1887

Journal of General Virology header logo

Volume 99, Issue 9

Confirmation of Zika virus infection through hospital-based sentinel surveillance of acute febrile illness in Uganda,  2014–2017 Free

Abstract

Zika virus (ZIKV), transmitted by Aedes species mosquitoes, was first isolated in Uganda in 1947. From February 2014 to October 2017, the Uganda Virus Research Institute, in collaboration with the US Centers for Diseases Control and Prevention, conducted arbovirus surveillance in acute febrile illness (AFI) patients at St Francis hospital in Nkonkonjeru. Three hundred and eighty-four serum samples were collected and tested for IgM antibodies to yellow fever virus (YFV), West Nile virus (WNV), dengue virus (DENV), chikungunya virus (CHIKV) and ZIKV. Of the 384 samples, 5 were positive for ZIKV IgM. Of these five, three were confirmed by plaque reduction neutralization test (PRNT) to be ZIKV infections. Of the remaining two, one was determined to be a non-specific flavivirus infection and one was confirmed to be alphavirus-positive by reverse transcriptase polymerase chain reaction (RT-PCR). This study provides the first evidence of laboratory-confirmed ZIKV infection in Uganda in five decades, and emphasizes the need to enhance sentinel surveillance.

  • Received:
  • Accepted:
  • Published Online:
Keyword(s): Arbovirus , confirmation , hospital-based , plaque reduction neutralization test , sentinel surveillance and Zika virus
© 2018 The Authors
Loading

Article metrics loading...

/content/journal/jgv/10.1099/jgv.0.001113
2018-07-05
2024-04-20
Loading full text...

Full text loading...

/deliver/fulltext/jgv/99/9/1248.html?itemId=/content/journal/jgv/10.1099/jgv.0.001113&mimeType=html&fmt=ahah

References

  1. Chouin-Carneiro T, Vega-Rua A, Vazeille M, Yebakima A, Girod R et al. Differential susceptibilities of Aedes aegypti and Aedes albopictus from the Americas to Zika virus. PLoS Negl Trop Dis 2016; 10:e0004543 [View Article][PubMed]
     [Google Scholar]
  2. Dick GW, Kitchen SF, Haddow AJ. Zika virus (I). Isolations and serological specificity. Trans R Soc Trop Med Hyg 1952; 46:509–520 [View Article][PubMed]
     [Google Scholar]
  3. MacNamara FN. Zika virus: a report on three cases of human infection during an epidemic of jaundice in Nigeria. Trans R Soc Trop Med Hyg 1954; 48:139–145 [View Article][PubMed]
     [Google Scholar]
  4. Bearcroft WG. Zika virus infection experimentally induced in a human volunteer. Trans R Soc Trop Med Hyg 1956; 50:438–441 [View Article][PubMed]
     [Google Scholar]
  5. Simpson DI. Zika virus infection in man. Trans R Soc Trop Med Hyg 1964; 58:339–348 [View Article][PubMed]
     [Google Scholar]
  6. Moore DL, Causey OR, Carey DE, Reddy S, Cooke AR et al. Arthropod-borne viral infections of man in Nigeria, 1964–1970. Ann Trop Med Parasitol 1975; 69:49–64 [View Article][PubMed]
     [Google Scholar]
  7. Fagbami AH. Zika virus infections in Nigeria: virological and seroepidemiological investigations in Oyo State. J Hyg (Lond) 1979; 83:213–219 [View Article][PubMed]
     [Google Scholar]
  8. Filipe AR, Martins CM, Rocha H. Laboratory infection with Zika virus after vaccination against yellow fever. Arch Gesamte Virusforsch 1973; 43:315–319 [View Article][PubMed]
     [Google Scholar]
  9. Olson JG, Ksiazek TG, Suhandiman, Triwibowo. Zika virus, a cause of fever in Central Java, Indonesia. Trans R Soc Trop Med Hyg 1981; 75:389–393 [View Article]
     [Google Scholar]
  10. Duffy MR, Chen TH, Hancock WT, Powers AM, Kool JL et al. Zika virus outbreak on Yap Island, Federated States of Micronesia. N Engl J Med 2009; 360:2536–2543 [View Article][PubMed]
     [Google Scholar]
  11. ProMED-mail 2015; Undiagnosed illness - Brazil (02): Zika virus conf. ProMED-mail 2015. 20150515.3364149 www.promedmail.org
  12. Faria NR, Azevedo R, Kraemer MUG, Souza R, Cunha MS et al. Zika virus in the Americas: early epidemiological and genetic findings. Science 2016; 352:345–349 [View Article][PubMed]
     [Google Scholar]
  13. Brasil P, Pereira JP, Moreira ME, Ribeiro Nogueira RM, Damasceno L et al. Zika virus infection in pregnant women in Rio de Janeiro. N Engl J Med 2016; 375:2321–2334 [View Article]
     [Google Scholar]
  14. Mlakar J, Korva M, Tul N, Popović M, Poljšak-Prijatelj M et al. Zika virus associated with microcephaly. N Engl J Med 2016; 374:951–958 [View Article][PubMed]
     [Google Scholar]
  15. Broutet N, Krauer F, Riesen M, Khalakdina A, Almiron M et al. Zika virus as a cause of neurologic disorders. N Engl J Med 2016; 374:1506–1509 [View Article][PubMed]
     [Google Scholar]
  16. Carteaux G, Maquart M, Bedet A, Contou D, Brugières P et al. Zika virus associated with meningoencephalitis. N Engl J Med 2016; 374:1595–1596 [View Article][PubMed]
     [Google Scholar]
  17. Mead PS, Hills SL, Brooks JT. Zika virus as a sexually transmitted pathogen. Curr Opin Infect Dis 2018; 31:39–44 [View Article][PubMed]
     [Google Scholar]
  18. World Health Organization 2016 Zika Virus and Potential Complications Geneva: WHO; www.who.int/emergencies/zika-virus/en/
     [Google Scholar]
  19. Jones KE, Patel NG, Levy MA, Storeygard A, Balk D et al. Global trends in emerging infectious diseases. Nature 2008; 451:990–993 [View Article][PubMed]
     [Google Scholar]
  20. Nyakarahuka L, Ayebare S, Mosomtai G, Kankya C, Lutwama J et al. Ecological niche modeling for filoviruses: a risk map for Ebola and Marburg virus disease outbreaks in Uganda. PLoS Curr 2017; 9: [View Article][PubMed]
     [Google Scholar]
  21. Mayanja M, Mutebi JP, Crabtree MB, Ssenfuka F, Muwawu T et al. Studies on the species composition and relative abundance of mosquitoes of Mpigi District, central Uganda. J Entomol Zool Stud 2014; 2:317–322[PubMed]
     [Google Scholar]
  22. Mutebi JP, Crabtree MB, Kading RC, Powers AM, Lutwama JJ et al. Mosquitoes of western Uganda. J Med Entomol 2012; 49:1289–1306 [View Article][PubMed]
     [Google Scholar]
  23. Mutebi JP, Crabtree MB, Kading RC, Powers AM, Ledermann JP et al. Mosquitoes of Northwestern Uganda. J Med Entomol 2018; 55:587–599 [View Article][PubMed]
     [Google Scholar]
  24. Martin DA, Muth DA, Brown T, Johnson AJ, Karabatsos N et al. Standardization of immunoglobulin M capture enzyme-linked immunosorbent assays for routine diagnosis of arboviral infections. J Clin Microbiol 2000; 38:1823–1826[PubMed]
     [Google Scholar]
  25. Beaty BJ, Calisher CH, Shope RE. Arboviruses. In Schmidt NJ, Lennette DA, Lennette ET, Lennette EH, Emmons RW et al. (editors) Diagnostic Procedures for Viral, Rickettsial and Chlamydial Infections, 7th ed. Washington, DC: American Public Health Association; 1995 pp. 204–205
     [Google Scholar]
  26. Ledermann JP, Zeidner N, Borland EM, Mutebi JP, Lanciotti RS et al. Sunguru virus: a novel virus in the family Rhabdoviridae isolated from a chicken in north-western Uganda. J Gen Virol 2014; 95:1436–1443 [View Article][PubMed]
     [Google Scholar]
  27. Mossel EC, Crabtree MB, Mutebi JP, Lutwama JJ, Borland EM et al. Arboviruses isolated from mosquitoes collected in Uganda, 2008-2012. J Med Entomol 2017; 54:1403–1409 [View Article][PubMed]
     [Google Scholar]
  28. Lanciotti RS, Kosoy OL, Laven JJ, Velez JO, Lambert AJ et al. Genetic and serologic properties of Zika virus associated with an epidemic, Yap State, Micronesia, 2007. Emerg Infect Dis 2008; 14:1232–1239 [View Article][PubMed]
     [Google Scholar]
  29. Rabe IB, Staples JE, Villanueva J, Hummel KB, Johnson JA et al. Interim guidance for interpretation of zika virus antibody test results. MMWR Morb Mortal Wkly Rep 2016; 65:543–546 [View Article][PubMed]
     [Google Scholar]
http://instance.metastore.ingenta.com/content/journal/jgv/10.1099/jgv.0.001113
Loading
Confirmation of Zika virus infection through hospital-based sentinel surveillance of acute febrile illness in Uganda,  2014–2017
J. Gen. Virol. 99, 1248 (2018); https://doi.org/10.1099/jgv.0.001113
/content/journal/jgv/10.1099/jgv.0.001113
/content/journal/jgv/10.1099/jgv.0.001113
Loading

Data & Media loading...

Supplements

Supplementary File 1

PDF

Most cited Most Cited RSS feed

This is a required field
Please enter a valid email address
Approval was a Success
Invalid data
An Error Occurred
Approval was partially successful, following selected items could not be processed due to error