Skip to content
1887

Abstract

Viruses assigned to the realm have linear, dsDNA genomes in which the DNA is structured in the A-form rather than the usual B-form. Virions are flexible or rigid filaments, with or without envelopes. Adnavirians share homologous major capsid proteins (MCPs) with a distinct -helical structural fold not observed in other known viruses. The MCPs form homodimeric or heterodimeric capsomers that wrap around and condense the genomic dsDNA into helically symmetrical virions. Adnavirians infect hyperthermophilic, thermoacidophilic and methanotrophic archaea. This is a summary of the International Committee on Taxonomy of Viruses Report on the realm , which is available at ictv.global/report/adnaviria.

Funding
This study was supported by the:
  • Division of Intramural Research, National Institute of Allergy and Infectious Diseases (Award HHSN272201800013C)
    • Principal Award Recipient: JensH. Kuhn
  • This is an open-access article distributed under the terms of the Creative Commons Attribution License
Loading

Article metrics loading...

/content/journal/jgv/10.1099/jgv.0.002091
2025-03-26
2026-04-14

Metrics

Loading full text...

Full text loading...

/deliver/fulltext/jgv/106/3/jgv002091.html?itemId=/content/journal/jgv/10.1099/jgv.0.002091&mimeType=html&fmt=ahah

References

  1. Baquero DP, Liu Y, Wang F, Egelman EH, Prangishvili D et al. Structure and assembly of archaeal viruses. Adv Virus Res 2020; 108:127–164 [View Article] [PubMed]
    [Google Scholar]
  2. Wang F, Baquero DP, Beltran LC, Su Z, Osinski T et al. Structures of filamentous viruses infecting hyperthermophilic archaea explain DNA stabilization in extreme environments. Proc Natl Acad Sci USA 2020; 117:19643–19652 [View Article] [PubMed]
    [Google Scholar]
  3. DiMaio F, Yu X, Rensen E, Krupovic M, Prangishvili D et al. Virology. A virus that infects a hyperthermophile encapsidates A-form DNA. Science 2015; 348:914–917 [View Article] [PubMed]
    [Google Scholar]
  4. Liu Y, Osinski T, Wang F, Krupovic M, Schouten S et al. Structural conservation in a membrane-enveloped filamentous virus infecting a hyperthermophilic acidophile. Nat Commun 2018; 9:3360 [View Article]
    [Google Scholar]
  5. Kasson P, DiMaio F, Yu X, Lucas-Staat S, Krupovic M et al. Model for a novel membrane envelope in a filamentous hyperthermophilic virus. Elife 2017; 6:e26268 [View Article] [PubMed]
    [Google Scholar]
  6. Wang F, Baquero DP, Su Z, Osinski T, Prangishvili D et al. Structure of a filamentous virus uncovers familial ties within the archaeal virosphere. Virus Evol 2020; 6:veaa023 [View Article] [PubMed]
    [Google Scholar]
  7. Blum H, Zillig W, Mallok S, Domdey H, Prangishvili D. The genome of the archaeal virus SIRV1 has features in common with genomes of eukaryal viruses. Virology 2001; 281:6–9 [View Article] [PubMed]
    [Google Scholar]
  8. Pina M, Basta T, Quax TEF, Joubert A, Baconnais S et al. Unique genome replication mechanism of the archaeal virus AFV1. Mol Microbiol 2014; 92:1313–1325 [View Article] [PubMed]
    [Google Scholar]
  9. Baquero DP, Gazi AD, Sachse M, Liu J, Schmitt C et al. A filamentous archaeal virus is enveloped inside the cell and released through pyramidal portals. Proc Natl Acad Sci USA 2021; 118:e2105540118 [View Article] [PubMed]
    [Google Scholar]
  10. Krupovic M, Kuhn JH, Wang F, Baquero DP, Dolja VV et al. Adnaviria: a new realm for archaeal filamentous viruses with linear A-form double-stranded DNA genomes. J Virol 2021; 95:e0067321 [View Article] [PubMed]
    [Google Scholar]
/content/journal/jgv/10.1099/jgv.0.002091
Loading
/content/journal/jgv/10.1099/jgv.0.002091
Loading

Data & Media loading...

This is a required field
Please enter a valid email address
Approval was a Success
Invalid data
An error occurred
Approval was partially successful, following selected items could not be processed due to error