CrossRef]
    [Google Scholar]
  25. Orth, G. ( 2005; ). Human papillomaviruses associated with epidermodysplasia verruciformis in non-melanoma skin cancers: guilty or innocent? J Invest Dermatol 125, xii–xiii.
    [Google Scholar]
  26. Pfister, H. ( 2003; ). Chapter 8: Human papillomavirus and skin cancer. J Natl Cancer Inst Monogr 52–56.
    [Google Scholar]
  27. Santos Nogueira, A. C. & Joekes, I. ( 2004; ). Hair color changes and protein damage caused by ultraviolet radiation. J Photochem Photobiol B 74, 109–117.[CrossRef]
    [Google Scholar]
  28. Sehr, P., Zumbach, K. & Pawlita, M. ( 2001; ). A generic capture ELISA for recombinant proteins fused to glutathione S-transferase: validation for HPV serology. J Immunol Methods 253, 153–162.[CrossRef]
    [Google Scholar]
  29. Sehr, P., Muller, M., Hopfl, R., Widschwendter, A. & Pawlita, M. ( 2002; ). HPV antibody detection by ELISA with capsid protein L1 fused to glutathione S-transferase. J Virol Methods 106, 61–70.[CrossRef]
    [Google Scholar]
  30. Struijk, L., Bouwes Bavinck, J. N., Wanningen, P., van der Meijden, E., Westendorp, R. G., Ter Schegget, J. & Feltkamp, M. C. ( 2003; ). Presence of human papillomavirus DNA in plucked eyebrow hairs is associated with a history of cutaneous squamous cell carcinoma. J Invest Dermatol 121, 1531–1535.[CrossRef]
    [Google Scholar]
  31. Struijk, L., Hall, L., van der Meijden, E., Wanningen, P., Bavinck, J. N., Neale, R., Green, A. C., Ter Schegget, J. & Feltkamp, M. C. ( 2006; ). Markers of cutaneous human papillomavirus infection in individuals with tumor-free skin, actinic keratoses, and squamous cell carcinoma. Cancer Epidemiol Biomarkers Prev 15, 529–535.[CrossRef]
    [Google Scholar]
  32. Termorshuizen, F., Feltkamp, M. C., Struijk, L., de Gruijl, F. R., Bavinck, J. N. & van Loveren, H. ( 2004; ). Sunlight exposure and (sero)prevalence of epidermodysplasia verruciformis-associated human papillomavirus. J Invest Dermatol 122, 1456–1462.[CrossRef]
    [Google Scholar]
  33. Waterboer, T., Sehr, P., Michael, K. M., Franceschi, S., Nieland, J. D., Joos, T. O., Templin, M. F. & Pawlita, M. ( 2005; ). Multiplex human papillomavirus serology based on in situ-purified glutathione S-transferase fusion proteins. Clin Chem 51, 1845–1853.[CrossRef]
    [Google Scholar]
  34. Waterboer, T., Sehr, P. & Pawlita, M. ( 2006; ). Suppression of non-specific binding in serological Luminex assays. J Immunol Methods 309, 200–204.[CrossRef]
    [Google Scholar]
  35. Waterboer, T., Abeni, D., Sampogna, F., Rother, A., Masini, C., Sehr, P., Michael, K. M. & Pawlita, M. ( 2008; ). Serological association of beta and gamma human papillomaviruses with squamous cell carcinoma of the skin. Br J Dermatol 159, 457–459.[CrossRef]
    [Google Scholar]
  36. Weissenborn, S. J., De Koning, M. N., Wieland, U., Quint, W. G. & Pfister, H. J. ( 2009; ). Intrafamilial transmission and family-specific spectra of cutaneous betapapillomaviruses. J Virol 83, 811–816.[CrossRef]
    [Google Scholar]
  37. zur Hausen, H. ( 2002; ). Papillomaviruses and cancer: from basic studies to clinical application. Nat Rev Cancer 2, 342–350.[CrossRef]
    [Google Scholar]
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