RT Journal Article SR Electronic(1) A1 Dowall, Stuart D. A1 Graham, Victoria A. A1 Aram, Marilyn A1 Findlay-Wilson, Stephen A1 Salguero, Francisco J. A1 Emery, Kirsty A1 Hewson, RogerYR 2020 T1 Hantavirus infection in type I interferon receptor-deficient (A129) mice JF Journal of General Virology, VO 101 IS 10 SP 1047 OP 1055 DO https://doi.org/10.1099/jgv.0.001470 PB Microbiology Society, SN 1465-2099, AB Type I interferon receptor knockout mice (strain A129) were assessed as a disease model of hantavirus infection. A range of infection routes (intramuscular, intraperitoneal and intranasal) were assessed using minimally passaged Seoul virus (strain Humber). Dissemination of virus to the spleen, kidney and lung was observed at 5 days after intramuscular and intraperitoneal challenge, which was resolved by day 14. In contrast, intranasal challenge of A129 mice demonstrated virus tropism to the lung, which was maintained to day 14 post-challenge. These data support the use of the A129 mouse model for future infection studies and the in vivo evaluation of interventions., UL https://www.microbiologyresearch.org/content/journal/jgv/10.1099/jgv.0.001470