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Volume 105, Issue 8

Mouse cytomegalovirus lacking sgg1 shows reduced import into the salivary glands Open Access

Abstract

Cytomegaloviruses (CMVs) transmit via chronic shedding from the salivary glands. How this relates to the broad cell tropism they exhibit is unclear. Human CMV (HCMV) infection presents only after salivary gland infection is established. Murine CMV (MCMV) is therefore useful to analyse early infection events. It reaches the salivary glands via infected myeloid cells. Three adjacent spliced genes designated as m131/129 (MCK-2), sgg1 and sgg1.1, positional homologues of the HCMV UL128/130/131 tropism determinants, are implicated. We show that a sgg1 null mutant is defective in infected myeloid cell entry into the salivary glands, a phenotype distinct from MCMV lacking MCK-2. These data point to a complex, multi-step process of salivary gland colonization.

  • Received:
  • Accepted:
  • Published Online:
Keyword(s): cytomegalovirus , myeloid cells and salivary glands
Funding
This study was supported by the:
  • Australian Research Council (Award DP190101851)
    • Principle Award Recipient: PhilipG. Stevenson
  • National Health and Medical Research Council (Award 1140169)
    • Principle Award Recipient: PhilipG. Stevenson
© 2024 The Authors
  • This is an open-access article distributed under the terms of the Creative Commons Attribution License. This article was made open access via a Publish and Read agreement between the Microbiology Society and the corresponding author’s institution.
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2024-08-02
2024-09-15
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Mouse cytomegalovirus lacking sgg1 shows reduced import into the salivary glands
J. Gen. Virol. 105, 002013 (2024); https://doi.org/10.1099/jgv.0.002013
/content/journal/jgv/10.1099/jgv.0.002013
/content/journal/jgv/10.1099/jgv.0.002013
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