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Journal of General Virology header logo Journal of General Virology

Volume 105, Issue 5

Downregulation of KLF5 by EBER1 via the ERK signaling pathway in EBV-positive nasopharyngeal carcinoma cells: implications for latent EBV infection No Access

Abstract

Nasopharyngeal carcinoma (NPC) carcinogenesis and malignant transformation are intimately associated with Epstein-Barr virus (EBV) infection. A zinc-fingered transcription factor known as Krüppel-like factor 5 (KLF5) has been shown to be aberrantly expressed in a number of cancer types. However, little is known about the regulatory pathways and roles of KLF5 in EBV-positive NPC. Our study found that KLF5 expression was significantly lower in EBV-positive NPC than in EBV-negative NPC. Further investigation revealed that EBER1, which is encoded by EBV, down-regulates KLF5 via the extracellular signal-regulated kinase (ERK) signalling pathway. This down-regulation of KLF5 by EBER1 contributes to maintaining latent EBV infection in NPC. Furthermore, we uncovered the biological roles of KLF5 in NPC cells. Specifically, KLF5 may influence the cell cycle, prevent apoptosis, and encourage cell migration and proliferation – all of which have a generally pro-cancer impact. In conclusion, these findings offer novel strategies for EBV-positive NPC patients’ antitumour treatment.

  • Received:
  • Accepted:
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Keyword(s): EBER1 , Epstein-Barr virus , ERK , Krüppel-like factor 5 and nasopharyngeal carcinoma
Funding
This study was supported by the:
  • Clinical Medicine+X Project of the Affiliated Hospital of Qingdao University (Award QDFY+X202101023)
    • Principle Award Recipient: ShuzhenLiu
© 2024 The Authors
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/content/journal/jgv/10.1099/jgv.0.001988
2024-05-15
2025-05-21
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/content/journal/jgv/10.1099/jgv.0.001988
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Downregulation of KLF5 by EBER1 via the ERK signaling pathway in EBV-positive nasopharyngeal carcinoma cells: implications for latent EBV infection
J. Gen. Virol. 105, 001988 (2024); https://doi.org/10.1099/jgv.0.001988
/content/journal/jgv/10.1099/jgv.0.001988
/content/journal/jgv/10.1099/jgv.0.001988
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