1887

Journal of General Virology header logo

Volume 90, Issue 5

Novel anellovirus discovered from a mortality event of captive California sea lions Free

Abstract

A viral metagenomic study was performed to investigate potential viral pathogens associated with a mortality event of three captive California sea lions (). This study identified a novel California sea lion anellovirus (ZcAV), with 35 % amino acid identity in the ORF1 region to feline anelloviruses. The double-stranded replicative form of ZcAV was detected in lung tissue, suggesting that ZcAV replicates in sea lion lungs. Specific PCR revealed the presence of ZcAV in the lung tissue of all three sea lions involved in the mortality event, but not in three other sea lions from the same zoo. In addition, ZcAV was detected at low frequency (11 %) in the lungs of wild sea lions. The higher prevalence of ZcAV and presence of the double-stranded replicative form in the lungs of sea lions from the mortality event suggest that ZcAV was associated with the death of these animals.

  • Received:
  • Accepted:
  • Published Online:
SGM
Loading

Article metrics loading...

/content/journal/jgv/10.1099/vir.0.008987-0
2009-05-01
2024-04-25
Loading full text...

Full text loading...

/deliver/fulltext/jgv/90/5/1256.html?itemId=/content/journal/jgv/10.1099/vir.0.008987-0&mimeType=html&fmt=ahah

References

  1. Allander T., Tammi M. T., Eriksson M., Bjerkner A., Tiveljung-Lindell A., Andersson B. 2005; Cloning of a human parvovirus by molecular screening of respiratory tract samples. Proc Natl Acad Sci U S A 102:12891–12896 [CrossRef]
     [Google Scholar]
  2. Altschul S. F., Gish W., Miller W., Myers E. W., Lipman D. J. 1990; Basic local alignment search tool. J Mol Biol 215:403–410 [CrossRef]
     [Google Scholar]
  3. Altschul S. F., Madden T. L., Schaffer A. A., Zhang J. H., Zhang Z., Miller W., Lipman D. J. 1997; Gapped blast and psi-blast: a new generation of protein database search programs. Nucleic Acids Res 25:3389–3402 [CrossRef]
     [Google Scholar]
  4. Bando M., Ohno S., Oshikawa K., Takahashi M., Okamoto H., Sugiyama Y. 2001; Infection of TT virus in patients with idiopathic pulmonary fibrosis. Respir Med 95:935–942 [CrossRef]
     [Google Scholar]
  5. Biagini P., Todd D., Bendinelli M., Hino S., Mankertz A., Mishiro S., Niel C., Okamoto H., Raidal S. other authors 2005; Genus Anellovirus . In Virus Taxonomy: Eighth Report of the International Committee on Taxonomy of Viruses pp 335–341Edited by Fauquet C. M., Mayo M. A., Maniloff J., Desselberger U., Ball. San Diego: Elsevier Academic Press;
     [Google Scholar]
  6. Biagini P., Uch R., Belhouchet M., Attoui H., Cantaloube J. F., Brisbarre N., de Micco P. 2007; Circular genomes related to anelloviruses identified in human and animal samples by using a combined rolling-circle amplification/sequence-independent single primer amplification approach. J Gen Virol 88:2696–2701 [CrossRef]
     [Google Scholar]
  7. Bigarre L., Beven V., de Boisseson C., Grasland B., Rose N., Biagini P., Jestin A. 2005; Pig anelloviruses are highly prevalent in swine herds in France. J Gen Virol 86:631–635 [CrossRef]
     [Google Scholar]
  8. Breathnach R., Benoist C., O'Hare K., Gannon F., Chambon P. 1978; Ovalbumin gene: evidence for a leader sequence in mRNA and DNA sequences at the exon–intron boundaries. Proc Natl Acad Sci U S A 75:4853–4857 [CrossRef]
     [Google Scholar]
  9. Breitbart M., Rohwer F. 2005; Method for discovering novel DNA viruses in blood using viral particle selection and shotgun sequencing. Biotechniques 39:729–736 [CrossRef]
     [Google Scholar]
  10. Breitbart M., Salamon P., Andresen B., Mahaffy J. M., Segall A. M., Mead D., Azam F., Rohwer F. 2002; Genomic analysis of uncultured marine viral communities. Proc Natl Acad Sci U S A 99:14250–14255 [CrossRef]
     [Google Scholar]
  11. Cleaveland S., Laurenson M. K., Taylor L. H. 2001; Diseases of humans and their domestic mammals: pathogen characteristics, host range and the risk of emergence. Philos Trans R Soc Lond B Biol Sci 356:991–999 [CrossRef]
     [Google Scholar]
  12. Cokol M., Nair R., Rost B. 2000; Finding nuclear localization signals. EMBO Rep 1:411–415 [CrossRef]
     [Google Scholar]
  13. Davidson I., Shulman L. M. 2008; Unraveling the puzzle of human anellovirus infections by comparison with avian infections with the chicken anemia virus. Virus Res 137:1–15 [CrossRef]
     [Google Scholar]
  14. Delwart E. L. 2007; Viral metagenomics. Rev Med Virol 17:115–131 [CrossRef]
     [Google Scholar]
  15. Edwards R. A., Rohwer F. 2005; Viral metagenomics. Nat Rev Microbiol 3:504–510 [CrossRef]
     [Google Scholar]
  16. Flynn J. J., Nedbal M. A. 1998; Phylogeny of the Carnivora (Mammalia): Congruence vs incompatibility among multiple data sets. Mol Phylogenet Evol 9:414–426 [CrossRef]
     [Google Scholar]
  17. Greig D. J., Gulland F. M. D., Kreuder C. 2005; A decade of live California sea lion ( Zalophus californianus ) strandings along the central California coast: causes and trends, 1991–2000. Aquat Mamm 31:11–22 [CrossRef]
     [Google Scholar]
  18. Hall T. A. 1999; BioEdit: a user-friendly biological sequence alignment editor and analysis program for Windows 95/98/NT. Nucleic Acids Symp Ser 41:95–98
     [Google Scholar]
  19. Harvell C. D., Kim K., Burkholder J. M., Colwell R. R., Epstein P. R., Grimes D. J., Hofmann E. E., Lipp E. K., Osterhaus A. D. other authors 1999; Emerging marine diseases – climate links and anthropogenic factors. Science 285:1505–1510 [CrossRef]
     [Google Scholar]
  20. Hino S., Miyata H. 2007; Torque teno virus (TTV): current status. Rev Med Virol 17:45–57 [CrossRef]
     [Google Scholar]
  21. Jones M. S., Kapoor A., Lukashov V. V., Simmonds P., Hecht F., Delwart E. 2005; New DNA viruses identified in patients with acute viral infection syndrome. J Virol 79:8230–8236 [CrossRef]
     [Google Scholar]
  22. Kamahora T., Hino S., Miyata H. 2000; Three spliced mRNAs of TT virus transcribed from a plasmid containing the entire genome in COS1 cells. J Virol 74:9980–9986 [CrossRef]
     [Google Scholar]
  23. Kruse H., Kirkemo A. M., Handeland K. 2004; Wildlife as source of zoonotic infections. Emerg Infect Dis 10:2067–2072 [CrossRef]
     [Google Scholar]
  24. Kuiken T. 2005; Pathogen surveillance in animals. Science 309:1680–1681 [CrossRef]
     [Google Scholar]
  25. Leary T. P., Erker J. C., Chalmers M. L., Desai S. M., Mushahwar I. K. 1999; Improved detection systems for TT virus reveal high prevalence in humans, non-human primates and farm animals. J Gen Virol 80:2115–2120
     [Google Scholar]
  26. Mount S. M. 1982; A catalogue of splice junction sequences. Nucleic Acids Res 10:459–472 [CrossRef]
     [Google Scholar]
  27. Ng T. F. F., Manire C., Borrowman K., Langer T., Ehrhart L., Breitbart M. 2009; Discovery of a novel single-stranded DNA virus from a sea turtle fibropapilloma by using viral metagenomics. J Virol 83:2500–2509 [CrossRef]
     [Google Scholar]
  28. Ninomiya M., Nishizawa T., Takahashi M., Lorenzo F. R., Shimosegawa T., Okamoto H. 2007; Identification and genomic characterization of a novel human torque teno virus of 3.2 kb. J Gen Virol 88:1939–1944 [CrossRef]
     [Google Scholar]
  29. Nishizawa T., Okamoto H., Konishi K., Yoshizawa H., Miyakawa Y., Mayumi M. 1997; A novel DNA virus (TTV) associated with elevated transaminase levels in posttransfusion hepatitis of unknown etiology. Biochem Biophys Res Commun 241:92–97 [CrossRef]
     [Google Scholar]
  30. Noteborn M. H. M., Deboer G. F., Vanroozelaar D. J., Karreman C., Kranenburg O., Vos J. G., Jeurissen S. H. M., Hoeben R. C., Zantema A. other authors 1991; Characterization of cloned chicken anemia virus DNA that contains all elements for the infectious replication cycle. J Virol 65:3131–3139
     [Google Scholar]
  31. Okamoto H., Nishizawa T., Kato N., Ukita M., Ikeda H., Iizuka H., Miyakawa Y., Mayumi M. 1998; Molecular cloning and characterization of a novel DNA virus (TTV) associated with posttransfusion hepatitis of unknown etiology. Hepatol Res 10:1–16 [CrossRef]
     [Google Scholar]
  32. Okamoto H., Takahashi M., Nishizawa T., Tawara A., Sugai Y., Sai T., Tanaka T., Tsuda F. 2000a; Replicative forms of TT virus DNA in bone marrow cells. Biochem Biophys Res Commun 270:657–662 [CrossRef]
     [Google Scholar]
  33. Okamoto H., Ukita M., Nishizawa T., Kishimoto J., Hoshi Y., Mizuo H., Tanaka T., Miyakawa Y., Mayumi M. 2000b; Circular double-stranded forms of TT virus DNA in the liver. J Virol 74:5161–5167 [CrossRef]
     [Google Scholar]
  34. Okamoto H., Nishizawa T., Takahashi M., Asabe S., Tsuda F., Yoshikawa A. 2001a; Heterogeneous distribution of TT virus of distinct genotypes in multiple tissues from infected humans. Virology 288:358–368 [CrossRef]
     [Google Scholar]
  35. Okamoto H., Nishizawa T., Takahashi M., Tawara A., Peng Y. H., Kishimoto J., Wang Y. 2001b; Genomic and evolutionary characterization of TT virus (TTV) in tupaias and comparison with species-specific TTVs in humans and non-human primates. J Gen Virol 82:2041–2050
     [Google Scholar]
  36. Okamoto H., Takahashi M., Nishizawa T., Tawara A., Fukai K., Muramatsu U., Naito Y., Yoshikawa A. 2002; Genomic characterization of TT viruses (TTVs) in pigs, cats and dogs and their relatedness with species-specific TTVs in primates and tupaias. J Gen Virol 83:1291–1297
     [Google Scholar]
  37. Takahashi K., Hijikata M., Samokhvalov E. I., Mishiro S. 2000; Full or near full length nucleotide sequences of TT virus variants (types SANBAN and YONBAN) and the TT virus-like mini virus. Intervirology 43:119–123 [CrossRef]
     [Google Scholar]
  38. Tamura K., Dudley J., Nei M., Kumar S. 2007; mega4: Molecular evolutionary genetics analysis (mega) software version 4.0. Mol Biol Evol 24:1596–1599 [CrossRef]
     [Google Scholar]
  39. Van Bressem M. F., Van Waerebeek K., Raga J. A. 1999; A review of virus infections of cetaceans and the potential impact of morbilliviruses, poxviruses and papillomaviruses on host population dynamics. Dis Aquat Organ 38:53–65 [CrossRef]
     [Google Scholar]
http://instance.metastore.ingenta.com/content/journal/jgv/10.1099/vir.0.008987-0
Loading
Novel anellovirus discovered from a mortality event of captive California sea lions
J. Gen. Virol. 90, 1256 (2009); https://doi.org/10.1099/vir.0.008987-0
/content/journal/jgv/10.1099/vir.0.008987-0
/content/journal/jgv/10.1099/vir.0.008987-0
Loading

Data & Media loading...

Most cited Most Cited RSS feed

This is a required field
Please enter a valid email address
Approval was a Success
Invalid data
An Error Occurred
Approval was partially successful, following selected items could not be processed due to error