%0 Journal Article %A Stow, Nigel D. %A Evans, Vanessa C. %A Matthews, David A. %T Upstream-binding factor is sequestered into herpes simplex virus type 1 replication compartments %D 2009 %J Journal of General Virology, %V 90 %N 1 %P 69-73 %@ 1465-2099 %R https://doi.org/10.1099/vir.0.006353-0 %I Microbiology Society, %X Previous reports have shown that adenovirus recruits nucleolar protein upstream-binding factor (UBF) into adenovirus DNA replication centres. Here, we report that despite having a different mode of viral DNA replication, herpes simplex virus type 1 (HSV-1) also recruits UBF into viral DNA replication centres. Moreover, as with adenovirus, enhanced green fluorescent protein-tagged fusion proteins of UBF inhibit viral DNA replication. We propose that UBF is recruited to the replication compartments to aid replication of HSV-1 DNA. In addition, this is a further example of the role of nucleolar components in viral life cycles. %U https://www.microbiologyresearch.org/content/journal/jgv/10.1099/vir.0.006353-0