@article{mbs:/content/journal/jgv/10.1099/vir.0.007377-0, author = "Wood, Andrew and Webb, Benjamin L. J. and Bartosch, Birke and Schaller, Torsten and Takeuchi, Yasuhiro and Towers, Greg J.", title = "Porcine endogenous retroviruses PERV A and A/C recombinant are insensitive to a range of divergent mammalian TRIM5α proteins including human TRIM5α", journal= "Journal of General Virology", year = "2009", volume = "90", number = "3", pages = "702-709", doi = "https://doi.org/10.1099/vir.0.007377-0", url = "https://www.microbiologyresearch.org/content/journal/jgv/10.1099/vir.0.007377-0", publisher = "Microbiology Society", issn = "1465-2099", type = "Journal Article", abstract = "The potential risk of cross-species transmission of porcine endogenous retroviruses (PERV) to humans has slowed the development of xenotransplantation, using pigs as organ donors. Here, we show that PERVs are insensitive to restriction by divergent TRIM5α molecules despite the fact that they strongly restrict a variety of divergent lentiviruses. We also show that the human PERV A/C recombinant clone 14/220 reverse transcribes with increased efficiency in human cells, leading to significantly higher infectivity. We conclude that xenotransplantation studies should consider the danger of highly infectious TRIM5α-insensitive human-tropic PERV recombinants.", }