1887

Abstract

Subclinical oral human papillomavirus (HPV) infection that persists for decades is likely to precede an HPV-driven squamous cell carcinoma of the head and neck, but little is known about the natural history of oral HPV. We systematically reviewed and abstracted data from nine manuscripts that examined human immunodeficiency virus-negative and cancer-free subjects for oral HPV DNA to determine the pooled baseline prevalence and incidence of newly acquired oral HPV infections, and specifically for HPV-16. We also documented the clearance rate and the median time to clearance, where data existed. Of 3762 individuals, 7.5 % had an oral infection with any HPV type (1.6 % for HPV-16). Meta-regression analysis estimated the 12-month cumulative incidence to be 4.8 % (95 % confidence interval 3.2–7.3 %). The overall oral HPV clearance was reported to be 0–80 % between studies, and the median time to clearance from 6.5 to 18 months. Oral HPV-16 clearance was 43–83 %, and median time to clearance for HPV-16 was 7–22 months. Oral HPV prevalence, incidence and clearance vary considerably between published studies from different geographical regions. Further research is required to identify predictors of persistent oral HPV infection. Measurable baseline prevalence was observed in all studies, as well as non-trivial incidence of newly acquired oral HPV infections and incomplete clearance.

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2017-04-01
2024-03-28
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References

  1. Walboomers JM, Jacobs MV, Manos MM, Bosch FX, Kummer JA et al. Human papillomavirus is a necessary cause of invasive cervical cancer worldwide. J Pathol 1999; 189:12–19 [View Article][PubMed]
    [Google Scholar]
  2. Zur Hausen H. Papillomaviruses and cancer: from basic studies to clinical application. Nat Rev Cancer 2002; 2:342–350 [View Article][PubMed]
    [Google Scholar]
  3. Gillison ML, Koch WM, Capone RB, Spafford M, Westra WH et al. Evidence for a causal association between human papillomavirus and a subset of head and neck cancers. J Natl Cancer Inst 2000; 92:709–720 [View Article][PubMed]
    [Google Scholar]
  4. Mork J, Lie AK, Glattre E, Hallmans G, Jellum E et al. Human papillomavirus infection as a risk factor for squamous-cell carcinoma of the head and neck. N Engl J Med 2001; 344:1125–1131 [View Article][PubMed]
    [Google Scholar]
  5. Ferlay J, Shin HR, Bray F, Forman D, Mathers C et al. Estimates of worldwide burden of cancer in 2008: GLOBOCAN 2008. Int J Cancer 2010; 127:2893–2917 [View Article][PubMed]
    [Google Scholar]
  6. D'Souza G, Kreimer AR, Viscidi R, Pawlita M, Fakhry C et al. Case-control study of human papillomavirus and oropharyngeal cancer. N Engl J Med 2007; 356:1944–1956 [View Article][PubMed]
    [Google Scholar]
  7. Hocking JS, Stein A, Conway EL, Regan D, Grulich A et al. Head and neck cancer in Australia between 1982 and 2005 show increasing incidence of potentially HPV-associated oropharyngeal cancers. Br J Cancer 2011; 104:886–891 [View Article][PubMed]
    [Google Scholar]
  8. Näsman A, Attner P, Hammarstedt L, Du J, Eriksson M et al. Incidence of human papillomavirus (HPV) positive tonsillar carcinoma in Stockholm, Sweden: an epidemic of viral-induced carcinoma?. Int J Cancer 2009; 125:362–366 [View Article][PubMed]
    [Google Scholar]
  9. Gillison ML, D'Souza G, Westra W, Sugar E, Xiao W et al. Distinct risk factor profiles for human papillomavirus type 16-positive and human papillomavirus type 16-negative head and neck cancers. J Natl Cancer Inst 2008; 100:407–420 [View Article][PubMed]
    [Google Scholar]
  10. Beachler DC, Sugar EA, Margolick JB, Weber KM, Strickler HD et al. Risk factors for acquisition and clearance of oral human papillomavirus infection among HIV-infected and HIV-uninfected adults. Am J Epidemiol 2015; 181:40–53 [View Article][PubMed]
    [Google Scholar]
  11. Kero K, Rautava J, Syrjänen K, Willberg J, Grenman S et al. Smoking increases oral HPV persistence among men: 7-year follow-up study. Eur J Clin Microbiol Infect Dis 2014; 33:123–133 [View Article][PubMed]
    [Google Scholar]
  12. Kreimer AR, Pierce Campbell CM, Lin HY, Fulp W, Papenfuss MR et al. Incidence and clearance of oral human papillomavirus infection in men: the HIM cohort study. Lancet 2013; 382:877–887 [View Article][PubMed]
    [Google Scholar]
  13. Louvanto K, Rautava J, Willberg J, Wideman L, Syrjänen K et al. Genotype-specific incidence and clearance of human papillomavirus in oral mucosa of women: a six-year follow-up study. PLoS One 2013; 8:e53413 [View Article][PubMed]
    [Google Scholar]
  14. Pierce Campbell CM, Kreimer AR, Lin HY, Fulp W, O'Keefe MT et al. Long-term persistence of oral human papillomavirus type 16: the HPV Infection in Men (HIM) study. Cancer Prev Res 2015; 8:190–196 [View Article][PubMed]
    [Google Scholar]
  15. Rautava J, Willberg J, Louvanto K, Wideman L, Syrjänen K et al. Prevalence, genotype distribution and persistence of human papillomavirus in oral mucosa of women: a six-year follow-up study. PLoS One 2012; 7:e42171 [View Article][PubMed]
    [Google Scholar]
  16. Rintala M, Grénman S, Puranen M, Syrjänen S. Natural history of oral papillomavirus infections in spouses: a prospective Finnish HPV family study. J Clin Virol 2006; 35:89–94 [View Article][PubMed]
    [Google Scholar]
  17. Smith EM, Ritchie JM, Summersgill KF, Hoffman HT, Wang DH et al. Human papillomavirus in oral exfoliated cells and risk of head and neck cancer. J Natl Cancer Inst 2004; 96:449–455 [View Article][PubMed]
    [Google Scholar]
  18. Pickard RK, Xiao W, Broutian TR, He X, Gillison ML. The prevalence and incidence of oral human papillomavirus infection among young men and women, aged 18–30 years. Sex Transm Dis 2012; 39:559–566 [View Article][PubMed]
    [Google Scholar]
  19. Edelstein ZR, Schwartz SM, Hawes S, Hughes JP, Feng Q et al. Rates and determinants of oral human papillomavirus infection in young men. Sex Transm Dis 2012; 39:860–867 [View Article][PubMed]
    [Google Scholar]
  20. Hong AM, Grulich AE, Jones D, Lee CS, Garland SM et al. Squamous cell carcinoma of the oropharynx in Australian males induced by human papillomavirus vaccine targets. Vaccine 2010; 28:3269–3272 [View Article][PubMed]
    [Google Scholar]
  21. King EM, Oomeer S, Gilson R, Copas A, Beddows S et al. Oral human papillomavirus infection in men who have sex with men: a systematic review and meta-analysis. PLoS One 2016; 11:e0157976 [View Article][PubMed]
    [Google Scholar]
  22. Gillison ML, Broutian T, Pickard RK, Tong ZY, Xiao W et al. Prevalence of oral HPV infection in the United States, 2009–2010. JAMA 2012; 307:693–703 [View Article][PubMed]
    [Google Scholar]
  23. Kreimer AR, Villa A, Nyitray AG, Abrahamsen M, Papenfuss M et al. The epidemiology of oral HPV infection among a multinational sample of healthy men. Cancer Epidemiol Biomarkers Prev 2011; 20:172–182 [View Article][PubMed]
    [Google Scholar]
  24. Smith EM, Swarnavel S, Ritchie JM, Wang D, Haugen TH et al. Prevalence of human papillomavirus in the oral cavity/oropharynx in a large population of children and adolescents. Pediatr Infect Dis J 2007; 26:836–840 [View Article][PubMed]
    [Google Scholar]
  25. Antonsson A, Cornford M, Perry S, Davis M, Dunne MP et al. Prevalence and risk factors for oral HPV infection in young Australians. PLoS One 2014; 9:e91761 [View Article][PubMed]
    [Google Scholar]
  26. Esquenazi D, Bussoloti Filho I, Carvalho Mda G, Barros FS. The frequency of human papillomavirus findings in normal oral mucosa of healthy people by PCR. Braz J Otorhinolaryngol 2010; 76:78–84[PubMed] [Crossref]
    [Google Scholar]
  27. Hansson BG, Rosenquist K, Antonsson A, Wennerberg J, Schildt EB et al. Strong association between infection with human papillomavirus and oral and oropharyngeal squamous cell carcinoma: a population-based case-control study in southern Sweden. Acta Otolaryngol 2005; 125:1337–1344 [View Article][PubMed]
    [Google Scholar]
  28. D'Souza G, Sugar E, Ruby W, Gravitt P, Gillison M. Analysis of the effect of DNA purification on detection of human papillomavirus in oral rinse samples by PCR. J Clin Microbiol 2005; 43:5526–5535 [View Article][PubMed]
    [Google Scholar]
  29. Clifford GM, Vaccarella S, Franceschi S, Tenet V, Umulisa MC et al. Comparison of two widely-used HPV detection and genotyping methods: GP5+/6+ PCR followed by reverse line blot hybridization and multiplex type-specific E7 PCR. J Clin Microbiol 2016; 54:2031–2038 [View Article][PubMed]
    [Google Scholar]
  30. Fuessel Haws AL, He Q, Rady PL, Zhang L, Grady J et al. Nested PCR with the PGMY09/11 and GP5+/6+ primer sets improves detection of HPV DNA in cervical samples. J Virol Methods 2004; 122:87–93 [View Article][PubMed]
    [Google Scholar]
  31. Fakhry C, Rosenthal BT, Clark DP, Gillison ML. Associations between oral HPV16 infection and cytopathology: evaluation of an oropharyngeal "pap-test equivalent" in high-risk populations. Cancer Prev Res 2011; 4:1378–1384 [View Article][PubMed]
    [Google Scholar]
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