1887

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Volume 98, Issue 6

Cross-species antiviral activity of goose interferon lambda against duck plague virus is related to its positive self-regulatory feedback loop Free

Abstract

Duck plague virus (DPV) is a virus of the family that leads to acute disease with a high mortality rate in ducks. Control of the disease contributes to the development of poultry breeding. Type III IFN family (IFN-λs) is a novel member of the IFN family, and goose IFN-λ (goIFN-λ) is a newly identified gene whose antiviral function has only been investigated to a limited extent. Here, the cross-species antiviral activity of goIFN-λ against DPV in duck embryo fibroblasts (DEFs) was studied. We found that pre-treatment with goIFN-λ greatly increased the expression of IFN-λ in both heterologous DEFs and homologous goose embryo fibroblasts (GEFs), while differentially inducing IFNα- and IFN-stimulated genes. Additionally, a positive self-regulatory feedback loop of goIFN-λ was blocked by a mouse anti-goIFN-λ polyclonal antibody, which was confirmed in both homologous GEFs and goose peripheral blood mononuclear cells (PBMCs). The suppression of the BAC-DPV-EGFP by goIFN-λ in DEFs was confirmed by fluorescence microscopy, flow cytometry (FCM) analysis, viral copies and titre detection, which can be rescued by mouse anti-goIFN-λ polyclonal antibody incubation. Finally, reporter gene assays indicated that the cross-species antiviral activity of goIFN-λ against BAC-DPV-EGFP is related to its positive self-regulatory feedback loop and subsequent ISG induction. Our data shed light on the fundamental mechanisms of goIFN-λ antiviral function and extend the considerable range of therapeutic applications in multiple-poultry disease

  • Received:
  • Accepted:
  • Published Online:
Keyword(s): a positive self-regulatory feedback loop , BAC-DPV-EGFP virus , cross-species antiviral activity and goose interferon-λ
© 2017 The Authors
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2017-06-01
2024-04-24
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Cross-species antiviral activity of goose interferon lambda against duck plague virus is related to its positive self-regulatory feedback loop
J. Gen. Virol. 98, 1455 (2017); https://doi.org/10.1099/jgv.0.000788
/content/journal/jgv/10.1099/jgv.0.000788
/content/journal/jgv/10.1099/jgv.0.000788
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