1887

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Volume 98, Issue 7

Induction of interferon and interferon-induced antiviral effector genes following a primary bovine herpesvirus-1 (BHV-1) respiratory infection Free

Abstract

investigations have identified a variety of mechanisms by which herpesviruses evade interferon-stimulated antiviral effector mechanisms. However, these immune evasion mechanisms have not been evaluated during a bovine herpesvirus-1 (BHV-1) infection. This study investigated the transcription and secretion of type I and II interferons (IFNs) and the transcription of IFN-stimulated genes (ISGs) during a primary BHV-1 infection of the upper respiratory tract (URT) in naïve calves. IFN-α, -β and -γ transcription in nasal turbinates and protein levels in nasal secretions increased following infection. Increased IFN type I and II secretion was detected 3 days post-infection (p.i.) and IFN production increased in parallel with virus shedding. Expression of ISGs, including , and also increased significantly (<0.05) in nasal turbinates on day 3 p.i. and elevated ISG expression persisted throughout the period of viral shedding. In contrast, RNAase L gene expression was not induced during the BHV-1 infection in the nasal turbinates, but was induced on day 10 p.i. in the trachea. studies confirmed that recombinant bovine (rBo)IFN-α, -β and -γ induced expression of , and , but decreased transcript in bovine epithelial cells. Relative to vesicular stomatitisvirus (VSV), BHV-1 was resistant to the antiviral activity of rBoIFN-α and –γ, but treatment of epithelial cells with 10 ng rBoIFN-β ml effected an 80 % inhibition of BHV-1 replication and complete inhibition of VSV replication. These observations confirm that the transcription and translation of type I and II IFNs increase during BHV-1 infection, while the transcription of some ISGs is not inhibited.

  • Received:
  • Accepted:
  • Published Online:
Keyword(s): BHV-1 , interferon-induced antiviral effector genes and respiratory infection
© 2017 The Authors
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2017-07-01
2024-04-18
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Induction of interferon and interferon-induced antiviral effector genes following a primary bovine herpesvirus-1 (BHV-1) respiratory infection
J. Gen. Virol. 98, 1831 (2017); https://doi.org/10.1099/jgv.0.000825
/content/journal/jgv/10.1099/jgv.0.000825
/content/journal/jgv/10.1099/jgv.0.000825
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