1887

Abstract

In Egypt, zoonotic A/goose/Guangdong/1/96 (gs/GD-like) highly pathogenic avian influenza virus (HPAIV) H5N1 of clade 2.2.1.2 is entrenched in poultry populations and has co-circulated with low-pathogenic avian influenza virus H9N2 of the G1 lineage since 2010. Here, the impact of H9N2 infection or vaccination on the course of consecutive infection with a lethal Egyptian HPAIV H5N1 is studied. Three-week-old chickens were infected with H9N2 or vaccinated with inactivated H9N2 or H5N1 antigens and challenged three weeks later by an HPAIV H5N1. Interestingly, pre-infection of chickens with H9N2 decreased the oral excretion of H5N1 to levels that were comparable to those of H5N1-immunized chickens, but vaccination with inactivated H9N2 did not. H9N2 pre-infection modulated but did not conceal clinical disease by HPAIV H5N1. By contrast, homologous H5 vaccination abolished clinical syndromic surveillance, although vaccinated clinical healthy birds were capable of spreading the virus.

Loading

Article metrics loading...

/content/journal/jgv/10.1099/jgv.0.000767
2017-06-01
2019-12-14
Loading full text...

Full text loading...

/deliver/fulltext/jgv/98/6/1169.html?itemId=/content/journal/jgv/10.1099/jgv.0.000767&mimeType=html&fmt=ahah

References

  1. King AM, Lefkowitz E, Adams MJ, Carsten EB. (editors) Ninth Report of the International Committee on Taxonomy of Viruses London, UK: Elsevier/Academic Press; 2011
    [Google Scholar]
  2. Thomas JK, Noppenberger J. Avian influenza: a review. Am J Health Syst Pharm 2007;64:149–165 [CrossRef][PubMed]
    [Google Scholar]
  3. Mehle A. Unusual influenza A viruses in bats. Viruses 2014;6:3438–3449 [CrossRef][PubMed]
    [Google Scholar]
  4. Harder TC, Siebert U, Wohlsein P, Vahlenkamp T. Influenza A virus infections in marine mammals and terrestrial carnivores. Berl Munch Tierarztl Wochenschr 2013;126:500–508[PubMed]
    [Google Scholar]
  5. Imai M, Herfst S, Sorrell EM, Schrauwen EJ, Linster M et al. Transmission of influenza A/H5N1 viruses in mammals. Virus Res 2013;178:15–20 [CrossRef][PubMed]
    [Google Scholar]
  6. Kalthoff D, Globig A, Beer M. (Highly pathogenic) avian influenza as a zoonotic agent. Vet Microbiol 2010;140:237–245 [CrossRef][PubMed]
    [Google Scholar]
  7. Swayne DE, Suarez DL, Sims LD. Influenza. In: Diseases of Poultry, 13th ed. Willey-Blackwell; 2013; pp.181–218[CrossRef]
    [Google Scholar]
  8. Kuiken T. Is low pathogenic avian influenza virus virulent for wild waterbirds?. Proc Biol Sci 2013;280:20130990 [CrossRef][PubMed]
    [Google Scholar]
  9. Halvorson DA. Control of low pathogenicity avian influenza. In Swayne DE. (editor) Avian Influenza Ames, IO: Blackwell Publishing; 2008; pp.513–536[CrossRef]
    [Google Scholar]
  10. Bui C, Bethmont A, Chughtai AA, Gardner L, Sarkar S et al. A systematic review of the comparative epidemiology of avian and human influenza A H5N1 and H7N9 - lessons and unanswered questions. Transbound Emerg Dis 2016;63:602–620 [CrossRef][PubMed]
    [Google Scholar]
  11. Guan Y, Smith GJ, Webby R, Webster RG. Molecular epidemiology of H5N1 avian influenza. Rev Sci Tech 2009;28:39–47 [CrossRef][PubMed]
    [Google Scholar]
  12. Peiris JS, De Jong MD, Guan Y. Avian influenza virus (H5N1): a threat to human health. Clin Microbiol Rev 2007;20:243–267 [CrossRef][PubMed]
    [Google Scholar]
  13. Aamir UB, Wernery U, Ilyushina N, Webster RG. Characterization of avian H9N2 influenza viruses from United Arab Emirates 2000 to 2003. Virology 2007;361:45–55 [CrossRef][PubMed]
    [Google Scholar]
  14. Gerloff NA, Khan SU, Balish A, Shanta IS, Simpson N et al. Multiple reassortment events among highly pathogenic avian influenza A(H5N1) viruses detected in Bangladesh. Virology 2014;450-451:297–307 [CrossRef][PubMed]
    [Google Scholar]
  15. Guan Y, Shortridge KF, Krauss S, Webster RG. Molecular characterization of H9N2 influenza viruses: were they the donors of the "internal" genes of H5N1 viruses in Hong Kong?. Proc Natl Acad Sci USA 1999;96:9363–9367 [CrossRef][PubMed]
    [Google Scholar]
  16. Arafa AS, Hagag NM, Yehia N, Zanaty AM, Naguib MM et al. Effect of cocirculation of highly pathogenic avian influenza H5N1 subtype with low pathogenic H9N2 subtype on the spread of infections. Avian Dis 2012;56:849–857 [CrossRef][PubMed]
    [Google Scholar]
  17. Marinova-Petkova A, Shanmuganatham K, Feeroz MM, Jones-Engel L, Hasan MK et al. The continuing evolution of H5N1 and H9N2 influenza viruses in Bangladesh between 2013 and 2014. Avian Dis 2016;60:108–117 [CrossRef][PubMed]
    [Google Scholar]
  18. Jones YL, Swayne DE. Comparative pathobiology of low and high pathogenicity H7N3 Chilean avian influenza viruses in chickens. Avian Dis 2004;48:119–128 [CrossRef][PubMed]
    [Google Scholar]
  19. Khalenkov A, Perk S, Panshin A, Golender N, Webster RG. Modulation of the severity of highly pathogenic H5N1 influenza in chickens previously inoculated with Israeli H9N2 influenza viruses. Virology 2009;383:32–38 [CrossRef][PubMed]
    [Google Scholar]
  20. Seo SH, Webster RG. Cross-reactive, cell-mediated immunity and protection of chickens from lethal H5N1 influenza virus infection in Hong Kong poultry markets. J Virol 2001;75:2516–2525 [CrossRef][PubMed]
    [Google Scholar]
  21. Monne I, Hussein HA, Fusaro A, Valastro V, Hamoud MM et al. H9N2 influenza A virus circulates in H5N1 endemically infected poultry population in Egypt. Influenza Other Respir Viruses 2013;7:240–243 [CrossRef][PubMed]
    [Google Scholar]
  22. Young SG, Carrel M, Malanson GP, Ali MA, Kayali G. Predicting avian influenza co-infection with H5N1 and H9N2 in Northern Egypt. Int J Environ Res Public Health 2016;13:886 [CrossRef]
    [Google Scholar]
  23. Abdelwhab EM, Hassan MK, Abdel-Moneim AS, Naguib MM, Mostafa A et al. Introduction and enzootic of A/H5N1 in Egypt: virus evolution, pathogenicity and vaccine efficacy ten years on. Infect Genet Evol 2016;40:80–90 [CrossRef][PubMed]
    [Google Scholar]
  24. World Organization For Animal Health (OIE) Highly pathogenic avian influenza, chapter 2.1.14. In Manual of Diagnostic Tests and Vaccines for Terrestrial Animals OIE; 2015
    [Google Scholar]
  25. Hoffmann B, Harder T, Lange E, Kalthoff D, Reimann I et al. New real-time reverse transcriptase polymerase chain reactions facilitate detection and differentiation of novel A/H1N1 influenza virus in porcine and human samples. Berl Munch Tierarztl Wochenschr 2010;123:286–292[PubMed]
    [Google Scholar]
http://instance.metastore.ingenta.com/content/journal/jgv/10.1099/jgv.0.000767
Loading
/content/journal/jgv/10.1099/jgv.0.000767
Loading

Data & Media loading...

Most Cited This Month

This is a required field
Please enter a valid email address
Approval was a Success
Invalid data
An Error Occurred
Approval was partially successful, following selected items could not be processed due to error