1887

Abstract

The neonatal Fc receptor (FcRn) is the only receptor known to be able to transport IgG across cell barriers and may therefore modulate virus infection. FcRn is expressed efficiently in hepatocytes. We therefore investigated the possible involvement of an FcRn-dependent mechanism in hepatitis C virus (HCV) neutralization. Our study, in both HCV pseudoparticles and HCV in cell-culture models, showed that FcRn was not involved in the intracellular neutralization of HCV, in contrast to the situation observed for influenza A virus.

Loading

Article metrics loading...

/content/journal/jgv/10.1099/vir.0.000060
2015-05-01
2022-01-27
Loading full text...

Full text loading...

/deliver/fulltext/jgv/96/5/1062.html?itemId=/content/journal/jgv/10.1099/vir.0.000060&mimeType=html&fmt=ahah

References

  1. Akilesh S., Christianson G. J., Roopenian D. C., Shaw A. S. 2007; Neonatal FcR expression in bone marrow-derived cells functions to protect serum IgG from catabolism. J Immunol 179:4580–4588 [View Article][PubMed]
    [Google Scholar]
  2. Bai Y., Ye L., Tesar D. B., Song H., Zhao D., Björkman P. J., Roopenian D. C., Zhu X. 2011; Intracellular neutralization of viral infection in polarized epithelial cells by neonatal Fc receptor (FcRn)-mediated IgG transport. Proc Natl Acad Sci U S A 108:18406–18411 [View Article][PubMed]
    [Google Scholar]
  3. Bartosch B., Dubuisson J., Cosset F.-L. 2003; Infectious hepatitis C virus pseudo-particles containing functional E1–E2 envelope protein complexes. J Exp Med 197:633–642 [View Article][PubMed]
    [Google Scholar]
  4. Dorner M., Horwitz J. A., Robbins J. B., Barry W. T., Feng Q., Mu K., Jones C. T., Schoggins J. W., Catanese M. T. et al. 2011; A genetically humanized mouse model for hepatitis C virus infection. Nature 474:208–211 [View Article][PubMed]
    [Google Scholar]
  5. Giang E., Dorner M., Prentoe J. C., Dreux M., Evans M. J., Bukh J., Rice C. M., Ploss A., Burton D. R., Law M. 2012; Human broadly neutralizing antibodies to the envelope glycoprotein complex of hepatitis C virus. Proc Natl Acad Sci U S A 109:6205–6210 [View Article][PubMed]
    [Google Scholar]
  6. Lavillette D., Morice Y., Germanidis G., Donot P., Soulier A., Pagkalos E., Sakellariou G., Intrator L., Bartosch B. et al. 2005; Human serum facilitates hepatitis C virus infection, and neutralizing responses inversely correlate with viral replication kinetics at the acute phase of hepatitis C virus infection. J Virol 79:6023–6034 [View Article][PubMed]
    [Google Scholar]
  7. Law M., Maruyama T., Lewis J., Giang E., Tarr A. W., Stamataki Z., Gastaminza P., Chisari F. V., Jones I. M. et al. 2008; Broadly neutralizing antibodies protect against hepatitis C virus quasispecies challenge. Nat Med 14:25–27 [View Article][PubMed]
    [Google Scholar]
  8. Lohmann V., Bartenschlager R. 2014; On the history of hepatitis C virus cell culture systems. J Med Chem 57:1627–1642 [View Article][PubMed]
    [Google Scholar]
  9. Pestka J. M., Zeisel M. B., Bläser E., Schürmann P., Bartosch B., Cosset F.-L., Patel A. H., Meisel H., Baumert J. et al. 2007; Rapid induction of virus-neutralizing antibodies and viral clearance in a single-source outbreak of hepatitis C. Proc Natl Acad Sci U S A 104:6025–6030 [View Article][PubMed]
    [Google Scholar]
  10. Raghavan M., Bonagura V. R., Morrison S. L., Bjorkman P. J. 1995; Analysis of the pH dependence of the neonatal Fc receptor/immunoglobulin G interaction using antibody and receptor variants. Biochemistry 34:14649–14657 [View Article][PubMed]
    [Google Scholar]
  11. Roopenian D. C., Akilesh S. 2007; FcRn: the neonatal Fc receptor comes of age. Nat Rev Immunol 7:715–725 [View Article][PubMed]
    [Google Scholar]
  12. Sabo M. C., Luca V. C., Prentoe J., Hopcraft S. E., Blight K. J., Yi M., Lemon S. M., Ball J. K., Bukh J. et al. 2011; Neutralizing monoclonal antibodies against hepatitis C virus E2 protein bind discontinuous epitopes and inhibit infection at a postattachment step. J Virol 85:7005–7019 [View Article][PubMed]
    [Google Scholar]
  13. Sautto G. A., Diotti R. A., Clementi M. 2012; New therapeutic options for HCV infection in the monoclonal antibody era. New Microbiol 35:387–397[PubMed]
    [Google Scholar]
  14. Schilling R., Ijaz S., Davidoff M., Lee J. Y., Locarnini S., Williams R., Naoumov N. V. 2003; Endocytosis of hepatitis B immune globulin into hepatocytes inhibits the secretion of hepatitis B virus surface antigen and virions. J Virol 77:8882–8892 [View Article][PubMed]
    [Google Scholar]
  15. Tesar D. B., Tiangco N. E., Bjorkman P. J. 2006; Ligand valency affects transcytosis, recycling and intracellular trafficking mediated by the neonatal Fc receptor. Traffic 7:1127–1142 [View Article][PubMed]
    [Google Scholar]
  16. Zhu X., Meng G., Dickinson B. L., Li X., Mizoguchi E., Miao L., Wang Y., Robert C., Wu B. et al. 2001; MHC class I-related neonatal Fc receptor for IgG is functionally expressed in monocytes, intestinal macrophages, and dendritic cells. J Immunol 166:3266–3276 [View Article][PubMed]
    [Google Scholar]
http://instance.metastore.ingenta.com/content/journal/jgv/10.1099/vir.0.000060
Loading
/content/journal/jgv/10.1099/vir.0.000060
Loading

Data & Media loading...

Supplements

Supplementary Data

PDF

Most cited this month Most Cited RSS feed

This is a required field
Please enter a valid email address
Approval was a Success
Invalid data
An Error Occurred
Approval was partially successful, following selected items could not be processed due to error