@article{mbs:/content/journal/jgv/10.1099/vir.0.006239-0, author = "Hensler, Heather R. and Rappocciolo, Giovanna and Rinaldo, Charles R. and Jenkins, Frank J.", title = "Cytokine production by human herpesvirus 8-infected dendritic cells", journal= "Journal of General Virology", year = "2009", volume = "90", number = "1", pages = "79-83", doi = "https://doi.org/10.1099/vir.0.006239-0", url = "https://www.microbiologyresearch.org/content/journal/jgv/10.1099/vir.0.006239-0", publisher = "Microbiology Society", issn = "1465-2099", type = "Journal Article", abstract = "We have shown previously that human herpesvirus 8 (HHV-8)-infected dendritic cells (DCs) undergo incomplete maturation and have a defective antigen-presenting function. Here, we examined the effects of HHV-8 infection on cytokine production, which is critical to the function of DCs. We detected expression of interleukin (IL)-6, tumour necrosis factor (TNF)-α, macrophage inflammatory protein (MIP)-1α, MIP-1β, RANTES and IL-12p40 from 2 to 6 h post-infection, and these peaked by 15–24 h. Expression of these factors decreased 24–48 h post-infection, with the exception of TNF-α which remained high throughout the entire 72 h. Interestingly, while IL-12p40 expression increased post-infection, bioactive IL-12p70 was not detected in the supernatants. These results suggest an intentional skewing of cytokine production in HHV-8-infected DCs towards induction of a Th2 response.", }