1887

Journal of General Virology header logo

Volume 99, Issue 8

Long-term stability of antibody responses elicited by Dengue virus envelope DIII-based DNA vaccines Free

Abstract

Dengue virus (DENV) is one the most important viral pathogens worldwide. Currently there is an imperative need for a reliable vaccine capable of inducing durable protection against all four serotypes. We have previously reported strongly neutralizing and highly specific antibody responses from all four serotypes to a DNA vaccine based on an engineered version of DENV E protein’s domain III (DIII). Here, we show that monovalent and tetravalent immunizations with the DIII-based DNA vaccines are also capable of inducing highly stable antibody responses that remain strongly neutralizing over long periods of time. Our results demonstrate that DNA-vaccinated mice maintain a strong antibody response in terms of titre, avidity and virus-neutralizing capability 1 year after immunization.

  • Received:
  • Accepted:
  • Published Online:
Keyword(s): Dengue , Dengue virus , DNA vaccine , envelope protein , flaviviruses and genetic vaccines
© 2018 The Authors
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2018-06-20
2024-04-25
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Long-term stability of antibody responses elicited by Dengue virus envelope DIII-based DNA vaccines
J. Gen. Virol. 99, 1078 (2018); https://doi.org/10.1099/jgv.0.001094
/content/journal/jgv/10.1099/jgv.0.001094
/content/journal/jgv/10.1099/jgv.0.001094
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