@article{mbs:/content/journal/jgv/10.1099/vir.0.000055, author = "Medici, Maria Cristina and Tummolo, Fabio and Bonica, Melisa Berenice and Heylen, Elisabeth and Zeller, Mark and Calderaro, Adriana and Matthijnssens, Jelle", title = "Genetic diversity in three bovine-like human G8P[14] and G10P[14] rotaviruses suggests independent interspecies transmission events", journal= "Journal of General Virology", year = "2015", volume = "96", number = "5", pages = "1161-1168", doi = "https://doi.org/10.1099/vir.0.000055", url = "https://www.microbiologyresearch.org/content/journal/jgv/10.1099/vir.0.000055", publisher = "Microbiology Society", issn = "1465-2099", type = "Journal Article", abstract = "The group A rotavirus (RVA) P[14] genotype has been detected sporadically in humans and is thought to be acquired through zoonotic transmission. The present study describes the full-length genome analysis of two G8P[14] and one G10P[14] human RVAs detected in Italy. The strains possessed the typical bovine-like I2-R2-C2-M2-A3/A11-N2-T6-E2-H3 genotype constellation. All the segments of the two G8P[14] RVAs were most closely related to bovine(-like) strains but were relatively distant to each other, suggesting two independent interspecies transmission events. Likewise, the G10P[14] RVA gene segments were most similar to bovine(-like) RVAs but distinct from the G8 strains. The history of these strains probably involved the interspecies transmission of these viruses to humans from an as-yet-unidentified animal host, without evidence of reassortment events involving human RVAs. These results reinforce the potential of animal viruses to cross the host-species barrier, causing disease and increased viral genetic diversity in humans.", }