1887

Abstract

Mosquito-borne flaviviruses are responsible for viral infections and represent a considerable public health burden. is the principal vector of dengue virus (DENV), therefore understanding the intrinsic virus–host interactions is vital, particularly in the presence of the endosymbiont which blocks virus replication in mosquitoes. Here, we examined the transcriptional response of -transinfected Aag2 cells to DENV infection. We identified differentially expressed immune genes that play a key role in the activation of anti-viral defence such as the Toll and immune deficiency pathways. Further, genes encoding cytosine and N-adenosine methyltransferases and SUMOylation, involved in post-transcriptional modifications, an antioxidant enzyme, and heat-shock response were up-regulated at the early stages of DENV infection and are reported here for the first time. Additionally, several long non-coding RNAs were among the differentially regulated genes. Our results provide insight into -transinfected ’s initial virus recognition and transcriptional response to DENV infection.

Funding
This study was supported by the:
  • Australian Research Council (Award DP190102048)
    • Principle Award Recipient: SassanAsgari
  • This is an open-access article distributed under the terms of the Creative Commons Attribution License. This article was made open access via a Publish and Read agreement between the Microbiology Society and the corresponding author’s institution.
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2022-01-10
2022-01-17
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