1887

Abstract

Various herpesviruses have been discovered in marine mammals and are associated with a wide spectrum of disease. In the present study we describe the detection and phylogenetic analysis of a novel gammaherpesvirus, tentatively called phocine herpesvirus 7 (PhHV-7), which was detected in samples collected during an outbreak of ulcerative gingivitis and glossitis from juvenile harbour seals () at the Seal Rehabilitation and Research Centre, the Netherlands. The presence of this novel gammaherpesvirus was confirmed by viral metagenomics, while no other viruses other than four novel anelloviruses were detected. However, PhHV-7 DNA was also detected in harbour and grey seals () without gingivitis or glossitis. Genetic analysis of the partial polymerase gene of PhHV-7 detected in both species revealed limited sequence variation. Additional studies are needed to elucidate whether the viruses discovered played a role in the disease observed.

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2015-05-01
2019-09-22
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References

  1. Ackermann M.. ( 2006; ). Pathogenesis of gammaherpesvirus infections. . Vet Microbiol 113:, 211–222. [CrossRef] [PubMed]
    [Google Scholar]
  2. Bodewes R., Rubio García A., Wiersma L. C., Getu S., Beukers M., Schapendonk C. M., van Run P. R., van de Bildt M. W., Poen M. J. et al. ( 2013; a). Novel B19-like parvovirus in the brain of a harbor seal. . PLoS ONE 8:, e79259. [CrossRef] [PubMed]
    [Google Scholar]
  3. Bodewes R., van de Bildt M. W., Schapendonk C. M., van Leeuwen M., van Boheemen S., de Jong A. A., Osterhaus A. D., Smits S. L., Kuiken T.. ( 2013; b). Identification and characterization of a novel adenovirus in the cloacal bursa of gulls. . Virology 440:, 84–88. [CrossRef] [PubMed]
    [Google Scholar]
  4. Bodewes R., Hapsari R., Rubio García A., Sánchez Contreras G. J., van de Bildt M. W., de Graaf M., Kuiken T., Osterhaus A. D.. ( 2014; ). Molecular epidemiology of seal parvovirus, 1988-2014. . PLoS ONE 9:, e112129. [CrossRef] [PubMed]
    [Google Scholar]
  5. Darriba D., Taboada G. L., Doallo R., Posada D.. ( 2011; ). ProtTest 3: fast selection of best-fit models of protein evolution. . Bioinformatics 27:, 1164–1165. [CrossRef] [PubMed]
    [Google Scholar]
  6. Darriba D., Taboada G. L., Doallo R., Posada D.. ( 2012; ). jModelTest 2: more models, new heuristics and parallel computing. . Nat Methods 9:, 772. [CrossRef] [PubMed]
    [Google Scholar]
  7. Di Alberti L., Porter S. R., Speight P. M., Scully C. M., Zakrzewska J. M., Williams I. G., Artese L., Piattelli A., Ngui S. L., Teo C. G.. ( 1997; ). Detection of human herpesvirus-8 DNA in oral ulcer tissues of HIV-infected individuals. . Oral Dis 3: (Suppl 1), S133–S134. [CrossRef] [PubMed]
    [Google Scholar]
  8. Gagnon C. A., Tremblay J., Larochelle D., Music N., Tremblay D.. ( 2011; ). Identification of a novel herpesvirus associated with cutaneous ulcers in a fisher (Martes pennanti). . J Vet Diagn Invest 23:, 986–990. [CrossRef] [PubMed]
    [Google Scholar]
  9. Goldstein T., Gulland F., Braun R., Antonelis G., Kashinsky L., Rowles T., Mazet J., Dalton L., Aldridge B., Stott J.. ( 2006; a). Molecular identification of a novel gammaherpesvirus in the endangered Hawaiian monk seal (Monachus schauinslandi). . Mar Mamm Sci 22:, 465–471. [CrossRef]
    [Google Scholar]
  10. Goldstein T., Lowenstine L. J., Lipscomb T. P., Mazet J. A., Novak J., Stott J. L., Gulland F. M.. ( 2006; b). Infection with a novel gammaherpesvirus in northern elephant seals (Mirounga angustirostris). . J Wildl Dis 42:, 830–835. [CrossRef] [PubMed]
    [Google Scholar]
  11. Harder T. C., Harder M., Vos H., Kulonen K., Kennedy-Stoskopf S., Liess B., Appel M. J., Osterhaus A. D.. ( 1996; ). Characterization of phocid herpesvirus-1 and -2 as putative alpha- and gammaherpesviruses of North American and European pinnipeds. . J Gen Virol 77:, 27–35. [CrossRef] [PubMed]
    [Google Scholar]
  12. Hille J. J., Webster-Cyriaque J., Palefski J. M., Raab-Traub N.. ( 2002; ). Mechanisms of expression of HHV8, EBV and HPV in selected HIV-associated oral lesions. . Oral Dis 8: (Suppl 2), 161–168. [CrossRef] [PubMed]
    [Google Scholar]
  13. Hino S., Miyata H.. ( 2007; ). Torque teno virus (TTV): current status. . Rev Med Virol 17:, 45–57. [CrossRef] [PubMed]
    [Google Scholar]
  14. International Committee on Taxonomy of Viruses (ICTV) (2013). Virus Taxonomy: 2013 Release, Available at: (http://www.ictvonline.org/virusTaxonomy.asp).
  15. Katoh K., Standley D. M.. ( 2013; ). MAFFT multiple sequence alignment software version 7: improvements in performance and usability. . Mol Biol Evol 30:, 772–780. [CrossRef] [PubMed]
    [Google Scholar]
  16. Kuiken T., Das Neves C. G.. ( 2012; ). Herpesvirus infections in aquatic mammals. . In Infectious Diseaes of Wild Mammals and Birds in Europe, pp. 18–20. Edited by Gavier-Widen D., Duff J. P., Meredith A... West-Sussex, United Kingdom:: Wiley-Blackwell Ltd;.
    [Google Scholar]
  17. Lebich M., Harder T. C., Frey H. R., Visser I. K., Osterhaus A. D., Liess B.. ( 1994; ). Comparative immunological characterization of type-specific and conserved B-cell epitopes of pinniped, felid and canid herpesviruses. . Arch Virol 136:, 335–347. [CrossRef] [PubMed]
    [Google Scholar]
  18. Maness H. T., Nollens H. H., Jensen E. D., Goldstein T., LaMere S., Childress A., Sykes J., St Leger J., Lacave G. et al. ( 2011; ). Phylogenetic analysis of marine mammal herpesviruses. . Vet Microbiol 149:, 23–29. [CrossRef] [PubMed]
    [Google Scholar]
  19. Martina B. E., Jensen T. H., van de Bildt M. W., Osterhaus A. D., Harder T. C.. ( 2002; ). Variations in the severity of phocid herpesvirus type 1 infections with age in grey seals and harbour seals. . Vet Rec 150:, 572–575. [CrossRef] [PubMed]
    [Google Scholar]
  20. Martina B. E., Verjans G. M. G. M., Kuiken T., van Amerongen G., Osterhaus A. D. M. E.. ( 2007; ). In vitro and in vivo replication of seal gammaherpesviruses in cells of multiple species. . Microbes Infect 9:, 40–46. [CrossRef] [PubMed]
    [Google Scholar]
  21. Ng T. F., Wheeler E., Greig D., Waltzek T. B., Gulland F., Breitbart M.. ( 2011; ). Metagenomic identification of a novel anellovirus in Pacific harbor seal (Phoca vitulina richardsii) lung samples and its detection in samples from multiple years. . J Gen Virol 92:, 1318–1323. [CrossRef] [PubMed]
    [Google Scholar]
  22. Osterhaus A. D., Yang H., Spijkers H. E., Groen J., Teppema J. S., van Steenis G.. ( 1985; ). The isolation and partial characterization of a highly pathogenic herpesvirus from the harbor seal (Phoca vitulina). . Arch Virol 86:, 239–251. [CrossRef] [PubMed]
    [Google Scholar]
  23. Pellett P. E., Davison A. J., Eberle R., Ehlers B., Hayward G. S., Lacoste V., Minson A. C., Nicholas J., Roizman B. et al. ( 2012; ). Order Herpesvirales. . In Virus Taxonomy; Ninth Report of the International Committee on Taxonomy of Viruses, p. 105. Edited by King A. M. Q., Adams M. J., Carstens E. B., Lefkowitz E. J... San Diego:: Academic Press;.
    [Google Scholar]
  24. Schürch A. C., Schipper D., Bijl M. A., Dau J., Beckmen K. B., Schapendonk C. M., Raj V. S., Osterhaus A. D., Haagmans B. L. et al. ( 2014; ). Metagenomic survey for viruses in Western Arctic caribou, Alaska, through iterative assembly of taxonomic units. . PLoS ONE 9:, e105227. [CrossRef] [PubMed]
    [Google Scholar]
  25. Sievers F., Wilm A., Dineen D., Gibson T. J., Karplus K., Li W., Lopez R., McWilliam H., Remmert M. et al. ( 2011; ). Fast, scalable generation of high-quality protein multiple sequence alignments using Clustal Omega. . Mol Syst Biol 7:, 539. [CrossRef] [PubMed]
    [Google Scholar]
  26. Smith J. A., Wellehan J. F. Jr, Pogranichniy R. M., Childress A. L., Landolfi J. A., Terio K. A.. ( 2008; ). Identification and isolation of a novel herpesvirus in a captive mob of eastern grey kangaroos (Macropus giganteus). . Vet Microbiol 129:, 236–245. [CrossRef] [PubMed]
    [Google Scholar]
  27. Smolarek Benson K. A., Manire C. A., Ewing R. Y., Saliki J. T., Townsend F. I., Ehlers B., Romero C. H.. ( 2006; ). Identification of novel alpha- and gammaherpesviruses from cutaneous and mucosal lesions of dolphins and whales. . J Virol Methods 136:, 261–266. [CrossRef] [PubMed]
    [Google Scholar]
  28. Syrjänen S., Leimola-Virtanen R., Schmidt-Westhausen A., Reichart P. A.. ( 1999; ). Oral ulcers in AIDS patients frequently associated with cytomegalovirus (CMV) and Epstein-Barr virus (EBV) infections. . J Oral Pathol Med 28:, 204–209. [CrossRef] [PubMed]
    [Google Scholar]
  29. Tamura K., Stecher G., Peterson D., Filipski A., Kumar S.. ( 2013; ). MEGA6: Molecular Evolutionary Genetics Analysis version 6.0. . Mol Biol Evol 30:, 2725–2729. [CrossRef] [PubMed]
    [Google Scholar]
  30. Toyoda H., Nomura C., Watanabe M., Takahama K., Hobara R., Yokozaki S., Fukuda Y., Nakano H.. ( 2000; ). Investigation of the association between infection with Helicobacter pylori and with TT virus, a novel DNA virus, in patients with gastroduodenal ulcer or ulcer scar. . Eur J Gastroenterol Hepatol 12:, 1289–1293. [CrossRef] [PubMed]
    [Google Scholar]
  31. Tseng M., Fleetwood M., Reed A., Gill V. A., Harris R. K., Moeller R. B., Lipscomb T. P., Mazet J. A., Goldstein T.. ( 2012; ). Mustelid herpesvirus-2, a novel herpes infection in northern sea otters (Enhydra lutris kenyoni). . J Wildl Dis 48:, 181–185. [CrossRef] [PubMed]
    [Google Scholar]
  32. van den Brand J. M., van Leeuwen M., Schapendonk C. M., Simon J. H., Haagmans B. L., Osterhaus A. D., Smits S. L.. ( 2012; ). Metagenomic analysis of the viral flora of pine marten and European badger feces. . J Virol 86:, 2360–2365. [CrossRef] [PubMed]
    [Google Scholar]
  33. van Leeuwen M., Williams M. M., Koraka P., Simon J. H., Smits S. L., Osterhaus A. D.. ( 2010; ). Human picobirnaviruses identified by molecular screening of diarrhea samples. . J Clin Microbiol 48:, 1787–1794. [CrossRef] [PubMed]
    [Google Scholar]
  34. VanDevanter D. R., Warrener P., Bennett L., Schultz E. R., Coulter S., Garber R. L., Rose T. M.. ( 1996; ). Detection and analysis of diverse herpesviral species by consensus primer PCR. . J Clin Microbiol 34:, 1666–1671.[PubMed]
    [Google Scholar]
  35. Venn-Watson S., Benham C., Gulland F. M., Smith C. R., St Leger J., Yochem P., Nollens H., Blas-Machado U., Saliki J. et al. ( 2012; ). Clinical relevance of novel Otarine herpesvirus-3 in California sea lions (Zalophus californianus): lymphoma, esophageal ulcers, and strandings. . Vet Res 43:, 85. [CrossRef] [PubMed]
    [Google Scholar]
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