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Abstract

Enteric hepatitis, represented by the hepatitis A virus (HAV) and hepatitis E virus (HEV), remains a significant global public health concern. While much progress has been made, many aspects of the biology and pathophysiology of HAV and HEV are still not fully understood. One of the major challenges is the absence of a reliable system for virus replication. Additionally, the lack of standardized and widely accessible diagnostic tests contributes to the underestimation of the true prevalence of these viruses. Factors such as climate change, environmental shifts, globalization and increased population mobility further complicate the spread of these infections by affecting pathogen transmission, water quality and the distribution of vectors. This review approaches the emergent research challenges and trends of enteric hepatitis and focuses on developing more efficient diagnostic tools, exploring the role of zoonotic transmission and addressing the impact of environmental and climate changes on disease dynamics, underscoring the need for collaborative, interdisciplinary efforts to effectively combat enteric hepatitis in a rapidly changing world.

Funding
This study was supported by the:
  • Coordination for the Improvement of Higher Education Personnel (CAPES) (Award 88887.910938/2023-00)
    • Principle Award Recipient: MarianaAlves Elois
  • Fundação de Amparo à Pesquisa e Inovação do Estado de Santa Catarina (Award 2022TR002036/ FAPESC 30/2022)
    • Principle Award Recipient: GislaineFongaro
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/content/journal/jgv/10.1099/jgv.0.002059
2024-12-18
2025-02-13
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