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Volume 103, Issue 6

Embracing the heterogeneity of natural viruses in mouse studies Open Access

Abstract

Animal models are a critical tool in modern biology. To increase reproducibility and to reduce confounding variables modern animal models exclude many microbes, including key natural commensals and pathogens. Here we discuss recent strategies to incorporate a natural microbiota to laboratory mouse models and the impacts the microbiota has on immune responses, with a focus on viruses.

  • Received:
  • Accepted:
  • Published Online:
Keyword(s): dirty mice , microbiome and virome
Funding
This study was supported by the:
  • University of Minnesota McKnight Foundation (Award N.A.)
    • Principle Award Recipient: RyanA. Langlois
  • Foundation for the National Institutes of Health (Award AI50600)
    • Principle Award Recipient: RyanA. Langlois
© 2022 The Authors
  • This is an open-access article distributed under the terms of the Creative Commons Attribution License. This article was made open access via a Publish and Read agreement between the Microbiology Society and the corresponding author’s institution.
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2022-06-23
2024-04-18
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Embracing the heterogeneity of natural viruses in mouse studies
J. Gen. Virol. 103, 001758 (2022); https://doi.org/10.1099/jgv.0.001758
/content/journal/jgv/10.1099/jgv.0.001758
/content/journal/jgv/10.1099/jgv.0.001758
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