1887

Abstract

Host control of mouse cytomegalovirus (MCMV) infection of MHCII salivary gland acinar cells is mediated by CD4 T cells, but how they protect is unclear. Here, we show CD4 T cells control MCMV indirectly in the salivary gland, via IFNγ engagement with uninfected, but antigen MHCII APC and recruitment of NK cells to infected cell foci. This immune mechanism renders direct contact of CD4 T cells with infected cells unnecessary and may represent a host strategy to overcome viral immune evasion.

Funding
This study was supported by the:
  • Queensland Health
    • Principle Award Recipient: PhilipStevenson
  • Australian Research Council (Award DP190101851)
    • Principle Award Recipient: PhilipStevenson
  • National Health and Medical Research Council (Award 1140169)
    • Principle Award Recipient: PhilipStevenson
  • This is an open-access article distributed under the terms of the Creative Commons Attribution License. This article was made open access via a Publish and Read agreement between the Microbiology Society and the corresponding author’s institution.
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2024-01-25
2024-11-12
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