RT Journal Article SR Electronic(1) A1 Tsugawa, Takeshi A1 Fujii, Yoshiki A1 Akane, Yusuke A1 Honjo, Saho A1 Kondo, Kenji A1 Nihira, Hiroshi A1 Kimura, Hirokazu A1 Kawasaki, YukihikoYR 2021 T1 Molecular characterization of the first human G15 rotavirus strain of zoonotic origin from the bovine species JF Journal of General Virology, VO 102 IS 4 OP SP 001581 DO https://doi.org/10.1099/jgv.0.001581 PB Microbiology Society, SN 1465-2099, AB Group A rotaviruses (RVAs) infect a wide variety of mammalian and avian species. Animals act as a potential reservoir to RVA human infections by direct virion transmission or by contributing genes to reassortants. Here, we report the molecular characterization of a rare human RVA strain Ni17-46 with a genotype G15P[14], isolated in Japan in 2017 during rotavirus surveillance in a paediatric outpatient clinic. The genome constellation of this strain was G15-P[14]-I2-R2-C2-M2-A13-N2-T9-E2-H3. This is the first report of an RVA with G15 genotype in humans, and sequencing and phylogenetic analysis results suggest that human infection with this strain has zoonotic origin from the bovine species. Given the fact that this strain was isolated from a patient with gastroenteritis and dehydration symptoms, we must take into account the virulence of this strain in humans., UL https://www.microbiologyresearch.org/content/journal/jgv/10.1099/jgv.0.001581