@article{mbs:/content/journal/jgv/10.1099/vir.0.006353-0, author = "Stow, Nigel D. and Evans, Vanessa C. and Matthews, David A.", title = "Upstream-binding factor is sequestered into herpes simplex virus type 1 replication compartments", journal= "Journal of General Virology", year = "2009", volume = "90", number = "1", pages = "69-73", doi = "https://doi.org/10.1099/vir.0.006353-0", url = "https://www.microbiologyresearch.org/content/journal/jgv/10.1099/vir.0.006353-0", publisher = "Microbiology Society", issn = "1465-2099", type = "Journal Article", abstract = "Previous reports have shown that adenovirus recruits nucleolar protein upstream-binding factor (UBF) into adenovirus DNA replication centres. Here, we report that despite having a different mode of viral DNA replication, herpes simplex virus type 1 (HSV-1) also recruits UBF into viral DNA replication centres. Moreover, as with adenovirus, enhanced green fluorescent protein-tagged fusion proteins of UBF inhibit viral DNA replication. We propose that UBF is recruited to the replication compartments to aid replication of HSV-1 DNA. In addition, this is a further example of the role of nucleolar components in viral life cycles.", }