RT Journal Article SR Electronic(1) A1 Patrono, Livia V. A1 Bonfante, Francesco A1 Zanardello, Claudia A1 Terregino, Calogero A1 Capua, Ilaria A1 Murcia, Pablo R.YR 2015 T1 Phylogenetically distinct equine influenza viruses show different tropism for the swine respiratory tract JF Journal of General Virology, VO 96 IS 5 SP 969 OP 974 DO https://doi.org/10.1099/vir.0.000049 PB Microbiology Society, SN 1465-2099, AB Influenza A viruses circulate in a wide range of animals. H3N8 equine influenza virus (EIV) is an avian-origin virus that has established in dogs as canine influenza virus (CIV) and has also been isolated from camels and pigs. Previous work suggests that mutations acquired during EIV evolution might have played a role in CIV emergence. Given the potential role of pigs as a source of human infections, we determined the ability of H3N8 EIVs to replicate in pig cell lines and in respiratory explants. We show that phylogenetically distinct EIVs display different infection phenotypes along the pig respiratory tract, but not in cell lines. Our results suggest that EIV displays a dynamic host range along its evolutionary history, supporting the view that evolutionary processes play important roles in host range and tropism and also underscoring the utility of using explant cultures to study influenza pathogenesis., UL https://www.microbiologyresearch.org/content/journal/jgv/10.1099/vir.0.000049