1887

Abstract

is an often overlooked and understudied emerging pathogen inhabiting many areas of the human body. Through our sequencing of strains isolated from the female bladder microbiota, we detected numerous prophage sequences. Bioinformatic analysis of these sequences identified 17 distinct groups of prophages. The majority of these phages exhibit no sequence homology to previously characterized temperate or virulent phage sequences, indicating an unexplored diversity of phages. By culturing these bacterial isolates, we confirmed that the prophages of five of these groups are capable of induction. One of these putative phages was imaged, the first such evidence of an . virus-like particle; it exhibits morphological characteristics of siphoviruses.

Funding
This study was supported by the:
  • Alan J. Wolfe , National Institutes of Health , (Award R01 DK104718)
  • Catherine Putonti , Kimberly-Clark Corporation , (Award Investigator Initiated grant)
  • Alan J. Wolfe , Kimberly-Clark Corporation , (Award Investigator Initiated grant)
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/content/journal/jgv/10.1099/jgv.0.001407
2020-04-21
2020-06-04
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