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Journal of General Virology header logo Journal of General Virology

Volume 101, Issue 12

Predicting the recombination potential of severe acute respiratory syndrome coronavirus 2 and Middle East respiratory syndrome coronavirus Open Access

Abstract

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) recently emerged to cause widespread infections in humans. SARS-CoV-2 infections have been reported in the Kingdom of Saudi Arabia, where Middle East respiratory syndrome coronavirus (MERS-CoV) causes seasonal outbreaks with a case fatality rate of ~37 %. Here we show that there exists a theoretical possibility of future recombination events between SARS-CoV-2 and MERS-CoV RNA. Through computational analyses, we have identified homologous genomic regions within the ORF1ab and S genes that could facilitate recombination, and have analysed co-expression patterns of the cellular receptors for SARS-CoV-2 and MERS-CoV, ACE2 and DPP4, respectively, to identify human anatomical sites that could facilitate co-infection. Furthermore, we have investigated the likely susceptibility of various animal species to MERS-CoV and SARS-CoV-2 infection by comparing known virus spike protein–receptor interacting residues. In conclusion, we suggest that a recombination between SARS-CoV-2 and MERS-CoV RNA is possible and urge public health laboratories in high-risk areas to develop diagnostic capability for the detection of recombined coronaviruses in patient samples.

  • Received:
  • Accepted:
  • Published Online:
Keyword(s): coronavirus , emergence , MERS-CoV , predictions , recombination and SARS-CoV-2
Funding
This study was supported by the:
  • Canadian Institutes for Health Research
    • Principal Award Recipient: Karen Mossman
  • Natural Sciences and Engineering Research Council
    • Principal Award Recipient: Karen Mossman
© 2020 The Authors
  • This is an open-access article distributed under the terms of the Creative Commons Attribution License. The Microbiology Society waived the open access fees for this article.
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2020-09-09
2025-12-06

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Predicting the recombination potential of severe acute respiratory syndrome coronavirus 2 and Middle East respiratory syndrome coronavirus
J. Gen. Virol. 101, 1251 (2020); https://doi.org/10.1099/jgv.0.001491
/content/journal/jgv/10.1099/jgv.0.001491
/content/journal/jgv/10.1099/jgv.0.001491
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