1887

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Volume 102, Issue 1

The first decade of research advances in influenza D virus Free

Abstract

From its initial isolation in the USA in 2011 to the present, influenza D virus (IDV) has been detected in cattle and swine populations worldwide. IDV has exceptional thermal and acid stability and a broad host range. The virus utilizes cattle as its natural reservoir and amplification host with periodic spillover to other mammalian species, including swine. IDV infection can cause mild to moderate respiratory illnesses in cattle and has been implicated as a contributor to bovine respiratory disease (BRD) complex, which is the most common and costly disease affecting the cattle industry. Bovine and swine IDV outbreaks continue to increase globally, and there is increasing evidence indicating that IDV may have the potential to infect humans. This review discusses recent advances in IDV biology and epidemiology, and summarizes our current understanding of IDV pathogenesis and zoonotic potential.

  • Received:
  • Accepted:
  • Published Online:
Keyword(s): zoonotic potential , epidemiology , genetic and antigenic evolution , influenza D virus and pathogenicity
Funding
This study was supported by the:
  • University of Kentucky (Award Agricultural Experiment Station)
    • Principle Award Recipient: Feng Li
  • University of Kentucky (Award William Robert Mills Endowment Fund)
    • Principle Award Recipient: Feng Li
  • South Dakota Agricultural Experiment Station (Award 3AH-673)
    • Principle Award Recipient: Feng Li
  • National Institute of Food and Agriculture (Award 2016-67016-24949)
    • Principle Award Recipient: Dan Wang
  • National Institute of Allergy and Infectious Diseases (Award R01AI141889)
    • Principle Award Recipient: Feng Li
© 2021 The Authors
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2020-11-19
2024-12-12
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References

  1. Hutchinson EC. Influenza virus. Trends Microbiol 2018; 26:809–810 [View Article] [PubMed]
     [Google Scholar]
  2. Medina RA, García-Sastre A. Influenza A viruses: new research developments. Nat Rev Microbiol 2011; 9:590–603 [View Article] [PubMed]
     [Google Scholar]
  3. Matsuzaki Y, Mizuta K, Sugawara K, Tsuchiya E, Muraki Y et al. Frequent reassortment among influenza C viruses. J Virol 2003; 77:871–881 [View Article] [PubMed]
     [Google Scholar]
  4. Hause BM, Ducatez M, Collin EA, Ran Z, Liu R et al. Isolation of a novel swine influenza virus from Oklahoma in 2011 which is distantly related to human influenza C viruses. PLoS Pathog 2013; 9:e1003176 [View Article] [PubMed]
     [Google Scholar]
  5. Odagiri T, Ishida H, Li J-Y, Endo M, Kobayashi T et al. Antigenic heterogeneity among phylogenetic clusters of influenza D viruses. J Vet Med Sci 2018; 80:1241–1244 [View Article] [PubMed]
     [Google Scholar]
  6. Murakami S, Sato R, Ishida H, Katayama M, Takenaka-Uema A et al. Influenza D virus of new phylogenetic lineage, Japan. Emerg Infect Dis 2020; 26:168–171 [View Article] [PubMed]
     [Google Scholar]
  7. Webster RG, Bean WJ, Gorman OT, Chambers TM, Kawaoka Y. Evolution and ecology of influenza A viruses. Microbiol Rev 1992; 56:152–179 [View Article] [PubMed]
     [Google Scholar]
  8. Yoon S-W, Webby RJ, Webster RG. Evolution and ecology of influenza A viruses. Curr Top Microbiol Immunol 2014; 385:359–375 [View Article] [PubMed]
     [Google Scholar]
  9. de Graaf M, Fouchier RAM. Role of receptor binding specificity in influenza A virus transmission and pathogenesis. Embo J 2014; 33:823–841 [View Article] [PubMed]
     [Google Scholar]
  10. Tan J, Asthagiri Arunkumar G, Krammer F. Universal influenza virus vaccines and therapeutics: where do we stand with influenza B virus?. Curr Opin Immunol 2018; 53:45–50 [View Article] [PubMed]
     [Google Scholar]
  11. Koutsakos M, Nguyen THO, Barclay WS, Kedzierska K. Knowns and unknowns of influenza B viruses. Future Microbiol 2016; 11:119–135 [View Article] [PubMed]
     [Google Scholar]
  12. Kauppila J, Rönkkö E, Juvonen R, Saukkoriipi A, Saikku P et al. Influenza C virus infection in military recruits-symptoms and clinical manifestation. J Med Virol 2014; 86:879–885 [View Article] [PubMed]
     [Google Scholar]
  13. Wang M, Veit M. Hemagglutinin-esterase-fusion (HEF) protein of influenza C virus. Protein Cell 2016; 7:28–45 [View Article] [PubMed]
     [Google Scholar]
  14. Matsuzaki Y, Sugawara K, Abiko C, Ikeda T, Aoki Y et al. Epidemiological information regarding the periodic epidemics of influenza C virus in Japan (1996-2013) and the seroprevalence of antibodies to different antigenic groups. J Clin Virol 2014; 61:87–93 [View Article] [PubMed]
     [Google Scholar]
  15. Matsuzaki Y, Abiko C, Mizuta K, Sugawara K, Takashita E et al. A nationwide epidemic of influenza C virus infection in Japan in 2004. J Clin Microbiol 2007; 45:783–788 [View Article] [PubMed]
     [Google Scholar]
  16. Hause BM, Collin EA, Liu R, Huang B, Sheng Z et al. Characterization of a novel influenza virus in cattle and swine: proposal for a new genus in the Orthomyxoviridae family. mBio 2014; 5:e00031–00014 [View Article] [PubMed]
     [Google Scholar]
  17. Su S, Fu X, Li G, Kerlin F, Veit M. Novel influenza D virus: epidemiology, pathology, evolution and biological characteristics. Virulence 2017; 8:1580–1591 [View Article] [PubMed]
     [Google Scholar]
  18. Quast M, Sreenivasan C, Sexton G, Nedland H, Singrey A et al. Serological evidence for the presence of influenza D virus in small ruminants. Vet Microbiol 2015; 180:281–285 [View Article] [PubMed]
     [Google Scholar]
  19. Nedland H, Wollman J, Sreenivasan C, Quast M, Singrey A et al. Serological evidence for the co-circulation of two lineages of influenza D viruses in equine populations of the Midwest United States. Zoonoses Public Health 2018; 65:e148–e154 [View Article] [PubMed]
     [Google Scholar]
  20. White SK, Ma W, McDaniel CJ, Gray GC, Lednicky JA. Serologic evidence of exposure to influenza D virus among persons with occupational contact with cattle. J Clin Virol 2016; 81:31–33 [View Article] [PubMed]
     [Google Scholar]
  21. Salem E, Cook EAJ, Lbacha HA, Oliva J, Awoume F et al. Serologic evidence for influenza C and D virus among ruminants and Camelids, Africa, 1991-2015. Emerg Infect Dis 2017; 23:1556–1559 [View Article] [PubMed]
     [Google Scholar]
  22. Collin EA, Sheng Z, Lang Y, Ma W, Hause BM et al. Cocirculation of two distinct genetic and antigenic lineages of proposed influenza D virus in cattle. J Virol 2015; 89:1036–1042 [View Article] [PubMed]
     [Google Scholar]
  23. Sreenivasan CC, Thomas M, Kaushik RS, Wang D, Li F. Influenza A in bovine species: a narrative literature review. Viruses 2019; 11:561 17 06 2019 [View Article] [PubMed]
     [Google Scholar]
  24. Ferguson L, Eckard L, Epperson WB, Long L-P, Smith D et al. Influenza D virus infection in Mississippi beef cattle. Virology 2015; 486:28–34 [View Article] [PubMed]
     [Google Scholar]
  25. Luo J, Ferguson L, Smith DR, Woolums AR, Epperson WB et al. Serological evidence for high prevalence of influenza D viruses in cattle, Nebraska, United States, 2003-2004. Virology 2017; 501:88–91 [View Article] [PubMed]
     [Google Scholar]
  26. Silveira S, Falkenberg SM, Kaplan BS, Crossley B, Ridpath JF et al. Serosurvey for influenza D virus exposure in cattle, United States, 2014-2015. Emerg Infect Dis 2019; 25:2074–2080 [View Article] [PubMed]
     [Google Scholar]
  27. Mitra N, Cernicchiaro N, Torres S, Li F, Hause BM. Metagenomic characterization of the virome associated with bovine respiratory disease in feedlot cattle identified novel viruses and suggests an etiologic role for influenza D virus. J Gen Virol 2016; 97:1771–1784 [View Article] [PubMed]
     [Google Scholar]
  28. Zhang M, Hill JE, Fernando C, Alexander TW, Timsit E et al. Respiratory viruses identified in Western Canadian beef cattle by metagenomic sequencing and their association with bovine respiratory disease. Transbound Emerg Dis 2019; 66:1379–1386 [View Article] [PubMed]
     [Google Scholar]
  29. Bailey ES, Fieldhouse JK, Alarja NA, Chen DD, Kovalik ME et al. First sequence of influenza D virus identified in poultry farm bioaerosols in Sarawak, Malaysia. Trop Dis Travel Med Vaccines 2020; 6:5 [View Article] [PubMed]
     [Google Scholar]
  30. Martin BE, Sun H, Carrel M, Cunningham FL, Baroch JA et al. Feral swine in the United States have been exposed to both avian and swine influenza A viruses. Appl Environ Microbiol 2017; 83: 01 10 2017 [View Article] [PubMed]
     [Google Scholar]
  31. Feng Z, Baroch JA, Long L-P, Xu Y, Cunningham FL et al. Influenza a subtype H3 viruses in feral swine, United States, 2011-2012. Emerg Infect Dis 2014; 20:839–842 [View Article] [PubMed]
     [Google Scholar]
  32. Ferguson L, Luo K, Olivier AK, Cunningham FL, Blackmon S et al. Influenza D virus infection in feral swine populations, United States. Emerg Infect Dis 2018; 24:1020–1028 [View Article] [PubMed]
     [Google Scholar]
  33. Ducatez MF, Pelletier C, Meyer G. Influenza D virus in cattle, France, 2011-2014. Emerg Infect Dis 2015; 21:368–371 [View Article] [PubMed]
     [Google Scholar]
  34. Chiapponi C, Faccini S, De Mattia A, Baioni L, Barbieri I et al. Detection of influenza D virus among swine and cattle, Italy. Emerg Infect Dis 2016; 22:352–354 [View Article] [PubMed]
     [Google Scholar]
  35. Dane H, Duffy C, Guelbenzu M, Hause B, Fee S et al. Detection of influenza D virus in bovine respiratory disease samples, UK. Transbound Emerg Dis 2019; 66:2184–2187 [View Article] [PubMed]
     [Google Scholar]
  36. Snoeck CJ, Oliva J, Pauly M, Losch S, Wildschutz F et al. Influenza D virus circulation in cattle and swine, Luxembourg, 2012-2016. Emerg Infect Dis 2018; 24:1388–1389 [View Article] [PubMed]
     [Google Scholar]
  37. Flynn O, Gallagher C, Mooney J, Irvine C, Ducatez M et al. Influenza D virus in cattle, Ireland. Emerg Infect Dis 2018; 24:389–391 [View Article] [PubMed]
     [Google Scholar]
  38. Gorin S, Fablet C, Quéguiner S, Barbier N, Paboeuf F et al. Assessment of influenza D virus in domestic pigs and wild boars in France: apparent limited spread within swine populations despite serological evidence of breeding sow exposure. Viruses 2019; 12:25 24 12 2019 [View Article] [PubMed]
     [Google Scholar]
  39. Rosignoli C, Faccini S, Merenda M, Chiapponi C, Ad M et al. Influenza D virus infection in cattle in Italy. Large Animal Review 2017; 23:123–128
     [Google Scholar]
  40. Oliva J, Eichenbaum A, Belin J, Gaudino M, Guillotin J et al. Serological evidence of influenza D virus circulation among cattle and small ruminants in France. Viruses 2019; 11:516 05 06 2019 [View Article] [PubMed]
     [Google Scholar]
  41. O'Donovan T, Donohoe L, Ducatez MF, Meyer G, Ryan E. Seroprevalence of influenza D virus in selected sample groups of Irish cattle, sheep and pigs. Ir Vet J 2019; 72:11 [View Article] [PubMed]
     [Google Scholar]
  42. Foni E, Chiapponi C, Baioni L, Zanni I, Merenda M et al. Influenza D in Italy: towards a better understanding of an emerging viral infection in swine. Sci Rep 2017; 7:11660 [View Article] [PubMed]
     [Google Scholar]
  43. Jiang W-M, Wang S-C, Peng C, Yu J-M, Zhuang Q-Y et al. Identification of a potential novel type of influenza virus in bovine in China. Virus Genes 2014; 49:493–496 [View Article] [PubMed]
     [Google Scholar]
  44. Zhai S-L, Zhang H, Chen S-N, Zhou X, Lin T et al. Influenza D virus in animal species in Guangdong Province, southern China. Emerg Infect Dis 2017; 23:1392–1396 [View Article] [PubMed]
     [Google Scholar]
  45. Asha K, Kumar B. Emerging influenza D virus threat: what we know so far!. J Clin Med 2019; 8:E192192 05 02 2019 [View Article] [PubMed]
     [Google Scholar]
  46. Murakami S, Endoh M, Kobayashi T, Takenaka-Uema A, Chambers JK et al. Influenza D virus infection in herd of cattle, Japan. Emerg Infect Dis 2016; 22:1517–1519 [View Article] [PubMed]
     [Google Scholar]
  47. Horimoto T, Hiono T, Mekata H, Odagiri T, Lei Z et al. Nationwide distribution of bovine influenza D virus infection in Japan. PLoS One 2016; 11:e0163828 [View Article] [PubMed]
     [Google Scholar]
  48. Yilmaz A, Umar S, Turan N, Aydin O, Tali HE et al. First report of influenza D virus infection in Turkish cattle with respiratory disease. Res Vet Sci 2020; 130:98–102 [View Article] [PubMed]
     [Google Scholar]
  49. Murakami S, Odagiri T, Melaku SK, Bazartseren B, Ishida H et al. Influenza D virus infection in dromedary camels, Ethiopia. Emerg Infect Dis 2019; 25:1224–1226 [View Article] [PubMed]
     [Google Scholar]
  50. Fusade-Boyer M, Pato PS, Komlan M, Dogno K, Batawui K et al. Risk mapping of influenza D virus occurrence in ruminants and swine in Togo using a spatial Multicriteria decision analysis approach. Viruses 2020; 12:128 21 01 2020 [View Article] [PubMed]
     [Google Scholar]
  51. Hongo S, Sugawara K, Muraki Y, Matsuzaki Y, Takashita E et al. Influenza C virus CM2 protein is produced from a 374-amino-acid protein (p42) by signal peptidase cleavage. J Virol 1999; 73:46–50 [View Article] [PubMed]
     [Google Scholar]
  52. Matrosovich M, Herrler G, Klenk HD. Sialic acid receptors of viruses. Top Curr Chem 2015; 367:1–28 [View Article] [PubMed]
     [Google Scholar]
  53. Varki A. Multiple changes in sialic acid biology during human evolution. Glycoconj J 2009; 26:231–245 [View Article] [PubMed]
     [Google Scholar]
  54. Varki A, Schauer R et al. Sialic Acids. In Varki A, Cummings RD, Esko JD, Freeze HH. (editors) Essentials of Glycobiology Cold Spring Harbor (NY); 2009
     [Google Scholar]
  55. Liu R, Sreenivasan C, Yu H, Sheng Z, Newkirk SJ et al. Influenza D virus diverges from its related influenza C virus in the recognition of 9-O-acetylated N-acetyl- or N-glycolyl-neuraminic acid-containing glycan receptors. Virology 2020; 545:16–23 [View Article] [PubMed]
     [Google Scholar]
  56. Wang Q, Tian X, Chen X, Ma J. Structural basis for receptor specificity of influenza B virus hemagglutinin. Proc Natl Acad Sci U S A 2007; 104:16874–16879 [View Article] [PubMed]
     [Google Scholar]
  57. Wilson IA, Skehel JJ, Wiley DC. Structure of the haemagglutinin membrane glycoprotein of influenza virus at 3 A resolution. Nature 1981; 289:366–373 [View Article] [PubMed]
     [Google Scholar]
  58. Mesecar AD, Ratia K. Viral destruction of cell surface receptors. Proc Natl Acad Sci U S A 2008; 105:8807–8808 [View Article] [PubMed]
     [Google Scholar]
  59. Song H, Qi J, Khedri Z, Diaz S, Yu H et al. An open receptor-binding cavity of Hemagglutinin-Esterase-Fusion glycoprotein from newly-identified influenza D virus: basis for its broad cell tropism. PLoS Pathog 2016; 12:e1005411 [View Article] [PubMed]
     [Google Scholar]
  60. Dubois J, Terrier O, Rosa-Calatrava M. Influenza viruses and mRNA splicing: doing more with less. mBio 2014; 5:e00070–00014 [View Article] [PubMed]
     [Google Scholar]
  61. Lamb RA, Lai CJ, Choppin PW. Sequences of mRNAs derived from genome RNA segment 7 of influenza virus: colinear and interrupted mRNAs code for overlapping proteins. Proc Natl Acad Sci U S A 1981; 78:4170–4174 [View Article] [PubMed]
     [Google Scholar]
  62. Horvath CM, Williams MA, Lamb RA. Eukaryotic coupled translation of tandem cistrons: identification of the influenza B virus BM2 polypeptide. Embo J 1990; 9:2639–2647 [View Article] [PubMed]
     [Google Scholar]
  63. Pekosz A, Lamb RA. Influenza C virus CM2 integral membrane glycoprotein is produced from a polypeptide precursor by cleavage of an internal signal sequence. Proc Natl Acad Sci U S A 1998; 95:13233–13238 [View Article] [PubMed]
     [Google Scholar]
  64. Kesinger E, Liu J, Jensen A, Chia CP, Demers A et al. Influenza D virus M2 protein exhibits ion channel activity in Xenopus laevis oocytes. PLoS One 2018; 13:e0199227 [View Article] [PubMed]
     [Google Scholar]
  65. Bogdanow B, Wang X, Eichelbaum K, Sadewasser A, Husic I et al. The dynamic proteome of influenza A virus infection identifies M segment splicing as a host range determinant. Nat Commun 2019; 10:5518 [View Article] [PubMed]
     [Google Scholar]
  66. Yu J, Hika B, Liu R, Sheng Z, Hause BM et al. The hemagglutinin-esterase fusion glycoprotein is a primary determinant of the exceptional thermal and acid stability of influenza D virus. mSphere 2017; 2: 09 08 2017 [View Article] [PubMed]
     [Google Scholar]
  67. Russell CJ, Hu M, Okda FA. Influenza hemagglutinin protein stability, activation, and pandemic risk. Trends Microbiol 2018; 26:841–853 [View Article] [PubMed]
     [Google Scholar]
  68. Bailey ES, Choi JY, Zemke J, Yondon M, Gray GC. Molecular surveillance of respiratory viruses with bioaerosol sampling in an Airport. Trop Dis Travel Med Vaccines 2018; 4:11 [View Article] [PubMed]
     [Google Scholar]
  69. Yu J, Liu R, Zhou B, Chou T-W, Ghedin E et al. Development and characterization of a Reverse-Genetics system for influenza D virus. J Virol 2019; 93: 01 11 2019 [View Article] [PubMed]
     [Google Scholar]
  70. Noda T, Sagara H, Yen A, Takada A, Kida H et al. Architecture of ribonucleoprotein complexes in influenza A virus particles. Nature 2006; 439:490–492 [View Article] [PubMed]
     [Google Scholar]
  71. Nakatsu S, Sagara H, Sakai-Tagawa Y, Sugaya N, Noda T et al. Complete and incomplete genome packaging of influenza A and B viruses. mBio 2016; 7:e01248-16 06 09 2016 [View Article] [PubMed]
     [Google Scholar]
  72. Nakatsu S, Murakami S, Shindo K, Horimoto T, Sagara H et al. Influenza C and D viruses package eight organized ribonucleoprotein complexes. J Virol 2018; 92: 15 03 2018 [View Article] [PubMed]
     [Google Scholar]
  73. Ishida H, Murakami S, Kamiki H, Matsugo H, Takenaka-Uema A et al. Establishment of a reverse genetics system for influenza D virus. J Virol 2020; 94: 04 05 2020 [View Article] [PubMed]
     [Google Scholar]
  74. Lee J, Wang L, Palinski R, Walsh T, He D et al. Comparison of pathogenicity and transmissibility of influenza B and D viruses in pigs. Viruses 2019; 11:905 [View Article]
     [Google Scholar]
  75. Ng TFF, Kondov NO, Deng X, Van Eenennaam A, Neibergs HL et al. A metagenomics and case-control study to identify viruses associated with bovine respiratory disease. J Virol 2015; 89:5340–5349 [View Article] [PubMed]
     [Google Scholar]
  76. Hause BM, Huntimer L, Falkenberg S, Henningson J, Lechtenberg K et al. An inactivated influenza D virus vaccine partially protects cattle from respiratory disease caused by homologous challenge. Vet Microbiol 2017; 199:47–53 [View Article] [PubMed]
     [Google Scholar]
  77. Ferguson L, Olivier AK, Genova S, Epperson WB, Smith DR et al. Pathogenesis of influenza D virus in cattle. J Virol 2016; 90:5636–5642 [View Article] [PubMed]
     [Google Scholar]
  78. Salem E, Hägglund S, Cassard H, Corre T, Näslund K et al. Pathogenesis, host innate immune response, and aerosol transmission of influenza D virus in cattle. J Virol 2019; 93: 01 04 2019 [View Article] [PubMed]
     [Google Scholar]
  79. Zhang X, Outlaw C, Olivier AK, Woolums A, Epperson W et al. Pathogenesis of co-infections of influenza D virus and Mannheimia haemolytica in cattle. Vet Microbiol 2019; 231:246–253 [View Article] [PubMed]
     [Google Scholar]
  80. Mosier D. Review of BRD pathogenesis: the old and the new. Anim Health Res Rev 2014; 15:166–168 [View Article] [PubMed]
     [Google Scholar]
  81. Skelton RM, Shepardson KM, Hatton A, Wilson PT, Sreenivasan C et al. Contribution of host immune responses against influenza D virus infection toward secondary bacterial infection in a mouse model. Viruses 2019; 11:994 29 10 2019 [View Article] [PubMed]
     [Google Scholar]
  82. Oliva J, Mettier J, Sedano L, Delverdier M, Bourges-Abella N et al. Murine model for the study of influenza D virus. J Virol 2020; 94:
     [Google Scholar]
  83. Sreenivasan C, Thomas M, Sheng Z, Hause BM, Collin EA et al. Replication and transmission of the novel bovine influenza D virus in a guinea pig model. J Virol 2015; 89:11990–12001 [View Article] [PubMed]
     [Google Scholar]
  84. Holwerda M, Kelly J, Laloli L, Stürmer I, Portmann J et al. Determining the replication kinetics and cellular tropism of influenza D virus on primary well-differentiated human airway epithelial cells. Viruses 2019; 11:377 24 04 2019 [View Article] [PubMed]
     [Google Scholar]
  85. Zhou J, Li C, Sachs N, Chiu MC, Wong BH-Y et al. Differentiated human airway organoids to assess infectivity of emerging influenza virus. Proc Natl Acad Sci U S A 2018; 115:6822–6827 [View Article] [PubMed]
     [Google Scholar]
  86. Kindler E, Jónsdóttir HR, Muth D, Hamming OJ, Hartmann R et al. Efficient replication of the novel human betacoronavirus EMC on primary human epithelium highlights its zoonotic potential. mBio 2013; 4:e00611–00612 [View Article] [PubMed]
     [Google Scholar]
  87. Kuiken T, Holmes EC, McCauley J, Rimmelzwaan GF, Williams CS et al. Host species barriers to influenza virus infections. Science 2006; 312:394–397 [View Article] [PubMed]
     [Google Scholar]
  88. Choi JY, Zemke J, Philo SE, Bailey ES, Yondon M et al. Aerosol sampling in a hospital emergency room setting: a complementary surveillance method for the detection of respiratory viruses. Front Public Health 2018; 6:174 [View Article] [PubMed]
     [Google Scholar]
  89. Borkenhagen LK, Mallinson KA, Tsao RW, Ha S-J, Lim W-H et al. Surveillance for respiratory and diarrheal pathogens at the human-pig interface in Sarawak, Malaysia. PLoS One 2018; 13:e0201295 [View Article] [PubMed]
     [Google Scholar]
  90. Smith DB, Gaunt ER, Digard P, Templeton K, Simmonds P. Detection of influenza C virus but not influenza D virus in Scottish respiratory samples. J Clin Virol 2016; 74:50–53 [View Article] [PubMed]
     [Google Scholar]
  91. Trombetta CM, Marchi S, Manini I, Kistner O, Li F et al. Influenza D virus: serological evidence in the Italian population from 2005 to 2017. Viruses 2019; 12:30 27 12 2019 [View Article] [PubMed]
     [Google Scholar]
  92. Lauterbach SE, Nelson SW, Robinson ME, Lorbach JN, Nolting JM et al. Assessing exhibition swine as potential disseminators of infectious disease through the detection of five respiratory pathogens at agricultural exhibitions. Vet Res 2019; 50:63 [View Article] [PubMed]
     [Google Scholar]
  93. Chiapponi C, Faccini S, Fusaro A, Moreno A, Prosperi A et al. Detection of a new genetic cluster of influenza D virus in Italian cattle. Viruses 2019; 11:1110 30 11 2019 [View Article] [PubMed]
     [Google Scholar]
  94. Mekata H, Yamamoto M, Hamabe S, Tanaka H, Omatsu T et al. Molecular epidemiological survey and phylogenetic analysis of bovine influenza D virus in Japan. Transbound Emerg Dis 2018; 65:e355–e360 [View Article] [PubMed]
     [Google Scholar]
  95. Family - Orthomyxoviridae,. Virus Taxonomy: Ninth Report of the International Committee on Taxonomy of Viruses, 2012;pp. 749-–761;ISBN: 9780123846846; http://www.sciencedirect.com/science/article/pii/B9780123846846000616. [View Article]
     [Google Scholar]
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The first decade of research advances in influenza D virus
J. Gen. Virol. 102, 001529 (2021); https://doi.org/10.1099/jgv.0.001529
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