1887

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Volume 103, Issue 4

History and classification of Aigai virus (formerly Crimean–Congo haemorrhagic fever virus genotype VI) No Access

Abstract

Crimean–Congo haemorrhagic fever virus (CCHFV) is the medically most important member of the rapidly expanding bunyaviral family . Traditionally, CCHFV isolates have been assigned to six distinct genotypes. Here, the International Committee on Taxonomy of Viruses (ICTV) Study Group outlines the reasons for the recent decision to re-classify genogroup VI (aka Europe-2 or AP-92-like) as a distinct virus, Aigai virus (AIGV).

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Keyword(s): Aigai virus , AIGV , Crimean–Congo hemorrhagic fever , Nairoviridae and orthonairovirus
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2022-04-12
2024-04-23
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References

  1. Иоффе ВЮ. Об одной своеобразной форме геморрагического диатеза. Клин Мед (Моск) 1944; 22:25–30
     [Google Scholar]
  2. Сиповский ПВ. Случаи своеобразного желудочно-кишечного кровотечения. Клин Мед (Моск) 1944; 22:64–67
     [Google Scholar]
  3. Соколов AE, Чумаков МП, Колачев АА. Крымская геморрагическая лихорадка (острый инфекционный капилляротоксикоз). Simferopol, Crimean Autonomous Soviet Socialist Republic of the USSR Издание Отдельной Приморской Армии; 1945
     [Google Scholar]
  4. Belobo JTE, Kenmoe S, Kengne-Nde C, Emoh CPD, Bowo-Ngandji A et al. Worldwide epidemiology of Crimean-Congo hemorrhagic fever virus in humans, ticks and other animal species, a systematic review and meta-analysis. PLoS Negl Trop Dis 2021; 15:e0009299 [View Article] [PubMed]
     [Google Scholar]
  5. Blair PW, Kuhn JH, Pecor DB, Apanaskevich DA, Kortepeter MG et al. An emerging biothreat: Crimean-Congo hemorrhagic fever virus in Southern and Western Asia. Am J Trop Med Hyg 2019; 100:16–23 [View Article] [PubMed]
     [Google Scholar]
  6. Hoogstraal H. The epidemiology of tick-borne Crimean-Congo hemorrhagic fever in Asia, Europe, and Africa. J Med Entomol 1979; 15:307–417 [View Article] [PubMed]
     [Google Scholar]
  7. Pigott DM, Deshpande A, Letourneau I, Morozoff C, Reiner RC Jr et al. Local, national, and regional viral haemorrhagic fever pandemic potential in Africa: a multistage analysis. Lancet 2017; 390:2662–2672 [View Article] [PubMed]
     [Google Scholar]
  8. Temur AI, Kuhn JH, Pecor DB, Apanaskevich DA, Keshtkar-Jahromi M. Epidemiology of Crimean-Congo hemorrhagic fever (CCHF) in Africa—underestimated for decades. Am J Trop Med Hyg 2021; 104:1978–1990 [View Article] [PubMed]
     [Google Scholar]
  9. Al-Abri SS, Hewson R, Al-Kindi H, Al-Abaidani I, Al-Jardani A et al. Clinical and molecular epidemiology of Crimean-Congo hemorrhagic fever in Oman. PLoS Negl Trop Dis 2019; 13:e0007100 [View Article] [PubMed]
     [Google Scholar]
  10. Bodur H, Akinci E, Ascioglu S, Öngürü P, Uyar Y. Subclinical infections with Crimean-Congo hemorrhagic fever virus, Turkey. Emerg Infect Dis 2012; 18:640–642 [View Article] [PubMed]
     [Google Scholar]
  11. Ergonul O. Clinical and pathologic features of Crimean-Congo hemorrhagic fever. In Ergonul O, Whitehouse CA. eds Crimean-Congo Hemorrhagic Fever: A Global Perspective Whitehouse. Dordrecht, Netherlands: Springer; 2007207–220
     [Google Scholar]
  12. Sağmak Tartar A, Balin SÖ, Akbulut A, Demirdağ K. Türkiye’nin doğusunda Kırım Kongo kanamalı ateşi: epidemiyolojik ve klinik değerlendirme. Türk Parazitol Derg 2019; 43:26–29 [View Article]
     [Google Scholar]
  13. Schwarz TF, Nsanze H, Ameen AM. Clinical features of Crimean-Congo haemorrhagic fever in the United Arab Emirates. Infection 1997; 25:364–367 [View Article] [PubMed]
     [Google Scholar]
  14. Tripathi S, Bhati R, Gopalakrishnan M, Bohra GK, Tiwari S et al. Clinical profile and outcome of patients with Crimean Congo haemorrhagic fever: a hospital based observational study from Rajasthan, India. Trans R Soc Trop Med Hyg 2020; 114:643–649 [View Article] [PubMed]
     [Google Scholar]
  15. Simpson DI, Knight EM, Courtois G, Williams MC, Weinbren MP et al. Congo virus: a hitherto undescribed virus occurring in Africa. I. Human isolations—clinical notes. East Afr Med J 1967; 44:86–92 [PubMed]
     [Google Scholar]
  16. Woodall JP. Personal reflections. In Ergonul O, Whitehouse CA. eds Crimean-Congo Hemorrhagic Fever: A Global Perspective Dordrecht, Netherlands: Springer; 200723–32
     [Google Scholar]
  17. Woodall JP, Williams MC, Simpson DIH. Congo virus: a hitherto undescribed virus occurring in Africa. Part 2—identification studies. E Afr Med J 1967; 44:93–98
     [Google Scholar]
  18. Casals J. Antigenic similarity between the virus causing Crimean hemorrhagic fever and Congo virus. Proc Soc Exp Biol Med 1969; 131:233–236 [View Article] [PubMed]
     [Google Scholar]
  19. Chumakov MP, Smirnova SE, Tkachenko EA. Relationship between strains of Crimean haemorrhagic fever and Congo viruses. Acta Virol 1970; 14:82–85 [PubMed]
     [Google Scholar]
  20. Чумаков МП, Бутенко АМ, Шалунова НВ, Мартьянова ЛИ, Смирнова СЕ et al. Новые данные о вирусе-возбудителе крымской геморрагической лихорадки. вопр вирусол; 1968; 13377
  21. Garrison AR, Alkhovsky [Альховский Сергей Владимирович] SV, Avšič-Županc T, Bente DA, Bergeron É et al. ICTV virus taxonomy profile: Nairoviridae. J Gen Virol 2020; 101:798–799 [View Article]
     [Google Scholar]
  22. Kuhn JH, Adkins S, Agwanda BR, Al Kubrusli R, Alkhovsky SV et al. 2021 Taxonomic update of phylum Negarnaviricota (Riboviria: Orthornavirae), including the large orders Bunyavirales and Mononegavirales. Arch Virol 2021; 166:3513–3566 [View Article] [PubMed]
     [Google Scholar]
  23. Gargili A, Estrada-Peña A, Spengler JR, Lukashev A, Nuttall PA et al. The role of ticks in the maintenance and transmission of Crimean-Congo hemorrhagic fever virus: A review of published field and laboratory studies. Antiviral Res 2017; 144:93–119 [View Article] [PubMed]
     [Google Scholar]
  24. Spengler JR, Estrada-Peña A, Garrison AR, Schmaljohn C, Spiropoulou CF et al. A chronological review of experimental infection studies of the role of wild animals and livestock in the maintenance and transmission of Crimean-Congo hemorrhagic fever virus. Antiviral Res 2016; 135:31–47 [View Article] [PubMed]
     [Google Scholar]
  25. Anagnostou V, Papa A. Evolution of Crimean-Congo hemorrhagic fever virus. Infect Genet Evol 2009; 9:948–954 [View Article] [PubMed]
     [Google Scholar]
  26. Carroll SA, Bird BH, Rollin PE, Nichol ST. Ancient common ancestry of Crimean-Congo hemorrhagic fever virus. Mol Phylogenet Evol 2010; 55:1103–1110 [View Article] [PubMed]
     [Google Scholar]
  27. Chamberlain J, Cook N, Lloyd G, Mioulet V, Tolley H et al. Co-evolutionary patterns of variation in small and large RNA segments of Crimean-Congo hemorrhagic fever virus. J Gen Virol 2005; 86:3337–3341 [View Article] [PubMed]
     [Google Scholar]
  28. Deyde VM, Khristova ML, Rollin PE, Ksiazek TG, Nichol ST. Crimean-Congo hemorrhagic fever virus genomics and global diversity. J Virol 2006; 80:8834–8842 [View Article] [PubMed]
     [Google Scholar]
  29. Grard G, Drexler JF, Fair J, Muyembe JJ, Wolfe ND et al. Re-emergence of Crimean-Congo hemorrhagic fever virus in Central Africa. PLoS Negl Trop Dis 2011; 5:e1350 [View Article] [PubMed]
     [Google Scholar]
  30. Hewson R, Chamberlain J, Mioulet V, Lloyd G, Jamil B et al. Crimean-Congo haemorrhagic fever virus: sequence analysis of the small RNA segments from a collection of viruses world wide. Virus Res 2004; 102:185–189 [View Article] [PubMed]
     [Google Scholar]
  31. Lukashev AN, Klimentov AS, Smirnova SE, Dzagurova TK, Drexler JF et al. Phylogeography of Crimean Congo hemorrhagic fever virus. PLoS One 2016; 11:e0166744 [View Article] [PubMed]
     [Google Scholar]
  32. Papadopoulos O, Koptopoulos G. Crimean-Congo hemorrhagic fever (CCHF) in Greece: isolation of the virus from Rhipicephalus bursa ticks and a preliminary serological survey. In Vesenjak-Hirjan J, Porterfield JS. eds Arboviruses in the Mediterranean Countries. Zentralblatt für Bakteriologie Supplementum 9 Stuttgart, Germany: Gustav Fisher Verlag; 1980 pp 189–193
     [Google Scholar]
  33. Παπαδόπουλος Ο, Κοπτόπουλος Γ. Απομόνωση ιου της ομαδας κριμα∙ι∙κου αιμορραγικου πυρετου-κογκο απο κροτωνες Rhipicephalus bursa. Δελτίον Ελληνικής Μικροβιολογικής Εταιρείας 1978; 23:20–28
     [Google Scholar]
  34. Παπαδόπουλος Ο, Πασχαλέρη-Παπαδοπούλου Ε, Δεληγκάρης Ν, Δούκας Γ. Απομονωσις ιου της κροτωνογενους εγκεφαλιτιδος εκ ποιμνιου αιγων με αποβολας και θανατηφορον νοσον (προδρομος ανακοινωσις). Κτηνιατρικά Νέα 1971; 3:112–114
     [Google Scholar]
  35. Antoniadis A, Casals J. Serological evidence of human infection with Congo-Crimean hemorrhagic fever virus in Greece. Am J Trop Med Hyg 1982; 31:1066–1067 [View Article] [PubMed]
     [Google Scholar]
  36. Antoniadis A, Alexiou-Daniel S, Malissiovas N, Doutsos J, Polyzoni T et al. Seroepidemiological survey for antibodies to arboviruses in Greece. In Calisher CH. eds Archives of Virology Supplementum, Vol. 1: Hemorrhagic Fever with Renal Syndrome, Tick and Mosquito-Borne Viruses Springer: Vienna, Austria; 1990 pp 277–285
     [Google Scholar]
  37. Antoniadis A, Polizoni T, Tomori O, Williams O, Marriott AC et al. Evidence of previously unrecognised nairovirus infections of humans in Nigeria and Greece. J Vir Dis 1992; 1:34–39
     [Google Scholar]
  38. Marriott AC, Polyzoni T, Antoniadis A, Nuttall PA. Detection of human antibodies to Crimean-Congo haemorrhagic fever virus using expressed viral nucleocapsid protein. J Gen Virol 1994; 75 (Pt 9):2157–2161 [View Article] [PubMed]
     [Google Scholar]
  39. Papa A, Papadimitriou E, Antoniadis A. Genetic characterization of the M RNA segment of Crimean-Congo hemorrhagic fever virus strain AP92. In Abstracts of the XIIIth International Conference on Negative Strand Viruses Salamanca, Spain: 2006 p 102
     [Google Scholar]
  40. Papa A, Maltezou HC, Tsiodras S, Dalla VG, Papadimitriou T et al. A case of Crimean-Congo haemorrhagic fever in Greece, June 2008. Euro Surveill 2008; 13:18952 [View Article] [PubMed]
     [Google Scholar]
  41. Papa A, Dalla V, Papadimitriou E, Kartalis GN, Antoniadis A. Emergence of Crimean-Congo haemorrhagic fever in Greece. Clin Microbiol Infect 2010; 16:843–847 [View Article] [PubMed]
     [Google Scholar]
  42. Papa A, Markatou F, Maltezou HC, Papadopoulou E, Terzi E et al. Crimean-Congo haemorrhagic fever in a Greek worker returning from Bulgaria, June 2018. Euro Surveill 2018; 23: [View Article] [PubMed]
     [Google Scholar]
  43. Schuster I, Chaintoutis SC, Dovas CI, Groschup MH, Mertens M. Detection of Crimean-Congo hemorrhagic fever virus-specific IgG antibodies in ruminants residing in Central and Western Macedonia, Greece. Ticks Tick Borne Dis 2017; 8:494–498 [View Article] [PubMed]
     [Google Scholar]
  44. Papa A, Sidira P, Kallia S, Ntouska M, Zotos N et al. Factors associated with IgG positivity to Crimean-Congo hemorrhagic fever virus in the area with the highest seroprevalence in Greece. Ticks Tick Borne Dis 2013; 4:417–420 [View Article] [PubMed]
     [Google Scholar]
  45. Papa A, Sidira P, Larichev V, Gavrilova L, Kuzmina K et al. Crimean-Congo hemorrhagic fever virus, Greece. Emerg Infect Dis 2014; 20:288–290 [View Article] [PubMed]
     [Google Scholar]
  46. Papa A, Sidira P, Tsatsaris A. Spatial cluster analysis of Crimean-Congo hemorrhagic fever virus seroprevalence in humans, Greece. Parasite Epidemiol Control 2016; 1:211–218 [View Article] [PubMed]
     [Google Scholar]
  47. Papa A, Tzala E, Maltezou HC. Crimean-Congo hemorrhagic fever virus, northeastern Greece. Emerg Infect Dis 2011; 17:141–143 [View Article] [PubMed]
     [Google Scholar]
  48. Sargianou M, Panos G, Tsatsaris A, Gogos C, Papa A. Crimean-Congo hemorrhagic fever: seroprevalence and risk factors among humans in Achaia, western Greece. Int J Infect Dis 2013; 17:e1160–5 [View Article] [PubMed]
     [Google Scholar]
  49. Sidira P, Maltezou HC, Haidich AB, Papa A. Seroepidemiological study of Crimean-Congo haemorrhagic fever in Greece, 2009-2010. Clin Microbiol Infect 2012; 18:E16–9 [View Article] [PubMed]
     [Google Scholar]
  50. Sidira P, Nikza P, Danis K, Panagiotopoulos T, Samara D et al. Prevalence of Crimean-Congo hemorrhagic fever virus antibodies in Greek residents in the area where the AP92 strain was isolated. Hippokratia 2013; 17:322–325 [PubMed]
     [Google Scholar]
  51. Papa A, Chaligiannis I, Kontana N, Sourba T, Tsioka K et al. A novel AP92-like Crimean-Congo hemorrhagic fever virus strain, Greece. Ticks Tick Borne Dis 2014; 5:590–593 [View Article] [PubMed]
     [Google Scholar]
  52. Papa A, Kontana A, Tsioka K, Chaligiannis I, Sotiraki S. Molecular detection of Crimean-Congo hemorrhagic fever virus in ticks, Greece, 2012-2014. Parasitol Res 2017; 116:3057–3063 [View Article] [PubMed]
     [Google Scholar]
  53. Papa A, Papadopoulou E, Tsioka K, Kontana A, Pappa S et al. Isolation and whole-genome sequencing of a Crimean-Congo hemorrhagic fever virus strain, Greece. Ticks Tick Borne Dis 2018; 9:788–791 [View Article] [PubMed]
     [Google Scholar]
  54. Emmerich P, Jakupi X, von Possel R, Berisha L, Halili B et al. Viral metagenomics, genetic and evolutionary characteristics of Crimean-Congo hemorrhagic fever orthonairovirus in humans, Kosovo. Infect Genet Evol 2018; 65:6–11 [View Article] [PubMed]
     [Google Scholar]
  55. Panayotova E, Papa A, Trifonova I, Christova I. Crimean-Congo hemorrhagic fever virus lineages Europe 1 and Europe 2 in Bulgarian ticks. Ticks Tick Borne Dis 2016; 7:1024–1028 [View Article] [PubMed]
     [Google Scholar]
  56. Papa A, Velo E, Kadiaj P, Tsioka K, Kontana A et al. Crimean-Congo hemorrhagic fever virus in ticks collected from livestock in Albania. Infect Genet Evol 2017; 54:496–500 [View Article] [PubMed]
     [Google Scholar]
  57. Sherifi K, Cadar D, Muji S, Robaj A, Ahmeti S et al. Crimean-Congo hemorrhagic fever virus clades V and VI (Europe 1 and 2) in ticks in Kosovo, 2012. PLoS Negl Trop Dis 2014; 8:e3168 [View Article] [PubMed]
     [Google Scholar]
  58. Ergünay K, Dinçer E, Kar S, Emanet N, Yalçınkaya D et al. Multiple orthonairoviruses including Crimean-Congo hemorrhagic fever virus, Tamdy virus and the novel Meram virus in Anatolia. Ticks Tick Borne Dis 2020; 11:101448 [View Article] [PubMed]
     [Google Scholar]
  59. Gargili A, Midilli K, Ergonul O, Ergin S, Alp HG et al. Crimean-Congo hemorrhagic fever in European part of Turkey: genetic analysis of the virus strains from ticks and a seroepidemiological study in humans. Vector Borne Zoonotic Dis 2011; 11:747–752 [View Article] [PubMed]
     [Google Scholar]
  60. Dinçer E, Brinkmann A, Hekimoğlu O, Hacıoğlu S, Földes K et al. Generic amplification and next generation sequencing reveal Crimean-Congo hemorrhagic fever virus AP92-like strain and distinct tick phleboviruses in Anatolia, Turkey. Parasit Vectors 2017; 10:335 [View Article] [PubMed]
     [Google Scholar]
  61. Kautman M, Tiar G, Papa A, Široký P. AP92-like Crimean-Congo Hemorrhagic Fever Virus in Hyalomma aegyptium Ticks, Algeria. Emerg Infect Dis 2016; 22:354–356 [View Article] [PubMed]
     [Google Scholar]
  62. Midilli K, Gargili A, Ergonul O, Elevli M, Ergin S et al. The first clinical case due to AP92 like strain of Crimean-Congo Hemorrhagic Fever virus and a field survey. BMC Infect Dis 2009; 9:90 [View Article] [PubMed]
     [Google Scholar]
  63. Salehi-Vaziri M, Baniasadi V, Jalali T, Mirghiasi SM, Azad-Manjiri S et al. The first fatal case of Crimean-Congo hemorrhagic fever caused by the AP92-Like strain of the Crimean-Congo hemorrhagic fever virus. Jpn J Infect Dis 2016; 69:344–346 [View Article] [PubMed]
     [Google Scholar]
  64. Zehender G, Ebranati E, Shkjezi R, Papa A, Luzzago C et al. Bayesian phylogeography of Crimean-Congo hemorrhagic fever virus in Europe. PLoS One 2013; 8:e79663 [View Article] [PubMed]
     [Google Scholar]
  65. Marklewitz M, Paraskevopoulou S, Alkhovsky SV, Avšič-Županc T, Bente D et al. Create four new genera and 30 new species (Bunyavirales: Nairoviridae). ICTV [International Committee on Taxonomy of Viurses] TaxoProp 2020.027M.R.Nairoviridae_4ngen_30nsp; 2020 https://talk.ictvonline.org/taxonomy/p/taxonomy-history?taxnode_id=202009762
  66. Walker PJ, Siddell SG, Lefkowitz EJ, Mushegian AR, Adriaenssens EM et al. Changes to virus taxonomy and to the International Code of Virus Classification and Nomenclature ratified by the International Committee on Taxonomy of Viruses (2021). Arch Virol 2021; 166:2633–2648 [View Article]
     [Google Scholar]
  67. Adriaenssens EM, Dutilh BE, Harrach B, Junglen S, Kropinski A et al. Modify the International Code of Virus Classification and Nomenclature (ICVCN) to prospectively mandate a uniform genus-species type virus species naming format. ICTV [International Committee for Taxonomy of Viruses] Proposal (Taxoprop) no.2018.001G.R.binomial_species; 2021 https://talk.ictvonline.org/files/ictv_official_taxonomy_updates_since_the_8th_report/m/general-2008/11058
  68. Postler TS, Kuhn JH. Rename all species in the family to comply with the ICTV-mandated binomial format (Bunyavirales: Nairoviridae). ICTV [International Committee on Taxonomy of Viurses] TaxoProp 2021.017M.N.v1.Nairoviridae_sprenamed; 2021 https://talk.ictvonline.org/files/proposals/animal_dsrna_and_ssrna-_viruses/m/animal_rna_minus_under_consideration/12837
  69. CABI Invasive Species Compendium Rhipicephalus bursa; 2019 https://www.cabi.org/isc/datasheet/65996#tohostAnimals
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History and classification of Aigai virus (formerly Crimean–Congo haemorrhagic fever virus genotype VI)
J. Gen. Virol. 103, 001734 (2022); https://doi.org/10.1099/jgv.0.001734
/content/journal/jgv/10.1099/jgv.0.001734
/content/journal/jgv/10.1099/jgv.0.001734
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