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Volume 105, Issue 10

Oropouche Virus: An Emerging Orthobunyavirus Open Access

Abstract

On 2 February 2024, the Pan American Health Organization/World Health Organization issued an epidemiological alert on rising Oropouche virus (OROV) infections in South America. By 3 August 2024, this alert level had escalated from medium to high. OROV has been a public health concern in Central and South America since its emergence in Brazil in the 1960s. However, the 2024 outbreak marks a turning point, with the sustained transmission in non-endemic regions of Brazil, local transmission in Cuba, two fatalities and several cases of vertical transmission. As of the end of August 2024, 9852 OROV cases have been confirmed. The 2024 OROV outbreak underscores critical gaps in our understanding of OROV pathogenesis and highlights the urgent need for antivirals and vaccines. This review aims to provide a concise overview of OROV, a neglected orthobunyavirus.

  • Received:
  • Accepted:
  • Published Online:
Keyword(s): arbovirus , emerging virus , Oropouche virus , orthobunyavirus and reassortment
Funding
This study was supported by the:
  • Indiana University-Purdue University Indianapolis
    • Principle Award Recipient: NatashaLouise Tilston-Lunel
  • Ralph W. and Grace M. Showalter Research Trust Fund (Award Showalter.2023.20)
    • Principle Award Recipient: NatashaLouise Tilston-Lunel
  • Division of Intramural Research, National Institute of Allergy and Infectious Diseases (Award R00AI153464)
    • Principle Award Recipient: NatashaLouise Tilston-Lunel
© 2024 The Authors
  • This is an open-access article distributed under the terms of the Creative Commons Attribution License. This article was made open access via a Publish and Read agreement between the Microbiology Society and the corresponding author’s institution.
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Oropouche Virus: An Emerging Orthobunyavirus
J. Gen. Virol. 105, 002027 (2024); https://doi.org/10.1099/jgv.0.002027
/content/journal/jgv/10.1099/jgv.0.002027
/content/journal/jgv/10.1099/jgv.0.002027
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