1887

Abstract

Accurate viral genotyping is important. Here I investigate genotypes in hepatitis E virus (HEV) and find that the open reading frame (ORF) structure (the lengths of three ORFs and the overlapping relationships among the ORFs) can be a good criterion for genotyping HEV. An inter-genotype recombinant (GenBank accession no. DQ450072) was revealed by analysing the ORF structure and confirmed by phylogenetic analyses. This discovery of the inter-genotype recombinant indicates that genotyping in HEV should be based on full-length sequences. The Mexican strain which is currently classified as a genotype 2 strain also exhibited the mosaic sequence pattern, although without statistical support.

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2009-06-01
2019-11-12
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Supplements

List of information retrieved from GenBank for all full-length HEV sequences used in this study [PDF](86 KB)

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Results of Parti-on detection of breakpoints in GenBank accession no. DQ450072 [PDF](17 KB)

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of all available HEV sequences [FASTA file](529 KB)

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