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, Danushka K. Wijesundara1,3, Jovin J. Y. Choo1, Alberto A. Amarilla1, Naphak Modhiran1, Germain J. P. Fernando1,3, Alexander A. Khromykh1,2, Daniel Watterson1,2, Paul R. Young1,2 and David A. Muller1,2
The COVID-19 pandemic has highlighted the need for vaccines capable of providing rapid and robust protection. One way to improve vaccine efficacy is delivery via microarray patches, such as the Vaxxas high-density microarray patch (HD-MAP). We have previously demonstrated that delivery of a SARS-CoV-2 protein vaccine candidate, HexaPro, via the HD-MAP induces potent humoral immune responses. Here, we investigate the cellular responses induced by HexaPro HD-MAP vaccination. We found that delivery via the HD-MAP induces a type one biassed cellular response of much greater magnitude as compared to standard intramuscular immunization.
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